Results 121 to 130 of about 17,522 (280)

The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway

Experimental and Molecular Medicine, 2020
Osteoclasts (OCs), cells specialized for bone resorption, are generated from monocyte/macrophage precursors by a differentiation process governed by RANKL.
Yong Deok Lee, Bongjun Kim, Suhan Jung, Haemin Kim, Min Kyung Kim, Jun-Oh Kwon, Min-Kyoung Song, Z. Lee, Hong-Hee Kim   +8 more
semanticscholar   +1 more source

Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration [PDF]

Proceedings of the National Academy of Sciences, 2009
Neurodegenerative disease in humans and mice can be caused by mutations affecting the microtubule motor dynein or its biochemical regulator, dynactin, a multiprotein complex required for dynein function ( 1 – 4 )
Jeffrey K, Moore, David, Sept, John A, Cooper   +2 more
openaire   +2 more sources

m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 8, Page 221-229, December 2025.
ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An, Yuhao Wu, Jingzhe Han, Pingping Fang, Yi Bu, Guang Ji, Jinliang Deng, Xueqin Song   +7 more
wiley   +1 more source

NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

eLife, 2016
Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
Lindsey Seldin, Andrew Muroyama, Terry Lechler   +2 more
doaj   +1 more source

The role of microtubule movement in bidirectional organelle transport [PDF]

, 2008
We study the role of microtubule movement in bidirectional organelle transport in Drosophila S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of motor induced, noisy cytoskeletal motions.
A. E. X. Brown, Amblard, B. Blehm, Baas, C. Kural, Caspi, Gittes, Gross, H. Kim, I. M. Kulic, Keating, Lau, Martin, Orokos, P. C. Nelson, P. R. Selvin, Pangarkar, V. I. Gelfand, Vale, Wang, Welte, Welte   +21 more
core   +4 more sources

HSV‐1 US3: A Master Mimic Hijacking Host Kinase Networks for Viral Dominance

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT Herpes simplex virus type 1 (HSV‐1) encodes the serine/threonine kinase US3, a central regulator of host–virus interactions that promotes viral replication, latency, and reactivation. Despite limited sequence homology to cellular kinases such as Akt or PKA, US3 phosphorylates diverse substrates to manipulate multiple pathways.
Imran Hossain, Christella J. Nelson, Ojasvi Dutta, Harikrishnan Mohan, Mehedi Hasan, Konstantin G. Kousoulas   +5 more
wiley   +1 more source

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

Nature Structural & Molecular Biology, 2017
Cytoplasmic dynein is a protein complex that transports molecular cargo along microtubules (MTs), playing a key role in the intracellular trafficking network.
D. Grotjahn, S. Chowdhury, Yiru Xu, R. Mckenney, T. Schroer, G. Lander   +5 more
semanticscholar   +1 more source

Structure and function of dynactin

Seminars in Cell & Developmental Biology, 1996
Abstract Dynactin is a 1·2 mDa protein complex initially isolated as an activator of cytoplasmic dynein-driven vesicle movementin vitro. Genetic studies have verified that dynactin participates in dynein-based transport events as varied as nuclear localization and axonal transport.
openaire   +1 more source

Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity [PDF]

Journal of Neurochemistry, 2012
J. Neurochem. (2012) 122, 162–174.AbstractGlutamate excitotoxicity causes neuronal dysfunction and degeneration. It is implicated in chronic disorders, including Alzheimer’s disease, and in acute CNS insults such as ischemia. These disorders share prominent morphological features, including axon degeneration and cell body death.
Takeshi, Fujiwara, Koji, Morimoto, Akiyoshi, Kakita, Hitoshi, Takahashi   +3 more
openaire   +2 more sources

Postnatal Mouse Brain Region‐Resolved Peptidomic Resource of Conditional Ndel1 Loss: Comparison of Acidic and Alcoholic Extraction Strategies

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
The Ndel1 protein is crucial for neurodevelopment, but its role in the brain peptidome is unknown. Here we compared the peptidome of Ndel1 conditional knockout (Ndel1_cKO) mice with controls (CTRL) in four brain regions. Peptides were extracted using acidic (Acetic Acid, AcOH) and organic (Methanol, MeOH) methods and analyzed by Liquid Chromatography ...
João V. Nani, Jackelinne Yuka Hayashi, Joana D. Campeiro, Guilherme Araújo Câmara, Atsushi Saito, William Y. Oyadomari, Akira Sawa, Atsushi Kamiya, Alexandre K. Tashima, Mirian A. F. Hayashi   +9 more
wiley   +1 more source