Results 91 to 100 of about 63,555 (261)
Advanced Science, EarlyView.This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou +17 more
wiley +1 more source
Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]
, 2015 Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Anderson, G +14 more
core +1 more source
Synaptic Vesicle Dynamics sans Dynamin [PDF]
Neuron, 2007 The neuron-specific guanosine triphosphatase dynamin 1 has been hypothesized to be critically required for pinching off synaptic vesicles during endocytosis. In a recent publication in Science, Ferguson et al. describe a series of experiments demonstrating an unexpectedly selective requirement of dynamin 1 in synaptic vesicle endocytosis only during ...
openaire +4 more sources
Advanced Science, EarlyView.Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li +8 more
wiley +1 more source
Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor
Membranes, 2015 The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
doaj +1 more source
Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion [PDF]
, 2020 Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Arrizabalaga, Gustavo +2 more
core +1 more source
Dynamin and receptor‐mediated endocytosis [PDF]
FEBS Letters, 1996 The internalization of receptor‐bound ligands involves concentration of cell surface receptors in specialized areas of the plasma membrane and subsequent formation of clathrin‐coated vesicles. The complex process of invagination, constriction and budding of clathrin‐coated vesicles employs the coordinated actions of several proteins.
openaire +2 more sources
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Pharmaceuticals, 2020 The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment.
Anna A. Plyasova +7 more
doaj +1 more source
Pathophysiological Role of Caveolae in Hypertension [PDF]
, 2019 Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver +4 more
core +2 more sources