Results 241 to 250 of about 50,252 (279)

Phosphorylation of dynamin I and synaptic-vesicle recycling

Trends in Neurosciences, 1994
In nerve terminals, neurotransmitters are packaged in synaptic vesicles, and released by exocytosis. Empty synaptic vesicles are rapidly recycled for reuse by endocytosis. Much progress has been made in identifying the proteins involved in synaptic-vesicle trafficking, but the mechanism and regulation of endocytosis have largely remained an enigma. One
P J, Robinson, J P, Liu, K A, Powell, E M, Fykse, T C, Südhof   +4 more
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Genetic Studies on Dynamin Function inDrosophila

Journal of Neurogenetics, 1993
The shibire(ts2) mutation of Drosophila melanogaster causes a temperature sensitive inhibition of endocytosis; this in turn leads to synaptic-vesicle depletion and consequent paralysis. Heat-pulses delivered during development of shibire(ts2) individuals affect the morphology of a number of adult structures. A simple screening protocol has been used to
M, Ramaswami, S, Rao, A, van der Bliek, R B, Kelly, K S, Krishnan   +4 more
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Calcium Binds Dynamin I and Inhibits Its GTPase Activity

Journal of Neurochemistry, 1996
Abstract: Synaptic vesicle recycling is a neuronal specialization of endocytosis that requires the GTPase activity of dynamin I and is triggered by membrane depolarization and Ca2+ entry. To establish the relationship between dynamin I GTPase activity and Ca2+, we used purified dynamin I and analyzed its interaction with Ca2+ in vitro.
J P, Liu, Q X, Zhang, G, Baldwin, P J, Robinson   +3 more
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1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity

Organic & Biomolecular Chemistry, 2015
Fragment-basedin silicoscreening against dynamin I (dynI) GTPase activity identified the 1,8-naphthalimide framework as a potential scaffold for the design of new inhibitors targeting the GTP binding pocket of dynI.
Abdel-Hamid, Mohammed K., Macgregor, Kylie A., Odell, Luke R., Chau, Ngoc, Mariana, Anna, Whiting, Ainslie, Robinson, Phillip J., McCluskey, Adam   +7 more
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Resistance of Paramyxoviridae to Type I Interferon-InducedBos taurusMx1 Dynamin

Journal of Interferon & Cytokine Research, 2005
Typical targets of type I interferon (IFN)-induced antiviral Mx proteins known to date have been shown to share a common profile: single-stranded negative-sense RNA viruses. Among them, human MxA is known to interfere with the replication of measles, human, and bovine parainfluenza-3 viruses (BoPi3V), that is, three members of the Paramyxoviridae ...
Leroy, Michael, Baise, Etienne, Pire, Grégory, Gérardin, Joël, Desmecht, Daniel   +4 more
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Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II

Molecular Pharmacology, 2007
Dynamin is a GTPase enzyme involved in membrane constriction and fission during endocytosis. Phospholipid binding via its pleckstrin homology domain maximally stimulates dynamin activity. We developed a series of surface-active small-molecule inhibitors, such as myristyl trimethyl ammonium bromide (MiTMAB) and octadecyltrimethyl ammonium bromide ...
Quan, Annie, McGeachie, Andrew B., Keating, Damien J., van Dam, Ellen M., Rusak, Jenny, Chau, Ngoc, Malladi, Chandra S., Chen, Chen, McCluskey, Adam, Cousin, Michael A., Robinson, Phillip J.   +10 more
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Rapid Purification of Native Dynamin I and Colorimetric GTPase Assay

2005
Dynamin I is a large GTPase enzyme required in membrane constriction and fission during multiple forms of endocytosis. The first method described here is for the rapid purification of native dynamin from peripheral membrane extracts of sheep brain using ammonium sulfate precipitation and affinity purification on recombinant SH3 domains.
Annie, Quan, Phillip J, Robinson
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Dynamin- and clathrin-dependent endocytic pathway in unicellular eukaryote Paramecium

Biochemistry and Cell Biology, 2004
The first evidence of dynamin presence and its colocalization with clathrin in the compartment involved in Paramecium receptor-mediated endocytosis is presented. We identified dynamin by cloning, Western blotting, and immunodetection in confocal and electron microscopy. The partial genes, which we have designated ParDyn1 and ParDyn2, are 1091 bp long,
Jolanta, Wiejak, Liliana, Surmacz, Elzbieta, Wyroba   +2 more
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Iminochromene Inhibitors of Dynamins I and II GTPase Activity and Endocytosis

Journal of Medicinal Chemistry, 2010
Herein we report the synthesis of discrete iminochromene ("iminodyn") libraries (14-38) as potential inhibitors of dynamin GTPase. Thirteen iminodyns were active (IC(50) values of 260 nM to 100 microM), with N,N-(ethane-1,2-diyl)bis(7,8-dihydroxy-2-iminochromene-3-carboxamide) (17), N,N-(ethane-1,2-diyl)bis(7,8-dihydroxy-2-iminochromene-3-carboxamide) (
Hill, Timothy A., Mariana, Anna, McCluskey, Adam, Gordon, Christopher P., Odell, Luke R., Robertson, Mark J., McGeachie, Andrew B., Chau, Ngoc, Daniel, James A., Gorgani, Nick N., Robinson, Phillip J.   +10 more
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