Results 11 to 20 of about 4,209 (249)
Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]
Microbial Cell, 2016 The dynamins represent a superfamily of proteins that have been shown to function in a wide range of membrane fusion and fission events. An increasing number of mutations in the human classical dynamins, Dyn-1 and Dyn-2 has been reported, with diseases ...
Laila Moustaq +4 more
doaj +6 more sources
Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1. [PDF]
PLoS ONE, 2014 Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 activation is a complex process that involves translocation from the cytosol to the mitochondrial ...
Itsasne Bustillo-Zabalbeitia +5 more
doaj +1 more source
Traffic, 2006 Animal and plant cytokineses appear morphologically distinct. Recent studies, however, have revealed that these cellular processes have many things in common, including the requirement of co‐ordinated membrane trafficking and cytoskeletal dynamics. At the intersection of these two processes are the members of the dynamin family of ubiquitous eukaryotic
Catherine A, Konopka +3 more
openaire +2 more sources
eLife, 2022 Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau)
Tetsuya Hori +9 more
doaj +1 more source
Current Biology, 2018 The dynamin superfamily comprises a growing assortment of multi-domain GTPases, found from bacteria to man, that are distinguished from typical GTPases of the Ras, Rab and G-protein families by their modular structure (Figure 1), relatively large size (>70 kDa), and low affinity for guanine nucleotides.
Rajesh, Ramachandran, Sandra L, Schmid
openaire +2 more sources
A highly-sensitive high throughput assay for dynamin's basal GTPase activity. [PDF]
PLoS ONE, 2017 Clathrin-mediated endocytosis is the major pathway by which cells internalize materials from the external environment. Dynamin, a large multidomain GTPase, is a key regulator of clathrin-mediated endocytosis.
Aparna Mohanakrishnan +5 more
doaj +1 more source
Dynamin recruitment by clathrin coats: a physical step? [PDF]
, 2003 Recent structural findings have shown that dynamin, a cytosol protein playing a key-role in clathrin-mediated endocytosis, inserts partly within the lipid bilayer and tends to self-assemble around lipid tubules. Taking into account these observations, we
Dommersnes, P. -G. +2 more
core +2 more sources
Structure and function of bacterial dynamin-like proteins [PDF]
, 2012 Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core +1 more source
Journal of Integrative Agriculture, 2023 Fusarium head blight (FHB) caused by Fusarium graminearum is a devastating fungal disease on small grain cereal crops, because it reduces yield and quality and causes the mycotoxin contamination to the grain.
Jin-bo KANG +7 more
doaj +1 more source
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation [PDF]
, 2010 The dynamin-related GTPase OPA1 is mutated in autosomal dominant optic atrophy (DOA) (Kjer type), an inherited neuropathy of the retinal ganglion cells.
Alexander +28 more
core +3 more sources