Syntaphilin Binds to Dynamin-1 and Inhibits Dynamin-dependent Endocytosis [PDF]
Journal of Biological Chemistry, 2003 Syntaphilin is a brain-specific syntaxin-binding partner first characterized as an inhibitor of SNARE complex formation and neurotransmitter release. Here we show that syntaphilin also binds to dynamin-1 and through this interaction inhibits dynamin-mediated endocytosis. Immunoprecipitation studies from cross-linked rat synaptosomes demonstrate that an
Sunit, Das +2 more
openaire +2 more sources
Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease [PDF]
, 2016 In Huntington's disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein huntingtin (htt) leads to neurodegeneration in specific brain areas.
Fernández-Chacón, Rafael +4 more
core +5 more sources
A proteomic study of memory after imprinting in the domestic chick
Frontiers in Behavioral Neuroscience, 2015 The intermediate and medial mesopallium (IMM) of the domestic chick forebrain has previously been shown to be a memory system for visual imprinting. Learning-related changes occur in certain plasma membrane and mitochondrial proteins in the IMM.
Maia eMeparishvili +6 more
doaj +1 more source
Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors
Molecules, 2022 Acetylcholinesterase (AChE) is one of the classical targets in the treatment of Alzheimer’s disease (AD). Inhibition of AChE slows down the hydrolysis of acetycholine and increases choline levels, improving the cognitive function. The achieved success of
Mariyana Atanasova +6 more
doaj +1 more source
mBio, 2022 Bacillus subtilis DynA is a member of the dynamin superfamily, involved in membrane remodeling processes. DynA was shown to catalyze full membrane fusion and it plays a role in membrane surveillance against antibiotics.
Lijun Guo +4 more
doaj +1 more source
Dynamin-Like Protein B of Dictyostelium Contributes to Cytokinesis Cooperatively with Other Dynamins
Cells, 2019 Dynamin is a large GTPase responsible for diverse cellular processes, such as endocytosis, division of organelles, and cytokinesis. The social amoebozoan, Dictyostelium discoideum, has five dynamin-like proteins: dymA, dymB, dlpA, dlpB, and dlpC.
Koushiro Fujimoto +8 more
doaj +1 more source
Identification of novel NPRAP/δ-catenin-interacting proteins and the direct association of NPRAP with dynamin 2. [PDF]
PLoS ONE, 2011 Neural plakophilin-related armadillo protein (NPRAP or δ-catenin) is a neuronal-specific protein that is best known for its interaction with presenilin 1 (PS1).
Carolina Koutras, Georges Lévesque
doaj +1 more source
Dynamins maintain nuclear envelope homeostasis and genome stability
Nature CommunicationsThe nuclear envelope is a protective barrier for the genome and a mechanotransduction interface between cytoplasm and nucleus, whose malfunction disrupts nucleocytoplasmic transport, compromises DNA repair, accelerates telomere shortening, and promotes ...
Célia Aveleira +13 more
doaj +1 more source
LeoA, B and C from enterotoxigenic Escherichia coli (ETEC) are bacterial dynamins.
PLoS ONE, 2014 Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion.
Katharine A Michie +4 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source