Results 91 to 100 of about 18,529 (254)

A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. [PDF]

, 2015
Corticotrophin-releasing factor (CRF) is a 41 amino acid neuropeptide that coordinates adaptive responses to stress. CRF projections from neurons in the central nucleus of the amygdala (CeA) to the brainstem are of particular interest for their role in ...
Blasio, Angelo, Crawford, Elena, Dadgar, Jahan, De Guglielmo, Giordano, George, Olivier, Hopf, F Woodward, Janak, Patricia H, Keiflin, Ronald, Kharazia, Viktor, Maiya, Rajani, Messing, Robert O, Millan, E Zayra, Pomrenze, Matthew B, Rice, Kenner C   +13 more
core   +2 more sources

Alterations in Cortical and Basal Ganglia Levels of Opioid Receptor Binding in a Rat Model of l-DOPA-Induced Dyskinesia

Neurobiology of Disease, 2001
Opioid receptor-binding autoradiography was used as a way to map sites of altered opioid transmission in a rat model of l-DOPA-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathways sustained a 3-week treatment ...
P.A. Johansson, M. Andersson, K.E. Andersson, M.A. Cenci   +3 more
doaj  

Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A

Neural Plasticity, 2020
Background. Visceral pain is one of the most common types of pain and particularly in the abdomen is associated with gastrointestinal diseases. Bulleyaconitine A (BAA), isolated from Aconitum bulleyanum, is prescribed in China to treat chronic pain.
Sheng-Nan Huang, Jinbao Wei, Lan-Ting Huang, Pei-Jun Ju, Jinghong Chen, Yong-Xiang Wang   +5 more
doaj   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Dynorphin induced magnetic ordering in lipid bilayers as studied by 31P NMR spectroscopy [PDF]

, 2002
Lipid bilayers of dimyristoyl phosphatidylcholine (DMPC) containing opioid peptide dynorphin A(1–17) are found to be spontaneously aligned to the applied magnetic field near at the phase transition temperature between the gel and liquid crystalline ...
Nagao, Takashi, Naito, Akira, Obata, Maki, Okamoto, Manabu, Saitô, Hazime, Shindo, Yuriko, Tuzi, Satoru, Yokoyama, Shinya   +7 more
core   +1 more source

Brain‐Specific Gata4 Downregulation in Greywick Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
In adult Gw female mice, competition between transgenic and endogenous Gata4 promoters leads to decreased Gata4 expression in the hypothalamus while it remains unaffected in the ovaries. The resulting PCOS‐like traits, combining reproductive and metabolic dysfunctions in these mice, support a central (CNS)—not peripheral (ovarian)—mechanism of disease ...
Sherin A. Nawaito, Mostafa Esmael, Ouliana Souchkova, Tatiana Cardinal, Guillaume Bernas, Karl‐F. Bergeron, Fanny Gayda, Francis Bergeron, Marie‐France Bouchard, Xiang Zhou, Luisina Ongaro, Daniel J. Bernard, Jacob Short, Susan Wray, Robert S. Viger, Catherine Mounier, Nicolas Pilon   +16 more
wiley   +1 more source

Dopaminergic, glutamatergic but not opioidergic mechanisms mediate induction of FOS-like protein by cocaethylene [PDF]

, 1997
Cocaethylene is a psychoactive metabolite formed\ud during the combined consumption of cocaine and ethanol. As\ud this metabolite has many properties in common with cocaine, it is conceivable that cocaethylene administration may induce the activity of ...
DiPirro, Dr. J.M., Horowitz, Dr. J.M., Kristal, Dr. M.B., Torres, Dr. G.   +3 more
core  

Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness. [PDF]

, 2014
UnlabelledWe analyzed the 16S rRNA amplicon composition in fecal samples of selected patients during their prolonged stay in an intensive care unit (ICU) and observed the emergence of ultra-low-diversity communities (1 to 4 bacterial taxa) in 30% of the ...
Alverdy, John C, Garfield, Kevin, Gilbert, Jack A, Kade, Matthew, Quensen, John, Shakhsheer, Baddr, Smith, Daniel, Tiedje, James, Tirrell, Matthew, Zaborin, Alexander, Zaborina, Olga   +10 more
core   +3 more sources

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Phasic Firing in Vasopressin Cells: Understanding Its Functional Significance through Computational Models [PDF]

, 2012
Vasopressin neurons, responding to input generated by osmotic pressure, use an intrinsic mechanism to shift from slow irregular firing to a distinct phasic pattern, consisting of long bursts and silences lasting tens of seconds.
Duncan J. MacGregor, Gareth Leng, Tim Behrens   +2 more
core   +2 more sources