Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Schematic diagram for the excitatory glutamate receptors for morphine tolerance and drugs targeting glutamate receptors in morphine tolerance. This figure illustrates the main mechanisms by which the major ionic and metabotropic glutamatergic receptors are involved in the process of morphine tolerance.
Min Huang +6 more
wiley +1 more source
Individual differences in the neuropsychopathology of addiction. [PDF]
, 2017 Drug addiction or substance-use disorder is a chronically relapsing disorder that progresses through binge/intoxication, withdrawal/negative affect and preoccupation/anticipation stages.
George, Olivier, Koob, George F
core
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.Rapid heat stabilization of brain tissue preserves the natural levels and spatial distribution of neurotransmitters and neuropeptides better than traditional snap freezing. Using matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI), we show that heat stabilization effectively prevents postmortem enzymatic degradation ...
Emanuela Salviati +7 more
wiley +1 more source
5-HT6R Viral Vector-Mediated Indirect Pathway Activation in the Dorsolateral Striatum: A Discussion on Basal Ganglia Habitual and Goal-Directed Circuits [PDF]
, 2018 Altering maladaptive behavioral tendencies is relevant for clinical interventions, making research on underlying mechanisms of habit essential. Mechanisms of habit are explored here with differential activation of the indirect pathway in the basal ...
Winn, Caleb S
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Neuroanatomy of the human hypothalamic kisspeptin system. [PDF]
, 2014 Hypothalamic kisspeptin (KP) neurons are key players in the neuronal network that regulates the onset of puberty and the pulsatile secretion of gonadotropin-releasing hormone (GnRH).
Hrabovszky, Erik
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Prenatal Testosterone Excess Decreases Neurokinin 3 Receptor Immunoreactivity within the Arcuate Nucleus KNDy Cell Population [PDF]
, 2015 Prenatal exposure of the female ovine foetus to excess testosterone leads to neuroendocrine disruptions in adulthood, as demonstrated by defects in responsiveness with respect to the ability of gonadal steroids to regulate gonadotrophin‐releasing hormone
Almeida +58 more
core +2 more sources
TGF-β1 enhances cardiomyogenic differentiation of skeletal muscle-derived adult primitive cells [PDF]
, 2008 The optimal medium for cardiac differentiation of adult primitive cells remains to be established. We quantitatively compared the efficacy of IGF-1, dynorphin B, insulin, oxytocin, bFGF, and TGF-beta1 in inducing cardiomyogenic differentiation.
Abdel-Latif, Ahmed +9 more
core +1 more source
Involvement of dynorphin in anxiogenic effects of estrogen
BMC Pharmacology, 2009 Methods Dyn KO mice were generated by replacement of the entire coding region of the prodynorphin gene [2] and backcrossed onto C57bl/6N. Age and testing experiencematched female intact and ovariectomized (OVX) Dyn KO and wildtype (WT) mice at 3-8 months age were tested in all experiments.
Christoph Schwarzer +3 more
openaire +2 more sources
Arcuate nucleus homeostatic systems reflect blood leptin concentration but not feeding behaviour during scheduled feeding on a high-fat diet in mice [PDF]
, 2017 Acknowledgements T.B. was funded by a CASE studentship from the BBSRC and AstraZeneca. J.B. was a summer student from Bordeaux Sciences Agro and funded by student laboratory experience grant from the British Society of Neuroendocrinology. The authors are
Bake, T. +4 more
core +1 more source
Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice [PDF]
, 2018 Restraint stress is a psychosocial stressor that suppresses reproductive status, including LH pulsatile secretion, but the neuroendocrine mechanisms underlying this inhibition remains unclear.
Hughes, Jessica K +4 more
core +1 more source