Results 101 to 110 of about 18,857 (274)

Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception [PDF]

, 2004
Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating ...
DiPirro, Jean M., Kristal, Dr. Mark B.
core  

Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]

, 2019
Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
core   +1 more source

A procedure to identify persistent and effort‐independent individual differences in preference for heroin over rewarding social interaction

British Journal of Pharmacology, Volume 182, Issue 22, Page 5596-5610, November 2025.
Background and Purpose In some individuals, opioid use leads to decreased interest in socially relevant rewards. Recent studies showed that after extended‐access heroin self‐administration, rats strongly prefer social interaction over single unit‐dose heroin infusions.
Ginevra D'Ottavio, Alana Sullivan, Sara Pezza, Maria Chiara Ruano, Jacopo Modoni, Ingrid Reverte, Claudia Marchetti, Soami F. Zenoni, Marco Venniro, Michele S. Milella, Fernando Boix, Yavin Shaham, Daniele Caprioli   +12 more
wiley   +1 more source

Targeting G9a decreases escalated alcohol drinking in male mice in a model of combined stress and chronic alcohol exposure

Alcohol, Clinical and Experimental Research, Volume 49, Issue 10, Page 2267-2277, October 2025.
Targeting dependence‐ and/or stress‐escalated alcohol drinking could help patients with alcohol use disorder (AUD). We found that reducing the activity of the epigenetic regulatory enzyme G9a (aka euchromatic histone‐lysine N‐methyltransferase 2 or EHMT2) either by a viral knockdown in the nucleus accumbens (NAc) or by repeated systemic administration ...
Marcelo F. Lopez, Paulina Misztak, Howard C. Becker, Christopher W. Cowan, Ethan M. Anderson   +4 more
wiley   +1 more source

Pain Perception and Modulation: Fundamental Neurobiology and Recent Advances

European Journal of Neuroscience, Volume 62, Issue 8, October 2025.
Chronic pain is a major burden with variable treatment responses reflecting complex biopsychosocial and neurobiological factors. This narrative review synthesizes evidence on neural structures, circuits, and mediators involved in pain perception and modulation.
Willem W. J. van Strien, Markus W. Hollmann   +1 more
wiley   +1 more source

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides [PDF]

, 2016
Background During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti- inflammatory M2 populations ...
Batra, Arvind, Celik, Melih O., Keye, Jacqueline, Labuz, Dominika, Machelska, Halina, Pannell, Maria, Siegmund, Britta   +6 more
core   +2 more sources

The Causal Relationship Between Circulating Inflammatory Proteins and Tinnitus: A Mendelian Randomization Study Mediated by Blood Metabolites

Brain and Behavior, Volume 15, Issue 9, September 2025.
This Mendelian randomization study reveals that elevated CCL19 increases tinnitus risk via pantothenate‐mediated inflammation, implicating the CCL19‐pantothenate‐TLR4/NF‐κB axis as a causal pathway. Findings identify novel biomarkers for early tinnitus prediction and highlight metabolic‐inflammation interplay in pathogenesis.
Keyu Chen, Yuankun Cai
wiley   +1 more source

Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit

Cell Reports, 2016
Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described.
Nicole A. Crowley, Daniel W. Bloodgood, J. Andrew Hardaway, Alexis M. Kendra, Jordan G. McCall, Ream Al-Hasani, Nora M. McCall, Waylin Yu, Zachary L. Schools, Michael J. Krashes, Bradford B. Lowell, Jennifer L. Whistler, Michael R. Bruchas, Thomas L. Kash   +13 more
doaj   +1 more source

Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides [PDF]

, 2015
Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ...
Beaudry, Francis, Saidi, Mouna
core   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source