Results 31 to 40 of about 18,857 (274)

Stress-induced reinstatement of nicotine preference requires dynorphin/kappa opioid activity in the basolateral amygdala [PDF]

, 2016
UNLABELLED: The dynorphin (DYN)/kappa-opioid receptor (KOR) system plays a conserved role in stress-induced reinstatement of drug seeking for prototypical substances of abuse.
Bruchas, Michael R, Carlezon, William A, Hourguettes, Nicholas J, Nygard, Stephanie K, Sobczak, Gabe G   +4 more
core   +2 more sources

Circuit dissection of the role of somatostatin in itch and pain [PDF]

, 2018
Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood.
AJ Christensen, AJ Todd, Allen C. Dickie, AM Bell, Andrew J. Todd, AP Kardon, B Duan, BL Roth, BN Armbruster, C Peirs, C Solorzano, CE Pichon Le, CL Li, D Bröhl, D Usoskin, DM Bautista, DP Roberson, DR Simmons, E Foster, E Polgár, E Vasyutina, Erika Polgár, F Cevikbas, F Proudlock, GR Dressler, H Petitjean, H Taniguchi, Hanns Ulrich Zeilhofer, Hans Jürgen Solinski, Hendrik Wildner, I Bencivinni, IM Chiu, J Braz, J Chrubasik, Jing Huang, JL Hylden, John S. Riddell, KA Boyle, Kieran A. Boyle, KK Stantcheva, L Cui, L Han, L Li, L Madisen, L Madisen, M Gutierrez-Mecinas, M Gutierrez-Mecinas, M Gutierrez-Mecinas, Mark A. Hoon, Masahiko Watanabe, Mette C. Kriegbaum, MJ Krashes, MQ Nguyen, Noboru Iwagaki, P Taurà, Pang-Yen Tseng, PS Danielian, RJ Mullen, S Sun, Santosh K. Mishra, SE Ross, SK Mishra, SK Mishra, SK Mishra, SM Carlton, SM Carlton, SR Chaplan, T Akiyama, T Hökfelt, T Hökfelt, T Lee, T Yasaka, T Zeyda, V Chapman, VE Abraira, VS Seybold, Y Lu, YG Sun, YG Sun, Z Wiesenfeld-Hallin   +79 more
core   +1 more source

Modulation of feeding behavior and metabolism by dynorphin [PDF]

Scientific Reports, 2020
AbstractThe neuronal regulation of metabolic and behavioral responses to different diets and feeding regimens is an important research area. Herein, we investigated if the opioid peptide dynorphin modulates feeding behavior and metabolism. Mice lacking dynorphin peptides (KO) were exposed to either a normal diet (ND) or a high-fat diet (HFD) for a ...
Andreas Zimmer, Ildiko Racz, Aishwarya Ghule, Andras Bilkei-Gorzo, Este Leidmaa, Meike Sieburg, Meike Sieburg   +6 more
openaire   +4 more sources

Dynorphin is expressed primarily by GABAergic neurons that contain galanin in the rat dorsal horn

Molecular Pain, 2011
Background The opioid peptide dynorphin is expressed by certain neurons in the superficial dorsal horn of the spinal cord, but little is known about the types of cell that contain dynorphin.
Kaneko Takeshi, Furuta Takahiro, Garzillo Francesca, Polgár Erika, Sardella Thomas CP, Watanabe Masahiko, Todd Andrew J   +6 more
doaj   +1 more source

The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]

, 2019
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A, Kauffman, Alexander S   +1 more
core   +1 more source

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Bloom, Stephen R., Borsay, Beáta Á., Ciofi, Philippe, Dhillo, Waljit S., Ghatei, Mohammad A., Herczeg, László, Hrabovszky, Erik, Liposits, Zsolt, Molnár, Csilla S., Rácz, Kálmán, Sipos, Máté T., Vida, Barbara   +11 more
core   +1 more source

Dynorphin: friend or foe?

Pain, 2000
Pain 87 (2000) 235-239. doi:10.1016/S0304-3959(00)00360-2 ; Received by publisher: 2000-05-22 ; Harvest Date: 2016-01-04 12:22:07 ; DOI:10.1016/S0304-3959(00)00360-2 ; Page Range: 235 ...
Department of Oral Surgery, Division of Neuroscience, University of Florida College of Dentistry, P.O. Box 100416, Gainesville, FL 32610, USA ( host institution ), Caudle, Robert M. ( author ), Mannes, Andrew J. ( author )   +2 more
openaire   +4 more sources

Immunoreactive dynorphin in pituitary and brain. [PDF]

Proceedings of the National Academy of Sciences, 1980
Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland (pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly specific antiserum. By gel permeation chromatography in 4 M guanidine, the porcine pituitary immunoreactivity is found in a major peak of apparent molecular weight ...
Avram Goldstein, Vartan E. Ghazarossian
openaire   +3 more sources

Rapid-Onset Anti-Stress Effects of a Kappa-Opioid Receptor Antagonist, LY2795050, Against Immobility in an Open Space Swim Paradigm in Male and Female Mice

Frontiers in Pharmacology, 2021
The kappa-opioid receptor (KOR) / dynorphin system is implicated with behavioral and neurobiological effects of stress exposure (including heavy exposure to drugs of abuse) in translational animal models.
Caroline Baynard, Thomas E. Prisinzano, Eduardo R. Butelman   +2 more
doaj   +1 more source

Pathobiology of dynorphins in trauma and disease [PDF]

Frontiers in Bioscience, 2005
Dynorphins, endogenous opioid neuropeptides derived from the prodynorphin gene, are involved in a variety of normative physiologic functions including antinociception and neuroendocrine signaling, and may be protective to neurons and oligodendroglia via their opioid receptor-mediated effects. However, under experimental or pathophysiological conditions
Stephen W. Scheff, Bryce Vissel, Indrapal N. Singh, Jane V. Aldrich, Pamela E. Knapp, MacDonald J. Christie, Tatiana Yakovleva, Kevin J. Anderson, Kurt F. Hauser, Georgy Bakalkin, Amina S. Woods, Toni S. Shippenberg, Edward D. Hall   +12 more
openaire   +3 more sources