Results 31 to 40 of about 18,529 (254)

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]

open access: yes, 1984
Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
B Sutor   +11 more
core   +1 more source

Rapid-Onset Anti-Stress Effects of a Kappa-Opioid Receptor Antagonist, LY2795050, Against Immobility in an Open Space Swim Paradigm in Male and Female Mice

open access: yesFrontiers in Pharmacology, 2021
The kappa-opioid receptor (KOR) / dynorphin system is implicated with behavioral and neurobiological effects of stress exposure (including heavy exposure to drugs of abuse) in translational animal models.
Caroline Baynard   +2 more
doaj   +1 more source

Dynorphin: friend or foe?

open access: yesPain, 2000
Pain 87 (2000) 235-239. doi:10.1016/S0304-3959(00)00360-2 ; Received by publisher: 2000-05-22 ; Harvest Date: 2016-01-04 12:22:07 ; DOI:10.1016/S0304-3959(00)00360-2 ; Page Range: 235 ...
Department of Oral Surgery, Division of Neuroscience, University of Florida College of Dentistry, P.O. Box 100416, Gainesville, FL 32610, USA ( host institution )   +2 more
openaire   +4 more sources

Immunoreactive dynorphin in pituitary and brain. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1980
Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland (pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly specific antiserum. By gel permeation chromatography in 4 M guanidine, the porcine pituitary immunoreactivity is found in a major peak of apparent molecular weight ...
Avram Goldstein, Vartan E. Ghazarossian
openaire   +3 more sources

Prenatal programming of neuroendocrine reproductive function [PDF]

open access: yes, 2016
It is now well recognized that the gestational environment can have long-lasting effects not only on the life span and health span of an individual but also, through potential epigenetic changes, on future generations.
Bellingham, Michelle   +2 more
core   +1 more source

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

open access: yesJournal of Neuroinflammation, 2012
Background The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear.
Wang Qingshan   +8 more
doaj   +1 more source

Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects

open access: yesFrontiers in Pharmacology, 2021
Addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (D2r) signaling. However, the effects of chronic cocaine on neuronal adaptations in this system have not been systematically ...
Kevin Clare   +7 more
doaj   +1 more source

Pathobiology of dynorphins in trauma and disease [PDF]

open access: yesFrontiers in Bioscience, 2005
Dynorphins, endogenous opioid neuropeptides derived from the prodynorphin gene, are involved in a variety of normative physiologic functions including antinociception and neuroendocrine signaling, and may be protective to neurons and oligodendroglia via their opioid receptor-mediated effects. However, under experimental or pathophysiological conditions
Stephen W. Scheff   +12 more
openaire   +3 more sources

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

open access: yeseLife, 2016
Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1ARH) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide ...
Jian Qiu   +6 more
doaj   +1 more source

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]

open access: yes, 2013
Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core   +1 more source

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