Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]
, 2017 The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core +1 more source
Cell Reports, 2019 Summary: Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning. These CeACRF neurons release GABA and several neuropeptides predicted to play important yet opposing roles in these behaviors ...
Matthew B. Pomrenze +5 more
doaj +1 more source
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
Stress-induced reinstatement of nicotine preference requires dynorphin/kappa opioid activity in the basolateral amygdala [PDF]
, 2016 UNLABELLED: The dynorphin (DYN)/kappa-opioid receptor (KOR) system plays a conserved role in stress-induced reinstatement of drug seeking for prototypical substances of abuse.
Bruchas, Michael R +4 more
core +2 more sources
Circuit dissection of the role of somatostatin in itch and pain [PDF]
, 2018 Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood.
AJ Christensen +79 more
core +1 more source
Frontiers in Pharmacology, 2022 Substance use disorders (SUD) may emerge from an individual’s attempt to limit negative affective states and symptoms linked to stress. Indeed, SUD is highly comorbid with chronic stress, traumatic stress, or post-traumatic stress disorder (PTSD), and ...
Claire Leconte +2 more
doaj +1 more source
Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]
, 1984 Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
B Sutor +11 more
core +1 more source
Endogenous Opioids in Crohn’s Disease
Biomedicines, 2023 Caring for patients with Crohn’s disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy.
Adrian Martyniak +2 more
doaj +1 more source
Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]
, 2012 Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Bloom, Stephen R. +11 more
core +1 more source
Dynorphin is expressed primarily by GABAergic neurons that contain galanin in the rat dorsal horn
Molecular Pain, 2011 Background The opioid peptide dynorphin is expressed by certain neurons in the superficial dorsal horn of the spinal cord, but little is known about the types of cell that contain dynorphin.
Kaneko Takeshi +6 more
doaj +1 more source