Results 41 to 50 of about 18,611 (228)

Alterations in Cortical and Basal Ganglia Levels of Opioid Receptor Binding in a Rat Model of l-DOPA-Induced Dyskinesia

Neurobiology of Disease, 2001
Opioid receptor-binding autoradiography was used as a way to map sites of altered opioid transmission in a rat model of l-DOPA-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathways sustained a 3-week treatment ...
P.A. Johansson, M. Andersson, K.E. Andersson, M.A. Cenci   +3 more
doaj   +1 more source

Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats

Journal of Functional Morphology and Kinesiology, 2022
Physical activity (PA) is a non-invasive, cost-effective means of reducing chronic disease. Most US citizens fail to meet PA guidelines, and individuals experiencing chronic stress are less likely to be physically active.
Kolter B. Grigsby, Nathan R. Kerr, Taylor J. Kelty, Xuansong Mao, Thomas E. Childs, Frank W. Booth   +5 more
doaj   +1 more source

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

Journal of Neuroinflammation, 2012
Background The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear.
Wang Qingshan, Shin Eun-Joo, Nguyen Xuan-Khanh, Li Quan, Bach Jae-Hyung, Bing Guoying, Kim Won-Ki, Kim Hyoung-Chun, Hong Jau-Shyong   +8 more
doaj   +1 more source

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Biomedicines, 2021
Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi   +6 more
doaj   +1 more source

The role of BDNF/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum

Frontiers in Systems Neuroscience, 2011
Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty, Alexandra J Bache, Nortorious T Coleman, Wei-Lun eSun   +3 more
doaj   +1 more source

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
doaj   +1 more source

Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion-extension movements [PDF]

, 2008
The present research investigates factors contributing to bradykinesia in the control of simple and complex voluntary limb movement in Parkinson’s disease (PD) patients.
Geelen, J.A.G., Heida, Tjitske, Moroney, Rachel, Rinzel, J.   +3 more
core   +4 more sources

Ester hydrolysis differentially reduces aconitine-induced anti-hypersensitivity and acute neurotoxicity: Involvement of spinal microglial dynorphin expression and implications for Aconitum processing

Frontiers in Pharmacology, 2016
Aconitines, including bulleyaconitine A, probably the most bioactive and abundant alkaloids in Aconitum plant, are a group of diester C19-diterpenoid alkaloids with one acetylester group attached to C8 of the diterpenoid skeleton and one benzoylester ...
Teng-Fei Li, Yong-Xiang Wang, Nian Gong
doaj   +1 more source

Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary [PDF]

, 1982
A 4,000-dalton dynorphin was isolated from porcine pituitary. It has 32 amino acids (Mr = 3,986), with the previously described heptadecapeptide (now called dynorphin A) at its amino terminus and a related tridecapeptide, dynorphin B, at its carboxyl ...
Fischli, Walter, Goldstein, Avram, Hood, Leroy E., Hunkapiller, Michael W.   +3 more
core  

A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. [PDF]

, 2015
Corticotrophin-releasing factor (CRF) is a 41 amino acid neuropeptide that coordinates adaptive responses to stress. CRF projections from neurons in the central nucleus of the amygdala (CeA) to the brainstem are of particular interest for their role in ...
Blasio, Angelo, Crawford, Elena, Dadgar, Jahan, De Guglielmo, Giordano, George, Olivier, Hopf, F Woodward, Janak, Patricia H, Keiflin, Ronald, Kharazia, Viktor, Maiya, Rajani, Messing, Robert O, Millan, E Zayra, Pomrenze, Matthew B, Rice, Kenner C   +13 more
core   +2 more sources