Journal of Neuroscience, 2019 Cocaine-driven changes in the modulation of neurotransmission by neuromodulators are poorly understood. The ventral pallidum (VP) is a key structure in the reward system, in which GABA neurotransmission is regulated by opioid neuropeptides, including ...
Kineret Inbar +5 more
semanticscholar +1 more source
A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states [PDF]
, 2007 Activity-dependent changes in neurons of the rat superficial dorsal horn are crucial for the induction and maintenance of neuropathic and inflammatory pain states.
Geranton, SM +2 more
core +1 more source
Pathobiology of dynorphins in trauma and disease [PDF]
Frontiers in Bioscience, 2005 Dynorphins, endogenous opioid neuropeptides derived from the prodynorphin gene, are involved in a variety of normative physiologic functions including antinociception and neuroendocrine signaling, and may be protective to neurons and oligodendroglia via their opioid receptor-mediated effects. However, under experimental or pathophysiological conditions
Kurt F, Hauser +12 more
openaire +2 more sources
Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet +4 more
wiley +1 more source
Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds
eLife, 2016 Prairie vole breeder pairs form monogamous pair bonds, which are maintained through the expression of selective aggression toward novel conspecifics.
Shanna L Resendez +13 more
doaj +1 more source
Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy
EMBO Molecular Medicine, 2019 Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges.
A. Agostinho +10 more
semanticscholar +1 more source
Concentration–QTc Modeling to Support Clinical Development of Fezolinetant
Clinical Pharmacology in Drug Development, EarlyView.Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen +6 more
wiley +1 more source
Cell Cycle, 2018 Dynorphins act as endogenous anticonvulsants via activation of kappa opioid receptor (KOR). However, the mechanism underlying the anticonvulsant role remains elusive.
H. Dai +5 more
semanticscholar +1 more source
Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]
, 2013 Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core +1 more source
Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms. [PDF]
, 2020 Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones.
Biglia, Nicoletta +14 more
core +4 more sources