Results 91 to 100 of about 10,432 (275)
Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Schematic diagram for the excitatory glutamate receptors for morphine tolerance and drugs targeting glutamate receptors in morphine tolerance. This figure illustrates the main mechanisms by which the major ionic and metabotropic glutamatergic receptors are involved in the process of morphine tolerance.
Min Huang +6 more
wiley +1 more source
Nefrología (English Edition), 2023 Introduction: Pruritus associated with chronic kidney disease is defined as the sensation of itching, in people with chronic kidney disease, in a one area or all over the body that causes the need to scratch, after having ruled out other dermatological ...
Marian Goicoechea +12 more
doaj
Nefrología, 2023 Resumen: Introducción: El prurito asociado a enfermedad renal crónica se define como la sensación desagradable que provoca la necesidad de rascarse en una parte del cuerpo o en todo en personas con enfermedad renal crónica, tras haberse descartado otras
Marian Goicoechea +12 more
doaj
The Enteric Neuronal Circuitry: A Key Ignored Player in Nutrient Sensing Along the Gut–Brain Axis
The FASEB Journal, Volume 39, Issue 9, 15 May 2025.The enteric nervous system (ENS) regulates critical physiological functions including gut motility, blood flow, and epithelial secretions. Despite its autonomous ability to execute local functions, its communication with the central nervous system is integral to the maintenance of homeostasis.
Ester Nikolla +4 more
wiley +1 more source
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies [PDF]
, 2014 We designed and synthesized of 1,3,5-trioxazatriquinanes with o- or p-hydroxyphenyl rings as analogs of the κ opioid receptor agonist SYK-146 with m-hydroxyphenyl groups. Although almost all tested compounds did not bind to the opioid receptors, only 17b
Fujii Hideaki +8 more
core +1 more source
COCAINE-BASED SIGNALING CHANGES IN THE NUCLEUS ACCUMBENS, LATERAL HABENULA, AND THALAMUS [PDF]
, 2015 The brain is an extraordinarily complex and organized system. Environmental information reaches the brain via the sensory systems, and this information is processed to interpret and make sense of the world.
Neumann, Peter Alaric
core
A novel non-Opioid binding site for endomorphin-1 [PDF]
, 2016 Endomorphins are natural amidated opioid tetrapeptides with the following structure: Tyr-Pro-Trp-Phe-NH2 (endomorphin-1),and Tyr-Pro-Phe-Phe-NH2 (endomorphin-2).
Benyhe, S. +8 more
core
Involvement of dynorphin in anxiogenic effects of estrogen
BMC Pharmacology, 2009 Methods Dyn KO mice were generated by replacement of the entire coding region of the prodynorphin gene [2] and backcrossed onto C57bl/6N. Age and testing experiencematched female intact and ovariectomized (OVX) Dyn KO and wildtype (WT) mice at 3-8 months age were tested in all experiments.
Christoph Schwarzer +3 more
openaire +2 more sources
The Pathophysiologic Mechanism of Tinnitus [PDF]
, 2016 Tinnitus represents a phantom auditory sensation without an external sound source. The reported prevalence of tinnitus estimates 15-20% in world population.
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core +2 more sources
A dynorphin-like opioid in the central nervous system of an amphibian. [PDF]
, 1982 R I Cone, Alan Goldstein
openalex +1 more source