Results 11 to 20 of about 5,930 (239)

Biophysical analysis of angiotensin II and amyloid-β cross-interaction in aggregation and membrane disruption. [PDF]

FEBS Lett
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Habibnia M, Catalina-Hernandez E, Cabrerizo-Idiazabal M, Barnadas-Rodríguez R, Lopez-Martin M, Peralvarez-Marin A.   +5 more
europepmc   +2 more sources

Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain

Molecules, 2021
Neuropeptides serve as neurohormones and local paracrine regulators that control neural networks regulating behavior, endocrine system and sensorimotor functions. Their expression is characterized by exceptionally restricted profiles.
Olga Nosova, Igor Bazov, Victor Karpyak, Mathias Hallberg, Georgy Bakalkin   +4 more
doaj   +1 more source

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia

npj Parkinson's Disease, 2022
L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal ganglia are affected
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén   +7 more
doaj   +1 more source

Involvement of the Opioid Peptide Family in Cancer Progression

Biomedicines, 2023
Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez, Francisco D. Rodríguez, Rafael Coveñas   +2 more
doaj   +1 more source

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
doaj   +1 more source

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Abstract Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin‐releasing hormone (GnRH) pulse generator necessary for fertility. KNDy neurons are also metabolic sensors controlling the hypothalamic–pituitary‐gonadal (HPG) axis.
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +2 more sources

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]

, 2017
Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar, Andersson, Malin, Bakalkin, Georgy, Bazov, Igor, Druid, Henrik, Dyachok, Oleg, Gerashchenko, Ganna, Kononenko, Olga, Krishtal, Oleg, Mulder, Jan, Rajkowska, Grazyna, Stockmeier, Craig A, Svenningsen, Asa Fex, Verbeek, Dineke S., Watanabe, Hiroyuki, Yakovleva, Tatiana   +15 more
core   +2 more sources

Dynorphin, stress, and depression [PDF]

Brain Research, 2010
Stress is most often associated with aversive states. It rapidly induces the release of hormones and neuropeptides including dynorphin, which activates kappa opioid receptors (KORs) in the central and peripheral nervous systems. In animal models, many aversive effects of stress are mimicked or exacerbated by stimulation of KORs in limbic brain regions.
Allison T, Knoll, William A, Carlezon
openaire   +2 more sources

Endogenous opioid systems alterations in pain and opioid use disorder

Frontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham, Jessica A. Higginbotham, Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Nicolas Massaly, Nicolas Massaly, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón   +11 more
doaj   +1 more source

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source