Results 11 to 20 of about 4,248 (194)

Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain

Molecules, 2021
Neuropeptides serve as neurohormones and local paracrine regulators that control neural networks regulating behavior, endocrine system and sensorimotor functions. Their expression is characterized by exceptionally restricted profiles.
Olga Nosova, Igor Bazov, Victor Karpyak, Mathias Hallberg, Georgy Bakalkin   +4 more
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Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia

npj Parkinson's Disease, 2022
L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal ganglia are affected
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén   +7 more
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Involvement of the Opioid Peptide Family in Cancer Progression

Biomedicines, 2023
Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez, Francisco D. Rodríguez, Rafael Coveñas   +2 more
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Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
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Dynorphin, stress, and depression [PDF]

Brain Research, 2010
Stress is most often associated with aversive states. It rapidly induces the release of hormones and neuropeptides including dynorphin, which activates kappa opioid receptors (KORs) in the central and peripheral nervous systems. In animal models, many aversive effects of stress are mimicked or exacerbated by stimulation of KORs in limbic brain regions.
Allison T, Knoll, William A, Carlezon
openaire   +2 more sources

Endogenous opioid systems alterations in pain and opioid use disorder

Frontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham, Jessica A. Higginbotham, Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Nicolas Massaly, Nicolas Massaly, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón   +11 more
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Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
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Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward

Addiction Neuroscience, 2022
Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR).
Antony D. Abraham, Sanne M. Casello, Benjamin B. Land, Charles Chavkin   +3 more
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Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

Cell & Bioscience, 2020
Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao, Zhiheng Chen   +5 more
doaj   +1 more source