Results 21 to 30 of about 10,432 (275)

Dynorphin, stress, and depression [PDF]

Brain Research, 2010
Stress is most often associated with aversive states. It rapidly induces the release of hormones and neuropeptides including dynorphin, which activates kappa opioid receptors (KORs) in the central and peripheral nervous systems. In animal models, many aversive effects of stress are mimicked or exacerbated by stimulation of KORs in limbic brain regions.
Allison T. Knoll, William A. Carlezon
openaire   +3 more sources

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
doaj   +1 more source

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source

Endogenous opioid systems alterations in pain and opioid use disorder

Frontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham, Jessica A. Higginbotham, Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Nicolas Massaly, Nicolas Massaly, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón   +11 more
doaj   +1 more source

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]

, 2017
Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar, Andersson, Malin, Bakalkin, Georgy, Bazov, Igor, Druid, Henrik, Dyachok, Oleg, Gerashchenko, Ganna, Kononenko, Olga, Krishtal, Oleg, Mulder, Jan, Rajkowska, Grazyna, Stockmeier, Craig A, Svenningsen, Asa Fex, Verbeek, Dineke S., Watanabe, Hiroyuki, Yakovleva, Tatiana   +15 more
core   +1 more source

The Role of Dynorphins in the Cardiovascular System: An Update on Current Knowledge.

Current molecular medicine, 2019
It is well-established that cardiovascular disease continues to represent a growing health problem and significant effort has been spent to elucidate the underlying mechanisms.
Cody Cissom, Jason J Paris, Z. Shariat-Madar   +2 more
semanticscholar   +1 more source

Identification of dynorphin a from zebrafish: A comparative study with mammalian dynorphin A

Neuroscience, 2007
We report the cloning and molecular characterization of the zfPDYN. The complete open reading frame for this propeptide is comprised in two exons that are localized on chromosome 23. zfPDYN cDNA codes for a polypeptide of 252 amino acids that contains the consensus sequences for four opioid peptides: an Ile-enkephalin, the neo-endorphins, dynorphin A ...
E. Marrón Fernández de Velasco, E. Marrón Fernández de Velasco, Gemma Arsequell, Raquel E. Rodríguez, Raquel E. Rodríguez, Gregorio Valencia, Veronica Gonzalez-Nunez   +6 more
openaire   +4 more sources

Dynorphin and the pathophysiology of drug addiction [PDF]

Pharmacology & Therapeutics, 2007
Drug addiction is a chronic relapsing disease in which drug administration becomes the primary stimulus that drives behavior regardless of the adverse consequence that may ensue. As drug use becomes more compulsive, motivation for natural rewards that normally drive behavior decreases. The discontinuation of drug use is associated with somatic signs of
Vladimir I. Chefer, Agustin Zapata, Toni S. Shippenberg   +2 more
openaire   +3 more sources

Modulation of feeding behavior and metabolism by dynorphin [PDF]

Scientific Reports, 2020
AbstractThe neuronal regulation of metabolic and behavioral responses to different diets and feeding regimens is an important research area. Herein, we investigated if the opioid peptide dynorphin modulates feeding behavior and metabolism. Mice lacking dynorphin peptides (KO) were exposed to either a normal diet (ND) or a high-fat diet (HFD) for a ...
Andreas Zimmer, Ildiko Racz, Aishwarya Ghule, Andras Bilkei-Gorzo, Este Leidmaa, Meike Sieburg, Meike Sieburg   +6 more
openaire   +4 more sources

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Baseer, N., Furuta, T., Kaneko, T., Polgar, Erika, Todd, A., Watanabe, M.   +5 more
core   +1 more source