Results 21 to 30 of about 5,930 (239)

Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward

Addiction Neuroscience, 2022
Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR).
Antony D. Abraham, Sanne M. Casello, Benjamin B. Land, Charles Chavkin   +3 more
doaj   +1 more source

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M., Gallagher, S. M., Unterwald, E. M., Van Bockstaele, E. J.   +3 more
core   +2 more sources

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity [PDF]

, 2009
Insulin-degrading enzyme (IDE) is an interesting pharmacological target for Alzheimer's disease (AD), since it hydrolyzes beta-amyloid, producing non-neurotoxic fragments.
Ciaccio C, Coletta M., Gioia M, Grasso G, MARASCO, DANIELA, Rizzarelli E, Ruvo M, Spoto G, Tundo GR   +8 more
core   +1 more source

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

Cell & Bioscience, 2020
Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao, Zhiheng Chen   +5 more
doaj   +1 more source

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source

Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. [PDF]

PLoS ONE, 2010
BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors and several peptides. The peptides are derived from four prepropeptide genes, PENK, PDYN, PNOC and POMC, encoding enkephalins, dynorphins ...
Görel Sundström, Susanne Dreborg, Dan Larhammar   +2 more
doaj   +1 more source

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Baseer, N., Furuta, T., Kaneko, T., Polgar, Erika, Todd, A., Watanabe, M.   +5 more
core   +1 more source

Peptide ligand recognition by G protein-coupled receptors [PDF]

, 2015
Introduction: This study was conducted to investigate the effects of thyme extract in drinking water on immune response of broiler chickens. Methods: A total of 245-day-old broiler chicks were purchased and 20 chicks were bled for determination maternal ...
Brian E. Krumm, Reinhard Grisshammer
core   +4 more sources

Contralateral inhibition of click- and chirp-evoked human compound action potentials [PDF]

, 2017
Cochlear outer hair cells (OHC) receive direct efferent feedback from the caudal auditory brainstem via the medial olivocochlear (MOC) bundle. This circuit provides the neural substrate for the MOC reflex, which inhibits cochlear amplifier gain and is ...
Cone, Barbara K, Lichtenhan, Jeffery T, Smith, Spencer B   +2 more
core   +2 more sources

Salvinorin A, a kappa-opioid receptor (KOP-r) agonist hallucinogen: Pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders

Frontiers in Pharmacology, 2015
Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the ...
Eduardo eButelman, Mary Jeanne eKreek
doaj   +1 more source