Results 41 to 50 of about 664,070 (248)

E-Learning Development Management with The Schoology Improving Geographic Learning Literation

Journal of Education Technology, 2021
Lack of development of instructional media reduces student interest in learning so that it affects student literacy in the learning process. The purpose of this research is to develop E-learning with schoology to improve literacy in geography learning in
Tengku Muhammad Sahudra, Alamsyah Taher, Isthifa Kemal   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Developing an approach for Learning Design Players

Journal of Interactive Media in Education, 2005
Commentary on: Chapter 19: The Edubox Learning Design Player. (Tattersall, Vogten & Hermans, 2005) Abstract: The EduBox system as described in Tattersall, Vogten and Hermans (2005) was developed at the Open University of the Netherlands in order first ...
Patrick McAndrew, Rob Nadolski, Alex Little   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A first exploration of an inductive analysis approach for detecting learning design patterns

Journal of Interactive Media in Education, 2005
Commentary on: Chapter 1: An Introduction to Learning Design. (Koper, 2005) Abstract: One way to develop effective online courses is the use of learning design patterns, since patterns capture successful solutions.
Francis Brouns, Rob Koper, Jocelyn Manderveld, Jan van Bruggen, Peter Sloep, Peter van Rosmalen, Colin Tattersall, Hubert Vogten   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Managing IMS Learning Design

Journal of Interactive Media in Education, 2005
Commentary on: Chapter 15: How to Integrate Learning Design into Existing Practice. (Janssen & Hermans, 2005) Abstract: Taking IMS Learning Design (LD) beyond the domain of researchers and programmers, this short paper looks at some of the challenges of
Wolfgang Greller
doaj   +1 more source

E-LEARNING: DEVELOPMENT VECTOR

Высшее образование в России, 2016
The article addresses a number of areas of e-learning development: using mobile devices, the massive open online courses, computer simulation, automation systems, professional activities, computer games, the concept of a SMART education system, knowledge management.
Alexandr V. Solovov, Anastasia A. Men'shikova   +1 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source