Results 61 to 70 of about 4,727,114 (289)

Academic staff development in the area of technology enhanced learning in the UK HEIs [PDF]

open access: yes, 2012
This paper reports on a study on staff development in the area of technology enhanced learning in UK Higher Education Institutions (HEIs) that took place in November 2011.
Almpanis, Timos
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Quality Assessment for E-learning: a Benchmarking Approach (Third edition) [PDF]

open access: yes, 2016
The primary purpose of this manual is to provide a set of benchmarks, quality criteria and notes for guidance against which e-learning programmes and their support systems may be judged.
Kear, Karen   +8 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

A High-Resolution Spatial and Time-Series Labeled Unmanned Aerial Vehicle Image Dataset for Middle-Season Rice

open access: yesISPRS International Journal of Geo-Information, 2020
The existing remote sensing image datasets target the identification of objects, features, or man-made targets but lack the ability to provide the date and spatial information for the same feature in the time-series images.
Dongbo Zhou   +3 more
doaj   +1 more source

Supporting Sustainable e-learning: A UK National Forum [PDF]

open access: yes, 2003
This article outlines the progress of a national Supporting Sustainable eLearning Forum, funded by the UK Learning and Teaching Support Network Generic Centre.
Littlejohn, Allison, Wiles, Kathy
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Developing quality e-learning sites

open access: yesASCILITE Publications, 2009
The e-learning interface design should be a core, integrated component of the overall design of on-line units. The interface design should be determined by how people learn and the tasks they need to perform. This should be driven by a pedagogical, not technological, approach which identifies learning outcomes (Guralnick, 2008).
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Development and validation of conflict management attitude questionnaire for medical students

open access: yesBMC Medical Education, 2022
Background Medical students should effectively manage conflicts in teamwork and communication with other team members. This study aimed to develop and validate a tool to evaluate attitude of medical students and physicians toward conflict management ...
Fatemeh Mohseni   +4 more
doaj   +1 more source

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