E-selectin in vascular pathophysiology [PDF]
Frontiers in ImmunologySelectins are a group of Ca2+-dependent, transmembrane type I glycoproteins which attract cell adhesion and migration. E-selectin is exclusively expressed in endothelial cells, and its expression is strongly enhanced upon activation by pro-inflammatory ...
Jinjin Zhang +9 more
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Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study [PDF]
Brain Sciences, 2023 Background and Purpose: Little is known about the effect of soluble adhesion molecules on malignant brain edema (MBE) after endovascular thrombectomy (EVT).
Feng Zhou +7 more
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Low-dose photodynamic therapy promotes vascular E-selectin expression in chest malignancies, improving immune infiltration and tumor control [PDF]
Journal for ImmunoTherapy of CancerBackground Chest malignancies such as non-small cell lung cancer (NSCLC) or pleural mesothelioma (PM) have an ominous prognosis. Photodynamic therapy (PDT) of NSCLC and PM improves patient survival, but the precise underlying mechanism remains unknown ...
Sabina Berezowska +19 more
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PSGL-1 decorated with sialyl Lewisa/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement [PDF]
Scientific ReportsDissemination of multiple myeloma into the bone marrow proceeds through sequential steps mediated by a variety of adhesion molecules and chemokines that eventually results in the extravasation of malignant plasma cells into this protective niche ...
Michael O’Dwyer +4 more
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E-Selectin S128R Polymorphism Leads to Severe Asthma
Iranian Journal of Allergy, Asthma and Immunology, 2007 The E-selectin mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of asthma. It has been suggested that an S/R (Serine128Arginine) polymorphism of E-selectin alters ligand binding ...
Ebrahim Nadi +6 more
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Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
Angelo Zinellu, Arduino A. Mangoni
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Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells. [PDF]
PLoS ONE, 2012 Hematogenous metastasis involves the adhesion of circulating tumor cells to vascular endothelium of the secondary site. We hypothesized that breast cancer cell adhesion is mediated by interaction of endothelial E-selectin with its glycoprotein counter ...
Venktesh S Shirure +2 more
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CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. [PDF]
PLoS ONE, 2008 BACKGROUND: Endothelial E-selectin has been shown to play a pivotal role in mediating cell-cell interactions between breast cancer cells and endothelial monolayers during tumor cell metastasis.
Ke Zen +7 more
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Expression of E–Selectin and E–Selectin Ligands in Human Liver Inflammation [PDF]
Hepatology, 1996 Lymphocyte recruitment to tissue is regulated by homing molecules expressed on subsets of leukocytes that bind to endothelial adhesion molecules termed addressins in target tissues. The addressins and homing molecules involved in recruiting lymphocytes to inflamed human liver are not known.
D H, Adams +4 more
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Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow. [PDF]
PLoS ONE, 2013 Hematogenous metastasis accounts for the majority of cancer-related deaths, yet the mechanism remains unclear. Circulating tumor cells (CTCs) in blood may employ different pathways to cross blood endothelial barrier and establish a metastatic niche ...
Gunjan Gakhar +13 more
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