Results 171 to 180 of about 52,137 (255)

Integrated Immune, Epithelial and Lipid Pathways in NSAID‐Exacerbated Respiratory Disease

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT NSAID‐exacerbated respiratory disease (N‐ERD) is a chronic inflammatory disorder characterized by asthma, chronic rhinosinusitis with nasal polyps and respiratory reactions to cyclooxygenase‐1 inhibiting nonsteroidal anti‐inflammatory drugs (NSAID).
Piotr Szatkowski, Lucyna Mastalerz
wiley   +1 more source

E-selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor-prognosis signature in colorectal cancer. [PDF]

Mol Oncol
Cotton S, Ferreira D, Relvas-Santos M, Brandão A, Afonso LP, Miranda A, Ferreira E, Santos B, Gonçalves M, Lopes P, Santos LL, Silva AMN, Ferreira JA.   +12 more
europepmc   +1 more source

The Immuno‐Cardiovascular Storm of Pre‐Eclampsia: Cytokine‐Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Placental ischemia in pre‐eclampsia initiates cytokine‐driven endothelial dysfunction, angiogenic imbalance, oxidative stress, and thromboinflammation. Elevated TNF‐α, IL‐6, IL‐17, sFlt‐1, and complement activation promote vasoconstriction, thrombosis, and cardiovascular instability.
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy? [PDF]

Blood Rev
Uy GL, DeAngelo DJ, Lozier JN, Fisher DM, Jonas BA, Magnani JL, Becker PS, Lazarus HM, Winkler IG.   +8 more
europepmc   +1 more source

Thromboinflammatory biomarkers in obstetric pathophysiology: Predictive insights into placental insufficiency and feto‐maternal adverse outcomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL. [PDF]

Leukemia
Calvo J, Naguibneva I, Kypraios A, Gilain F, Uzan B, Gaillard B, Bellenger L, Renou L, Antoniewski C, Lapillonne H, Petit A, Ballerini P, Mancini SJ, Marchand T, Peyron JF, Pflumio F.   +15 more
europepmc   +1 more source

Vector‐based comparison as a novel framework for assessing multi‐endpoint clinical trials: Applications to actual data

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Multi‐endpoint clinical trials face long‐standing statistical challenges. Vector‐based comparison (VBC) decomposes endpoints into orthogonal components. Applied to five clinical trials, it reduced confidence‐interval widths by about 50%, indicating higher statistical power, without altering the clinical meaning of endpoints.
Maria Kokkali, Vangelis D. Karalis
wiley   +1 more source

Depletion of β1,6-N-acetylglucosaminyltransferase reduces E-selectin binding capacity and migratory potential of human gastrointestinal adenocarcinoma cells. [PDF]

Neoplasia
Staffeldt L, Maar H, Beimdiek J, Chambers S, Riecken K, von Itzstein M, Buettner FFR, Everest-Dass A, Lange T.   +8 more
europepmc   +1 more source

Pulsed Electric Field Processing Enhances the Endothelial Bioefficacy of Red Beet (Beta vulgaris L.) Extracts by Restoring Endothelial Nitric Oxide Synthase–Nitric Oxide Signaling in High‐Fat Diet Rats

eFood, Volume 7, Issue 4, August 2026.
Pulsed electric field (PEF) processing qualitatively reshapes the phytochemical profile of red beet extracts, resulting in enhanced endothelial bioefficacy. Compared with conventional extraction, PEF‐treated extracts more effectively restore nitric oxide signaling, suppress endothelial inflammation, and normalize vascular structure in high‐fat diet ...
Eunju Jang, Tae‐Baek Lee, Lisa Tonini, Soobin Choi, YoonA Jeon, Taehyun Kim, Taeyoung Kang, Hyuk‐Joon Choi, Changhwan Ahn   +8 more
wiley   +1 more source

Vascular E-selectin Expression Recognized by the U12-12 Monoclonal Antibody as a Predictive Marker for Steroid Resistance in Immune Checkpoint Inhibitor-related Colitis. [PDF]

J Histochem Cytochem
Nakashima K, Nagaya T, Iwaya M, Hiramatsu K, Uehara T, Nakamoto Y, Ishizuka T, Kobayashi M.   +7 more
europepmc   +1 more source