Results 241 to 250 of about 78,400 (265)

Plasma Soluble E-Selectin in Necrotising Enterocolitis

European Journal of Pediatric Surgery, 2008
E-selectin is an important mediator of leukocyte-endothelial adhesion. It is expressed on activated endothelium, and shed into the circulation in its soluble form. In babies with necrotising enterocolitis (NEC), increased intestinal expression of E-selectin has been associated with multiple organ failure and an adverse outcome.
Khoo, A.K., Hall, N.J., Alexander, N., Evennett, N.J., Pierro, A., Eaton, S.   +5 more
openaire   +3 more sources

A Ligand Binding Assay for E-Selectin

Analytical Biochemistry, 1994
We describe here a cell-free ligand binding assay for E-selectin. The assay involves immobilizing soluble E-selection onto microtiter plates and incubating with 125I-labeled carcinoembryonic antigen (CEA) which carries the tetrasaccharide sialyl Lewis x (sLex). The bound CEA is eluted by ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N',-tetraacetic
M, Anostario, S H, Li, K S, Huang
openaire   +2 more sources

Characterization of Murine E-Selectin Expression in Vitro Using Novel Anti-mouse E-Selectin Monoclonal Antibodies

Biochemical and Biophysical Research Communications, 1993
A recombinant phage containing the structural exons for mouse E-selectin has been isolated and characterized. Utilizing PCR techniques the lectin and egf domains were fused to form an artificial cDNA for expression in eukaryotic cells. Transient expression in COS cells demonstrated the lectin and egf domains were sufficient to mediate the binding of ...
C R, Norton, J M, Rumberger, D K, Burns, B A, Wolitzky   +3 more
openaire   +2 more sources

Distinct Phenotype of E-Selectin–Deficient Mice

Circulation Research, 1996
Leukocyte capture and rolling are mediated by calcium-dependent lectins expressed on most leukocytes (L-selectin) and the vascular endothelium (P- and E-selectin). To study the role of the selectins during inflammation, we have investigated leukocyte rolling in venules of tumor necrosis factor-α (TNF-α)–treated mouse cremaster muscles in wild-type mice
E J, Kunkel, K, Ley
openaire   +2 more sources

Alternatively processed human E-selectin transcripts linked to chronic expression of E-selectin in vivo.

The Journal of Immunology, 1994
Abstract E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1), is transiently expressed on endothelial cells in response to inflammatory cytokines such as IL-1 and TNF-alpha and mediates adhesion of leukocytes. The genomic structure of E-selectin is highly conserved and includes multiple polyadenylation signals ...
W, Chu, D H, Presky, R A, Swerlick, D K, Burns   +3 more
openaire   +2 more sources

Potential Significance of Circulating E-Selectin

Circulation, 1997
In the accompanying article, Belch and colleagues1 propose a model in which baseline levels of serum E-selectin (CD62E) are predictive of restenosis after percutaneous transluminal angioplasty in patients with peripheral arterial occlusive disease. Their data revealed significantly higher baseline serum E-selectin levels in patients who restenosed ...
openaire   +2 more sources

Kinetics of E-Selectin Expression in Surgical Flaps

Plastic & Reconstructive Surgery, 1997
During the ischemia/reperfusion phenomenon, adhesion molecules seem to play a critical role in the recruitment of neutrophils to sites of eventual tissue injury. E-selectin is an endothelium-derived molecule that mediates adhesion of neutrophils to activated endothelial cells.
C, Wang, C L, Kerrigan, M A, Stotland
openaire   +2 more sources

E-Selectin Gets HSCs Buzzing.

Science Translational Medicine, 2012
E-selectin inhibition may protect HSCs from chemo- and radiotherapy.
openaire   +1 more source

E-Selectin mediates pathogenic effects of antiphospholipid antibodies

Journal of Thrombosis and Haemostasis, 2003
Antiphospholipid (aPL) antibodies, detected in patients with antiphospholipid syndrome (APS) are associated with thrombosis, pregnancy loss and thrombocytopenia. Studies have shown that aPL are thrombogenic in vivo, but the mechanism(s) involved are not completely understood.
R G, Espinola, X, Liu, M, Colden-Stanfield, J, Hall, E N, Harris, S S, Pierangeli   +5 more
openaire   +2 more sources

E-Selectin, Internalization and Release

1993
E-selectin also designated ELAM-1/LECAM2 (1) is a 115kD membrane glycoprotein (2) which is induced on human endothelial cells by TNF, IL-1 and bacterial LPS (2–5). E-selectin is engaged in the adherence of neutrophil granulocytes, a subpopulation of monocytes and T-cells (2,6–9).
W. A. Buurman, E. J. U. von Asmuth, J. F. M. Leeuwenberg   +2 more
openaire   +1 more source