Results 31 to 40 of about 78,400 (265)

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

BMC Cancer, 2018
Background The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis.
Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira   +9 more
doaj   +1 more source

Characterization of equine E‐selectin

Immunology, 2001
SummaryExpression of E‐selectin on activated endothelium is a critical initial step that leads to extravasation of leucocytes during inflammation, yet E‐selectin is largely uncharacterized in several animal species including the horse. We have sequenced and compared E‐selectin genes derived from activated cultures of purified equine (horse), cervid ...
J F, Hedges, C D, Demaula, B D, Moore, B E, McLaughlin, S I, Simon, N J, MacLachlan   +5 more
openaire   +3 more sources

E-selectin ligand complexes adopt an extended high-affinity conformation [PDF]

, 2015
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewis(x) (sLe(x)).
Binder, Florian P. C., Ernst, Beat, Jakob, Roman P., Maier, Timm, Preston, Roland C., Sager, Christoph P.   +5 more
core   +2 more sources

Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage

Brazilian Journal of Medical and Biological Research, 2005
The goal of the present study was to determine concentrations of E-selectin in both cerebrospinal fluid (CSF) and serum of patients with aneurysmal subarachnoid hemorrhage (SAH) and to evaluate the correlation between the clinical parameters and E ...
T. Tanriverdi, G.Z. Sanus, M.O. Ulu, E. Tureci, H. Uzun, S. Aydin, M.Y. Kaynar   +6 more
doaj   +1 more source

E-selectin mediated adhesion and migration of endothelial colony forming cells is enhanced by SDF-1α/CXCR4. [PDF]

PLoS ONE, 2013
OBJECTIVE: Endothelial-colony forming cells (ECFCs) can be readily expanded from human umbilical cord blood and can facilitate repair of endothelial injury.
Jie Sun, Yuhua Li, Gina M Graziani, Lionel Filion, David S Allan   +4 more
doaj   +1 more source

Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation [PDF]

Inflammation, 1994
E-selectin is an inducible endothelial adhesion molecule that binds neutrophils. E-selectin mRNA is not constitutively detectable in the lungs of rats. Intratracheal injection of LPS induces pulmonary E-selectin mRNA expression at 2-4 h. Intratracheal injection of LPS followed at 2 and 4 h by intravenous injection of mouse F(ab')2 or F(ab') anti-E ...
Collins, Tucker, Yi, Eunhee S., Guo, Kaizhi, Williams, James H., Steininger, Christina N., Welply, Joseph K., Keene, Jeffery L., Schmuke, Jon J., Ulich, Thomas R., Howard, Susan C., Remick, Daniel G., Yin, Songmei   +11 more
openaire   +3 more sources

Targeting E-selectin to Tackle Cancer Using Uproleselan [PDF]

Cancers, 2021
E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role is to facilitate leukocyte cell trafficking by recognizing ligand surface proteins. E-selectin gained a new role since it was demonstrated to be involved in cancer cell trafficking, stem-like properties and therapy resistance.
Barbara Muz, Anas Abdelghafer, Matea Markovic, Jessica Yavner, Anupama Melam, Noha Nabil Salama, Abdel Kareem Azab   +6 more
openaire   +3 more sources

Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation [PDF]

, 2003
Introduction and methods: The reaction of superoxide anions and NO not only results in a decreased availability of NO, but also leads to the formation of peroxynitrite, the role of which in the cardiovascular system is still discussed controversially. In
Gloe, Torsten, Keller, Matthias, Klauss, Volker, Krötz, Florian, Pohl, Ulrich, Schiele, Thomas M., Sohn, Hae-Young, Theisen, Karl, Zahler, Stefan   +8 more
core   +1 more source

Soluble P- and E-selectin levels as determinants of vaso-occlusive crises among sickle cell anemia patients in a tertiary hospital Northwestern Nigeria

Iraqi Journal of Hematology, 2020
BACKGROUND: Vascular E- and P-selectins play important roles in sickle cell anemia (SCA), vaso-occlusive crises (VOC); however, the extent to which they determine VOC has not been studied.
Sani Awwalu, Abdulaziz Hassan, Aisha Indo Mamman, Abdul Wahab Alhassan, Ismaila Nda Ibrahim, Ibrahim Usman Kusfa, Aliyu Dahiru Waziri   +6 more
doaj   +1 more source

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources