Results 51 to 60 of about 78,400 (265)

E-selectin receptors on human leukocytes

Blood, 2008
Selectins on activated vascular endothelium mediate inflammation by binding to complementary carbohydrates on circulating neutrophils. The human neutrophil receptor for E-selectin has not been established. We report here that sialylated glycosphingolipids with 5 N-acetyllactosamine (LacNAc, Galβ1-4GlcNAcβ1-3) repeats and 2 to 3 fucose residues are ...
Leonardo, Nimrichter, Monica M, Burdick, Kazuhiro, Aoki, Wouter, Laroy, Mark A, Fierro, Sherry A, Hudson, Christopher E, Von Seggern, Robert J, Cotter, Bruce S, Bochner, Michael, Tiemeyer, Konstantinos, Konstantopoulos, Ronald L, Schnaar   +11 more
openaire   +3 more sources

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Implications of the E-selectin S128R mutation for drug discovery [PDF]

, 2017
The C-type lectin E-selectin mediates the rolling of circulating leukocytes on vascular endothelial cells during the inflammatory process. In numerous studies, the S128R mutation of the E-selectin was associated with cardiovascular and autoimmune ...
Binder, Florian P C., Ernst, Beat, Magnani, John L., Moes, Suzette, Preston, Roland C., Rabbani, Said   +5 more
core  

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, EarlyView.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source

E-Selectin and SDF-1 regulate metastatic trafficking of breast cancer cells within the bone

Molecular & Cellular Oncology, 2017
E-selectin is a key mediator of breast cancer cell (BCC) metastatic entry into the bone and stromal-derived factor 1 (SDF-1) is a critical molecular anchor for BCCs within discrete pro-dormancy bone marrow (BM) niches.
Trevor T. Price, Dorothy A. Sipkins
doaj   +1 more source

Elevated cystatin-C concentration is associated with progression to prediabetes: the Western New York Study [PDF]

, 2007
OBJECTIVE – We conducted a nested case-control investigation to examine if elevated baseline concentrations of cystatin-C predicted progression from normoglycaemia to prediabetes over 6 years of follow-up from the Western New York Health Study. RESEARCH
Dmochowski, Jacek, Donahue, Richard P., Rafalson, Lisa B., Rejman, Karol, Stranges, Saverio, Trevisan, Maurizio   +5 more
core   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Mediators of Inflammation, 2014
Introduction. The acute coronary syndrome (ACS) is a complex disease where genetic and environmental factors are involved. E-selectin gene is a candidate for ACS progression due to its contribution in the inflammatory process and endothelial function ...
Elena Sandoval-Pinto, Jorge Ramon Padilla-Gutiérrez, Emmanuel Valdes-Alvarado, Ilian Janet García-González, Angelica Valdez-Haro, Jose Francisco Muñoz-Valle, Hector Enrique Flores-Salinas, Fernando Rivas, Yeminia Valle   +8 more
doaj   +1 more source

Arterial stiffness and endothelial inflammation in prediabetes and newly diagnosed diabetes patients

Archives of Endocrinology and Metabolism, 2015
ObjectiveThere is a growing body of data supporting the association between diabetes and microcirculatory disfunction. We aimed to study e-selectin levels, and their associations with serum markers of inflammation and arterial stiffness in prediabetes ...
Mustafa Çakar, Şevket Balta, Hakan Şarlak, Muharrem Akhan, Sait Demirkol, Murat Karaman, Seyit Ahmet Ay, Ömer Kurt, Tuncer Çayci, Satılmış İnal, Şeref Demirbaş   +10 more
doaj   +1 more source

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways [PDF]

, 2014
The terpenoid 17-O-acetylacuminolide (AA) was shown to inhibit the production of several inflammatory mediators. However, the mechanisms by which this compound elicited its anti-inflammatory activity remain to be elucidated.
Achoui, Mouna, Haegeman, Guy, Heyninck, Karen, Looi, Chung Yeng, Mustafa, Ali Mohd, Mustafa, Mohd Rais   +5 more
core   +1 more source