Results 1 to 10 of about 11,522 (197)
Pathogens, 2022 Intravenous (IV) administration of antiviral monoclonal antibodies (mAbs) can be challenging, particularly during an ongoing epidemic, due to the considerable resources required for performing infusions.
Erin Kuang +17 more
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Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1 [PDF]
Communications BiologySudan ebolavirus (SUDV), like Ebola ebolavirus (EBOV), poses a significant threat to global health and security due to its high lethality. However, unlike EBOV, there are no approved vaccines or treatments for SUDV, and its structural interaction with ...
Fan Bu +5 more
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Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. [PDF]
PLoS Pathogens, 2010 Ebolavirus (EBOV) is an enveloped, single-stranded, negative-sense RNA virus that causes severe hemorrhagic fever with mortality rates of up to 90% in humans and nonhuman primates.
Asuka Nanbo +7 more
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Frontiers in Immunology, 2022 Monoclonal antibodies (mAbs) have proven effective for the treatment of ebolavirus infection in humans, with two mAb-based drugs Inmazeb™ and Ebanga™ receiving FDA approval in 2020.
Charles D. Murin +5 more
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Ebolaviruses: New roles for old proteins. [PDF]
PLoS Neglected Tropical Diseases, 2018 In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity.
Diego Cantoni, Jeremy S Rossman
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Revista Ciencias Biomédicas, 2020 La entidad conocida como ébola, recibe esa denominación por el nombre del río más cercano al distrito africano, donde se presentaron los primeros casos del brote en la década de los setenta del siglo XX (1).
Comité Editorial
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Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity
Virulence, 2021 Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%.
Satoko Yamaoka, Hideki Ebihara
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PLoS Neglected Tropical Diseases, 2022 Although multiple antigenically distinct ebolavirus species can cause human disease, previous serosurveys focused on only Zaire ebolavirus (EBOV). Thus, the extent of reactivity or exposure to other ebolaviruses, and which sociodemographic factors are ...
Kelly C L Shaffer +18 more
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One-Step Reverse-Transcription FRET-PCR for Differential Detection of Five Ebolavirus Species. [PDF]
PLoS ONE, 2015 Ebola is an emerging infectious disease caused by a deadly virus belonging to the family Filoviridae, genus Ebolavirus. Based on their geographical distribution, Ebolavirus has been classified into total five species so far, mainly Zaire, Sudan, Taï ...
Guangwu Lu +6 more
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One Health Outlook, 2021 Early detection of Ebola virus spillover into wildlife is crucial for rapid response. We developed and validated a portable, cold-chain independent Ebola virus RT-qPCR assay.
Dania M. Figueroa +14 more
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