Results 101 to 110 of about 12,455 (266)
Development and Structural Analysis of Antibody Therapeutics for Filoviruses
Pathogens, 2022 The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts.
Xiaoying Yu, Erica Ollmann Saphire
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Angewandte Chemie, Volume 136, Issue 50, December 9, 2024.In dieser Studie wurden durch Elektrospinning photoaktive Membranen aus hydrophobem PCL und hydrophilem PAN hergestellt, in die entweder ein hydrophober oder hydrophiler Photosensibilisator eingebettet wurde. Mit Hilfe der Fluoreszenzlebensdauer‐Mikroskopie konnten photoangeregte „aktive Zentren“ innerhalb der Membranen identifiziert werden und damit ...
Fabian Terlau +2 more
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Structural Basis for Differential Neutralization of Ebolaviruses
Viruses, 2012 There are five antigenically distinct ebolaviruses that cause hemorrhagic fever in humans or non-human primates (Ebola virus, Sudan virus, Reston virus, Taï Forest virus, and Bundibugyo virus).
John M. Dye +11 more
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Taï Forest Virus Does Not Cause Lethal Disease in Ferrets
Microorganisms, 2021 Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates.
Zachary Schiffman +8 more
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Regioselective Deacetylation in Nucleosides and Derivatives
ChemBioChem, Volume 25, Issue 23, December 2, 2024.Selective deprotection of the acetyl group(s) in acetylated nucleosides demonstrates practical significance in synthetic processes. It simplifies the preparation of partially or differentially substituted nucleoside intermediates. In this mini‐review, we summarized and evaluated recent approaches for regioselective deacetylation in acetylated ...
Charis Grabbe, Li Cai
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Testing New Hypotheses Regarding Ebolavirus Reservoirs
Viruses, 2016 Despite a relatively long search for the origin of ebolaviruses, their reservoirs remain elusive. Researchers might have to consider testing alternative hypotheses about how these viruses persist and emerge to advance ebolavirus research.
Siv Aina Jensen Leendertz
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Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease. [PDF]
, 2018 Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood.
Bernbaum, John G. +7 more
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Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39
British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier +4 more
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Predictive and comparative analysis of Ebolavirus proteins [PDF]
Cell Cycle, 2015 Ebolavirus is the pathogen for Ebola Hemorrhagic Fever (EHF). This disease exhibits a high fatality rate and has recently reached a historically epidemic proportion in West Africa. Out of the 5 known Ebolavirus species, only Reston ebolavirus has lost human pathogenicity, while retaining the ability to cause EHF in long-tailed macaque.
Nick V. Grishin, Qian Cong, Jimin Pei
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Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors
mAbs, 2020 Ebola virus (EBOV) can cause severe hemorrhagic fever in humans, and no approved treatment is currently available. Although several antibodies have achieved good protection in animal models, the potential emerging isolates of ebolavirus and the unknown ...
Pengfei Fan +12 more
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