Results 101 to 110 of about 13,687 (277)

Fruit–frugivore dependencies are important in Ebolavirus outbreaks in Sub-Saharan Africa

Ecography
Ebolaviruses have the ability to infect a wide variety of species, with many African mammals potentially serving either as primary reservoirs or secondary amplifying hosts.
Mekala Sundaram, Mireya Dorado, B. Akaribo, Antoine Filion, Barbara A. Han, N. Gottdenker, J. P. Schmidt, J. M. Drake, Patrick R Stephens   +8 more
semanticscholar   +1 more source

First laboratory confirmation and sequencing of Zaire ebolavirus in Uganda following two independent introductions of cases from the 10th Ebola Outbreak in the Democratic Republic of the Congo, June 2019

PLoS Neglected Tropical Diseases, 2022
Uganda established a domestic Viral Hemorrhagic Fever (VHF) testing capacity in 2010 in response to the increasing occurrence of filovirus outbreaks.
L. Nyakarahuka, S. Mulei, S. Whitmer, Kyondo Jackson, A. Tumusiime, A. Schuh, J. Baluku, Allison Joyce, F. Ocom, J. Tusiime, J. Montgomery, S. Balinandi, J. Lutwama, J. Klena, T. Shoemaker   +14 more
semanticscholar   +1 more source

Assembly and Budding of Ebolavirus

PLoS Pathogens, 2006
Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must reproduce its various components and assemble them in cells in order to reproduce infectious virions and perpetuate itself. To generate infectious Ebolavirus, a viral genome-protein complex called the nucleocapsid (NC) must be produced and transported to the cell ...
Takeshi Noda, Hideki Ebihara, Yukiko Muramoto, Ken Fujii, Ayato Takada, Hiroshi Sagara, Jin Hyun Kim, Hiroshi Kida, Heinz Feldmann, Yoshihiro Kawaoka   +9 more
openaire   +4 more sources

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor

MedComm, Volume 6, Issue 9, September 2025.
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang, Huiqiang Wang, Shuo Wu, Ge Yang, Haiyan Yan, Lijun Qiao, Xingqiong Li, Mengyuan Wu, Jiandong Jiang, Yuhuan Li   +9 more
wiley   +1 more source

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]

, 2015
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Agnarsson, Allison, Almeida, Amman, Amman, Baker, Biesold, Bolger, Carette, Carroll, Carstea, Chandran, Cui, Côté, Daugherty, Deffieu, Delport, Demogines, Demogines, Drexler, Ebihara, Feldmann, Ge, Gire, Grabherr, He, Herbert, Hueffer, Jahrling, Jangra, Jayme, Jones, Kaelber, Kamins, Katzourakis, Krishnan, Kugelman, Kuhn, Kühl, Lee, Leroy, Li, Mali, Maruyama, Meyerson, Miller, Miller, Miller-Butterworth, Murrell, Negredo, Ng, Olival, Park, Parker, Paweska, Peel, Pond, Radoshitzky, Radoshitzky, Raj, Ren, Robertson, Ross, Runz, Ruxton, Sheahan, Swenson, Swenson, Takada, Taylor, Taylor, Taylor, Tong, Towner, Vanier, Volchkov, Wahl-Jensen, Wong, Yang   +78 more
core   +2 more sources

Immunogenicity and safety of ebolavirus vaccines in healthy adults: a systematic review and meta-analysis of randomized controlled trials

Expert Review of Vaccines, 2023
Background This review aimed to systematically evaluate the immunogenicity and safety of the candidate Ebola virus vaccine (EVV). Methods We searched five databases for randomized controlled trials (RCTs) evaluating the effects of EVV on healthy adults ...
Juntao Yin, Liang Zhang, Chaoyang Wang, Changjiang Qin, Mingsan Miao   +4 more
semanticscholar   +1 more source

Ebolavirus and Marburgvirus: Insight the Filoviridae family [PDF]

Molecular Aspects of Medicine, 2008
Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule.
P. Ascenzi, A. Bocedi, J. Heptonstall, M. R. Capobianchi, A. Di Caro, E. Mastrangelo, M. Bolognesi, G. Ippolito   +7 more
openaire   +8 more sources

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

mBio, 2019
Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine ...
J. Maximilian Fels, Jennifer S. Spence, Robert H. Bortz, Zachary A. Bornholdt, Kartik Chandran   +4 more
doaj   +1 more source

Mapping the Potential Risk of Coronavirus Spillovers in a Global Hotspot

Global Change Biology, Volume 31, Issue 9, September 2025.
Bats host a vast array of viruses, including those behind SARS and COVID‐19. This study maps coronavirus spillover risk hotspots across South and Southeast Asia by combining horseshoe bat species distributions, forest fragmentation, and human population density.
R. Sedricke Lapuz, Ada Chornelia, Alice C. Hughes   +2 more
wiley   +1 more source

Ebola virus disease outbreak in Korea: use of a mathematical model and stochastic simulation to estimate risk [PDF]

Epidemiology and Health, 2019
OBJECTIVES According to the World Health Organization, there have been frequent reports of Ebola virus disease (EVD) since the 2014 EVD pandemic in West Africa. We aim to estimate the outbreak scale when an EVD infected person arrives in Korea.
Youngsuk Ko, Seok-Min Lee, Soyoung Kim, Moran Ki, Eunok Jung   +4 more
doaj   +1 more source