Results 21 to 30 of about 12,924 (266)
Serological evidence of ebolavirus infection in bats, China [PDF]
Virology Journal, 2012 Background The genus Ebolavirus of the family Filoviridae currently consists of five species. All species, with the exception of Reston ebolavirus, have been found in Africa and caused severe human diseases.
Yuan Junfa +5 more
doaj +4 more sources
Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies.
PLoS PathogensMonoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance.
Ariel S Wirchnianski +21 more
doaj +2 more sources
RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3′-leader region of genomic RNA [PDF]
Emerging Microbes and InfectionsEbola virus (EBOV) belongs to Filoviridae family possessing single-stranded negative-sense RNA genome, which is a serious threat to human health. Nowadays, no therapeutics have been proven to be successful in efficiently decreasing the mortality rate ...
Linjin Fan +14 more
openalex +2 more sources
bioRxivEbolavirus disease (EVD) is caused by multiple species of Ebolavirus. Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of EVD caused by Zaire ebolavirus (EBOV).
F. Donnellan +20 more
semanticscholar +2 more sources
PLoS Neglected Tropical Diseases, 2022 On the 8th of May, 2018, an outbreak of Ebola virus disease (EVD) was declared, originating in the Bikoro region of the Democratic Republic of the Congo (DRC) near the border with neighboring Republic of the Congo (ROC).
Stephanie N. Seifert +26 more
openalex +3 more sources
Assembly and Budding of Ebolavirus
PLoS Pathogens, 2006 Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must reproduce its various components and assemble them in cells in order to reproduce infectious virions and perpetuate itself. To generate infectious Ebolavirus, a viral genome-protein complex called the nucleocapsid (NC) must be produced and transported to the cell ...
Takeshi Noda +9 more
openalex +6 more sources
Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014 [PDF]
Viruses, 2014 In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa.
Jens H. Kuhn +43 more
doaj +6 more sources
Discovery of an Ebolavirus-Like Filovirus in Europe
PLoS Pathogens, 2011 Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease.
Anabel Negredo +15 more
openalex +10 more sources
Inclusion Bodies Are a Site of Ebolavirus Replication [PDF]
Journal of Virology, 2012 ABSTRACT Inclusion bodies are a characteristic feature of ebolavirus infections in cells. They contain large numbers of preformed nucleocapsids, but their biological significance has been debated, and they have been suggested to be aggregates of viral proteins without any further biological function.
Thomas Hoenen +9 more
openalex +3 more sources
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein [PDF]
Immunity, 2018 Ebolaviruses cause severe disease in humans, and identification of monoclonal antibodies (mAbs) that are effective against multiple ebolaviruses are important for therapeutics development. Here we describe a distinct class of broadly neutralizing human mAbs with protective capacity against three ebolaviruses infectious for humans: Ebola (EBOV), Sudan ...
Pavlo Gilchuk +31 more
openalex +7 more sources