Results 21 to 30 of about 12,943 (270)

Discovery of an Ebolavirus-Like Filovirus in Europe

PLoS Pathogens, 2011
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease.
Anabel Negredo, Gustavo Palacios, Sonia Vázquez‐Morón, Félix González, Hernán Dopazo, Francisca Molero, Javier Juste, Juan Quetglas, Nazir Savji, Maria de la Cruz Martínez, Jesus Enrique Herrera, Manuel Pizarro, Stephen Hutchison, Juan E. Echevarrı́a, W. Ian Lipkin, Antônio Tenório   +15 more
openalex   +10 more sources

Resurgence of Ebola in Uganda: Response Strategies, Lessons Learned, and Future Directions. [PDF]

Health Sci Rep
ABSTRACT Introduction The recent resurgence of Ebola virus disease (EVD), specifically the Sudan virus strain, in Uganda highlights the ongoing threat of emerging infectious diseases. This article aims to analyze the multifaceted factors contributing to this resurgence, evaluate the public health impact, and assess the effectiveness of response ...
Edward M, Muhigi S, Mundua J, Ally A.
europepmc   +2 more sources

Inclusion Bodies Are a Site of Ebolavirus Replication [PDF]

Journal of Virology, 2012
ABSTRACT Inclusion bodies are a characteristic feature of ebolavirus infections in cells. They contain large numbers of preformed nucleocapsids, but their biological significance has been debated, and they have been suggested to be aggregates of viral proteins without any further biological function.
Thomas Hoenen, Reed S. Shabman, Allison Groseth, Astrid Herwig, Michaela Weber, Gordian Schudt, Olga Dolnik, Christopher F. Basler, Stephan Becker, Heinz Feldmann   +9 more
openalex   +3 more sources

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein [PDF]

Immunity, 2018
Ebolaviruses cause severe disease in humans, and identification of monoclonal antibodies (mAbs) that are effective against multiple ebolaviruses are important for therapeutics development. Here we describe a distinct class of broadly neutralizing human mAbs with protective capacity against three ebolaviruses infectious for humans: Ebola (EBOV), Sudan ...
Pavlo Gilchuk, Natalia A. Kuzmina, Philipp A. Ilinykh, Kai Huang, Bronwyn M. Gunn, Aubrey L. Bryan, Edgar Davidson, Benjamin J. Doranz, Hannah L. Turner, Marnie L. Fusco, Matthew S. Bramble, Nicole A. Hoff, Elad Binshtein, Nurgun Kose, Andrew I. Flyak, Robin Flinko, Chiara Orlandi, Robert H. Carnahan, Erica H. Parrish, Alexander M. Sevy, Robin G. Bombardi, Prashant K. Singh, Patrick Mukadi, Jean Jacques Muyembe-Tamfum, Melanie D. Ohi, Erica Ollmann Saphire, George K. Lewis, Galit Alter, Andrew B. Ward, Anne W. Rimoin, Alexander Bukreyev, James E. Crowe   +31 more
openalex   +7 more sources

rVSV-ZEBOV vaccination in people with pre-existing immunity to Ebolavirus: an open-label safety and immunogenicity study in Guinean communities affected by Ebola virus disease (l'essai proches). [PDF]

BMC Med
Background Zaire Ebolavirus disease (EVD) outbreaks can be controlled using rVSV-ZEBOV vaccination and other public health measures. People in high-risk areas may have pre-existing antibodies from asymptomatic Ebolavirus exposure that might affect ...
Watson CH, Gsell PS, Hall Y, Camacho A, Riveros X, Enwere G, Vicari A, Nadlaou SD, Toure A, Sani IM, Diallo A, Kolie C, Duraffour S, Ifono K, Maomou A, Dore K, Djidonou HA, Bagayoko A, Damey PP, Camara MN, Diallo FB, Oumar FT, Toure K, Diaby ML, Sylla L, Conde D, Kaba IL, Tipton T, Eggo RM, Marks M, Roberts CH, Strecker T, Günther S, Keita S, Edmunds WJ, Carroll MW, Henao-Restrepo AM.   +36 more
europepmc   +3 more sources

Characterization of Ebolavirus regulatory genomic regions [PDF]

Virus Research, 2009
For filoviruses, such as Ebolavirus and the closely related Marburgvirus, transcriptional regulation is poorly understood. The open reading frames (ORFs) that encode the viral proteins are separated by regulatory regions composed of the 3' nontranslated region (NTR) of the upstream gene, highly conserved transcription stop and start signals, and the 5 ...
Gabriele Neumann, Shinji Watanabe, Yoshihiro Kawaoka   +2 more
openalex   +3 more sources

Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques [PDF]

American Journal of Pathology, 2023
David X. Liu, Bapi Pahar, Donna L. Perry, Huanbin Xu, Timothy K. Cooper, Louis Huzella, Randy Hart, Amanda M.W. Hischak, John G. Bernbaum, Marisa St. Claire, Russell Byrum, Richard S. Bennett, Travis K. Warren, Michael R. Holbrook, Lisa E. Hensley, Ian Crozier, Connie S. Schmaljohn   +16 more
openalex   +2 more sources

Ebolaviruscomparative genomics [PDF]

FEMS Microbiology Reviews, 2015
(Uploaded by Plazi for the Bat Literature Project) The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine the dynamics of this genome, we compare more than 100 currently available ebolavirus genomes to each other and to other viral genomes.
Qian Zhang, Qian Zhang, David W. Ussery, David W. Ussery, David W. Ussery, Gregory S. Buzard, Visanu Wanchai, Se-Ran Jun, Se-Ran Jun, Morten Nielsen, Thomas Trolle, Trudy M. Wassenaar, Michael R. Leuze, Intawat Nookaew, Juanjuan Chai, Miriam Land, Ole Lund, Edward C. Uberbacher, Thomas Pedersen, Thomas Pedersen   +19 more
openaire   +5 more sources

Ebolavirus’s Foibles [PDF]

Cell, 2017
Ebola virus disease poses a global health threat. Here, two studies by Wec et al. and Zhao et al. identified vulnerability in an internal fusion loop of an ebolavirus glycoprotein. Monoclonal antibodies elicited from immunization and isolated from a human survivor that recognized epitopes in this area neutralized all five ebolaviruses, guiding the ...
Seiya Yamayoshi, Yoshihiro Kawaoka, Yoshihiro Kawaoka   +2 more
openaire   +3 more sources

Natural History of Sudan ebolavirus to Support Medical Countermeasure Development [PDF]

Vaccines, 2022
Sudan ebolavirus (SUDV) is one of four members of the Ebolavirus genus known to cause Ebola Virus Disease (EVD) in humans, which is characterized by hemorrhagic fever and a high case fatality rate.
Caroline Carbonnelle, Marie Moroso, Delphine Pannetier, Sabine Godard, Stéphane Mély, Damien Thomas, Aurélie Duthey, Ophélie Jourjon, Orianne Lacroix, Béatrice Labrosse, Hervé Raoul, Karen L. Osman, Francisco J. Salguero, Yper Hall, Carol L. Sabourin, Michael Merchlinsky, James P. Long, Lindsay A. Parish, Daniel Wolfe   +18 more
openalex   +2 more sources