Results 21 to 30 of about 12,455 (266)

Risks Posed by Reston, the Forgotten Ebolavirus [PDF]

mSphere, 2016
Out of the five members of the Ebolavirus family, four cause lifethreatening disease, whereas the fifth, Reston virus (RESTV), is nonpathogenic in humans. The reasons for this discrepancy remain unclear. In this review, we analyze the currently available
Arran Hamlet, Carolyn B. Coyne, Diego Cantoni, Jeremy S. Rossman, Mark N. Wass, Martin Michaelis   +5 more
core   +8 more sources

Assembly and Budding of Ebolavirus

PLoS Pathogens, 2006
Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must reproduce its various components and assemble them in cells in order to reproduce infectious virions and perpetuate itself. To generate infectious Ebolavirus, a viral genome-protein complex called the nucleocapsid (NC) must be produced and transported to the cell ...
Takeshi Noda, Hideki Ebihara, Yukiko Muramoto, Ken Fujii, Ayato Takada, Hiroshi Sagara, Jinhyun Kim, Hiroshi Kida, Heinz Feldmann, Yoshihiro Kawaoka   +9 more
openalex   +6 more sources

Ebolavirus and Other Filoviruses [PDF]

FEMS Microbiology Reviews, 2007
(Uploaded by Plazi for the Bat Literature Project) Since Ebola fever emerged in Central Africa in 1976, a number of studies have been undertaken to investigate its natural history and to characterize its transmission from a hypothetical reservoir host(s) to humans.
Xavier Pourrut, Eric M. Leroy, Jean-Paul Gonzalez   +2 more
  +20 more sources

Discovery of an Ebolavirus-Like Filovirus in Europe

PLoS Pathogens, 2011
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease.
Anabel Negredo, Gustavo Palacios, Sonia Vázquez‐Morón, Félix González, Hernán Dopazo, Francisca Molero, Javier Juste, Juan Quetglas, Nazir Savji, Maria de la Cruz Martínez, Jesus Enrique Herrera, Manuel Pizarro, Stephen Hutchison, Juan E. Echevarrı́a, W. Ian Lipkin, Antônio Tenório   +15 more
openalex   +10 more sources

Inclusion Bodies Are a Site of Ebolavirus Replication [PDF]

Journal of Virology, 2012
ABSTRACT Inclusion bodies are a characteristic feature of ebolavirus infections in cells. They contain large numbers of preformed nucleocapsids, but their biological significance has been debated, and they have been suggested to be aggregates of viral proteins without any further biological function.
Thomas Hoenen, Reed S. Shabman, Allison Groseth, Astrid Herwig, Michaela Weber, Gordian Schudt, Olga Dolnik, Christopher F. Basler, Stephan Becker, Heinz Feldmann   +9 more
openalex   +3 more sources

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein [PDF]

Immunity, 2018
Ebolaviruses cause severe disease in humans, and identification of monoclonal antibodies (mAbs) that are effective against multiple ebolaviruses are important for therapeutics development. Here we describe a distinct class of broadly neutralizing human mAbs with protective capacity against three ebolaviruses infectious for humans: Ebola (EBOV), Sudan ...
Pavlo Gilchuk, Natalia A. Kuzmina, Philipp A. Ilinykh, Kai Huang, Bronwyn M. Gunn, Aubrey L. Bryan, Edgar Davidson, Benjamin J. Doranz, Hannah L. Turner, Marnie L. Fusco, Matthew S. Bramble, Nicole A. Hoff, Elad Binshtein, Nurgun Kose, Andrew I. Flyak, Robin Flinko, Chiara Orlandi, Robert H. Carnahan, Erica H. Parrish, Alexander M. Sevy, Robin G. Bombardi, Prashant K. Singh, Patrick Mukadi, Jean Jacques Muyembe-Tamfum, Melanie D. Ohi, Erica Ollmann Saphire, George K. Lewis, Galit Alter, Andrew B. Ward, Anne W. Rimoin, Alexander Bukreyev, James E. Crowe   +31 more
openalex   +7 more sources

Characterization of Ebolavirus regulatory genomic regions [PDF]

Virus Research, 2009
For filoviruses, such as Ebolavirus and the closely related Marburgvirus, transcriptional regulation is poorly understood. The open reading frames (ORFs) that encode the viral proteins are separated by regulatory regions composed of the 3' nontranslated region (NTR) of the upstream gene, highly conserved transcription stop and start signals, and the 5 ...
Gabriele Neumann, Shinji Watanabe, Yoshihiro Kawaoka   +2 more
openalex   +3 more sources

Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques [PDF]

American Journal of Pathology, 2023
David X. Liu, Bapi Pahar, Donna L. Perry, Huanbin Xu, Timothy K. Cooper, Louis Huzella, Randy Hart, Amanda M.W. Hischak, John G. Bernbaum, Marisa St. Claire, Russell Byrum, Richard S. Bennett, Travis K. Warren, Michael R. Holbrook, Lisa E. Hensley, Ian Crozier, Connie S. Schmaljohn   +16 more
openalex   +2 more sources

EbolavirusVP35 is a multifunctional virulence factor [PDF]

Virulence, 2010
Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synthesis.
Daisy W. Leung, Kathleen C. Prins, Christopher F. Basler, Gaya K. Amarasinghe   +3 more
openalex   +4 more sources

Evolution of viral pathogens follows a linear order [PDF]

Microbiology Spectrum, Vol. 10, No. 1, pp. e01655-21, 2022, 2022
Although lessons have been learned from previous severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) outbreaks, the rapid evolution of the viruses means that future outbreaks of a much larger scale are possible, as shown by the current coronavirus disease 2019 (COVID-19) outbreak.
arxiv   +1 more source