Results 31 to 40 of about 13,687 (277)

Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity

Virulence, 2021
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%.
Satoko Yamaoka, Hideki Ebihara
doaj   +1 more source

One-Step Reverse-Transcription FRET-PCR for Differential Detection of Five Ebolavirus Species. [PDF]

PLoS ONE, 2015
Ebola is an emerging infectious disease caused by a deadly virus belonging to the family Filoviridae, genus Ebolavirus. Based on their geographical distribution, Ebolavirus has been classified into total five species so far, mainly Zaire, Sudan, Taï ...
Guangwu Lu, Jilei Zhang, Chuntao Zhang, Xiaolu Li, Dawei Shi, Zhaopeng Yang, Chengming Wang   +6 more
doaj   +1 more source

Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry [PDF]

Journal of Virology, 2011
ABSTRACT With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and “cuevaviruses”) cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP 1,2 , to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion.
Sheli R, Radoshitzky, Kelly L, Warfield, Xiaoli, Chi, Lian, Dong, Krishna, Kota, Steven B, Bradfute, Jacqueline D, Gearhart, Cary, Retterer, Philip J, Kranzusch, John N, Misasi, Marc A, Hogenbirk, Victoria, Wahl-Jensen, Viktor E, Volchkov, James M, Cunningham, Peter B, Jahrling, M Javad, Aman, Sina, Bavari, Michael, Farzan, Jens H, Kuhn   +18 more
openaire   +2 more sources

Development and validation of portable, field-deployable Ebola virus point-of-encounter diagnostic assay for wildlife surveillance

One Health Outlook, 2021
Early detection of Ebola virus spillover into wildlife is crucial for rapid response. We developed and validated a portable, cold-chain independent Ebola virus RT-qPCR assay.
Dania M. Figueroa, Eeva Kuisma, M. Jeremiah Matson, Alain U. Ondzie, Trent Bushmaker, Stephanie N. Seifert, Francine Ntoumi, Beatriz Escudero-Pérez, César Muñoz-Fontela, Chris Walzer, Sarah H. Olson, Cynthia Goma-Nkoua, Jean-Vivien Mombouli, Robert J. Fischer, Vincent J. Munster   +14 more
doaj   +1 more source

Tracking ebolavirus genomic drift with a resequencing microarray.

PLoS ONE, 2022
Filoviruses are emerging pathogens that cause acute fever with high fatality rate and present a global public health threat. During the 2013-2016 Ebola virus outbreak, genome sequencing allowed the study of virus evolution, mutations affecting ...
Irina Tiper, Moussa Kourout, Bryan Lanning, Carolyn Fisher, Krishnamurthy Konduru, Anjan Purkayastha, Gerardo Kaplan, Robert Duncan   +7 more
doaj   +1 more source

Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness. [PDF]

Autophagy
Ebola virus disease (EVD) caused by Zaire Ebolavirus (EBOV) infection is a major threat to public health in Africa and even worldwide, due to its extremely high mortality rate. However, there are still no effective antiviral therapies that can completely
Huang H, Shi W, Yan H, Fan L, Lu J, Long Z, Li X, Li J, Wang J, Liu L, Qian J.   +10 more
europepmc   +2 more sources

Epidemiology of Ebolaviruses from an Etiological Perspective

Pathogens, 2023
Since the inception of the ebolavirus in 1976, 32 outbreaks have resulted in nearly 15,350 deaths in more than ten countries of the African continent. In the last decade, the largest (2013–2016) and second largest (2018–2020) ebolavirus outbreaks have ...
Sahil Jain, Svetlana Khaiboullina, Ekaterina Martynova, Sergey Morzunov, Manoj Baranwal   +4 more
doaj   +1 more source

The challenges of open data for future epidemic preparedness: The experience of the 2022 Ebolavirus outbreak in Uganda

Frontiers in Pharmacology, 2023
On 20 September 2022, the Ministry of Health in Uganda, together with the World Health Organization—Regional Office for Africa (WHO AFRO) confirmed an outbreak of EVD due to Sudan ebolavirus in Mubende District, after one fatal case was confirmed.
F. Branda, A. Mahal, A. Maruotti, Massimo Pierini, S. Mazzoli   +4 more
semanticscholar   +1 more source

Epitope-based peptide vaccine against Bombali Ebolavirus viral protein 40: An immunoinformatics combined with molecular docking studies

Informatics in Medicine Unlocked, 2021
Bombali Ebolavirus belongs to the RNA group of viruses which causes lethal hemorrhagic fever with a high mortality rate. Despite these facts, yet there is no approved vaccine have been developed for the eradication of Bombali Ebolavirus infections ...
Mujahed I. Mustafa, Shaza W. Shantier, Miyssa I. Abdelmageed, Abdelrafie M. Makhawi   +3 more
doaj   +1 more source

VP24-Karyopherin alpha binding affinities differ between Ebolavirus species, nfluencing interferon inhibition and VP24 stability [PDF]

, 2017
Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV) belong to the same genus but exhibit different virulence properties.
Alinger, Joshua B, Amarasinghe, Gaya K, Basler, Christopher F, Diederichs, Audrey, Edwards, Megan R, Leung, Daisy W, Schwarz, Toni M   +6 more
core   +2 more sources