Results 71 to 80 of about 11,522 (197)

Characterization of Ebolavirus regulatory genomic regions [PDF]

Virus Research, 2009
For filoviruses, such as Ebolavirus and the closely related Marburgvirus, transcriptional regulation is poorly understood. The open reading frames (ORFs) that encode the viral proteins are separated by regulatory regions composed of the 3' nontranslated region (NTR) of the upstream gene, highly conserved transcription stop and start signals, and the 5 ...
Gabriele, Neumann, Shinji, Watanabe, Yoshihiro, Kawaoka   +2 more
openaire   +2 more sources

Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two‐Sample Mendelian Randomization Study Based on European Ancestry

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Objective This study employed Mendelian randomization (MR) to investigate the causal relationships between 4907 circulating proteins and hyperlipidemia, with the aim of identifying potential drug targets. Methods Instrumental variables were derived from genome‐wide association study (GWAS) data on 4907 circulating proteins ...
Hui Cheng, Dayuan Zhong
wiley   +1 more source

Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domain [PDF]

, 2012
Background The genus Ebolavirus includes five distinct viruses. Four of these viruses cause hemorrhagic fever in humans. Currently there are no licensed vaccines for any of them; however, several vaccines are under development.
Wu Ou, Josie Delisle, Jerome Jacques, Joanna Shih, Graeme Price, Jens H Kuhn, Vivian Wang, Daniela Verthelyi, Gerardo Kaplan, Carolyn A Wilson   +9 more
core   +2 more sources

Assembly and Budding of Ebolavirus

PLoS Pathogens, 2006
Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must reproduce its various components and assemble them in cells in order to reproduce infectious virions and perpetuate itself. To generate infectious Ebolavirus, a viral genome-protein complex called the nucleocapsid (NC) must be produced and transported to the cell ...
Takeshi Noda, Hideki Ebihara, Yukiko Muramoto, Ken Fujii, Ayato Takada, Hiroshi Sagara, Jin Hyun Kim, Hiroshi Kida, Heinz Feldmann, Yoshihiro Kawaoka   +9 more
openaire   +4 more sources

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor

MedComm, Volume 6, Issue 9, September 2025.
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang, Huiqiang Wang, Shuo Wu, Ge Yang, Haiyan Yan, Lijun Qiao, Xingqiong Li, Mengyuan Wu, Jiandong Jiang, Yuhuan Li   +9 more
wiley   +1 more source

Introducing EbolaCheck: potential for point-of-need infectious disease diagnosis [PDF]

, 2015
The 2013–2015 Ebolavirus disease humanitarian crisis has spurred the development of laboratory-free, point-of-care nucleic acid testing solutions.
Christie A, Mather ST, Moreau M, Pasloske BL, Regules JA, Spengler JR, Sterghios Athanasios Moschos   +6 more
core   +1 more source

Ebolavirus and Marburgvirus: Insight the Filoviridae family [PDF]

Molecular Aspects of Medicine, 2008
Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule.
P. Ascenzi, A. Bocedi, J. Heptonstall, M. R. Capobianchi, A. Di Caro, E. Mastrangelo, M. Bolognesi, G. Ippolito   +7 more
openaire   +8 more sources

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

mBio, 2019
Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine ...
J. Maximilian Fels, Jennifer S. Spence, Robert H. Bortz, Zachary A. Bornholdt, Kartik Chandran   +4 more
doaj   +1 more source

Ebola virus disease outbreak in Korea: use of a mathematical model and stochastic simulation to estimate risk [PDF]

Epidemiology and Health, 2019
OBJECTIVES According to the World Health Organization, there have been frequent reports of Ebola virus disease (EVD) since the 2014 EVD pandemic in West Africa. We aim to estimate the outbreak scale when an EVD infected person arrives in Korea.
Youngsuk Ko, Seok-Min Lee, Soyoung Kim, Moran Ki, Eunok Jung   +4 more
doaj   +1 more source

Mapping the Potential Risk of Coronavirus Spillovers in a Global Hotspot

Global Change Biology, Volume 31, Issue 9, September 2025.
Bats host a vast array of viruses, including those behind SARS and COVID‐19. This study maps coronavirus spillover risk hotspots across South and Southeast Asia by combining horseshoe bat species distributions, forest fragmentation, and human population density.
R. Sedricke Lapuz, Ada Chornelia, Alice C. Hughes   +2 more
wiley   +1 more source