Results 91 to 100 of about 23,261 (287)
New cell wall-affecting antifungal antibiotics [PDF]
, 2013 Capítulo 9.Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections. Invasive fungal infections can be life-threatening.
Cortés, Juan Carlos G. +2 more
core +2 more sources
ACS Central Science, 2020 Echinocandins are the newest class of antifungal drugs in clinical use. These agents inhibit β-glucan synthase, which catalyzes the synthesis of β-glucan, an essential component of the fungal cell wall, and have a high clinical efficacy and low toxicity.
Qais Z. Jaber +5 more
semanticscholar +1 more source
Candida auris in Heart Transplant Donor: First Isolation in a Southern Italy Heart Transplant Center
Clinical Case Reports, Volume 14, Issue 1, January 2026.Timeline of infection control in a heart transplant from a donor colonized with Candida auris: from detection at retrieval to strict isolation, antifungal prophylaxis, negative follow‐up cultures, and successful prevention of transmission. ABSTRACT Candida auris is an emerging multidrug‐resistant fungal pathogen increasingly implicated in healthcare ...
Lorenzo Giovannico +6 more
wiley +1 more source
New Horizons in Antifungal Therapy
Journal of Fungi, 2016 Recent investigations have yielded both profound insights into the mechanisms required by pathogenic fungi for virulence within the human host, as well as novel potential targets for antifungal therapeutics.
Kaila M. Pianalto, J. Andrew Alspaugh
doaj +1 more source
Imidazolium‐Based Ionic Liquids as Antifungal and Antibiofilm Agents Against Candida tropicalis
ChemistrySelect, Volume 11, Issue 4, 28 January 2026.Candida sp. biofilms, particularly those formed on catheters, represent a major clinical challenge. This study evaluates ionic liquids using an experimental biofilm model, demonstrating significant antifungal activity and biofilm disruption, supporting their potential application as alternative strategies for device‐associated infection control ...
Giovanna de Jesus Agostinetto +4 more
wiley +1 more source
Echinocandin Resistance in Candida [PDF]
Clinical Infectious Diseases, 2015 Invasive fungal infections are an important infection concern for patients with underlying immunosuppression. Antifungal therapy is a critical component of patient care, but therapeutic choices are limited due to few drug classes. Antifungal resistance, especially among Candida species, aggravates the problem.
openaire +2 more sources
Journal of Fungi, 2021 Rezafungin is a novel echinocandin in Phase 3 development for prevention of invasive fungal disease caused by Candida spp., Aspergillus spp. and Pneumocystis jirovecii in blood and marrow transplantation patients.
Melanie T. Cushion, Alan Ashbaugh
doaj +1 more source
Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi [PDF]
, 2015 Genomics has revolutionized the research on fungal secondary metabolite (SM) biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific SM compound, the important first step is often to find the genes that
Cacho, Ralph A. +2 more
core +1 more source
Small Structures, Volume 7, Issue 1, January 2026.This work developed a PDC nanoplatform that orchestrated a multimodal synergistic therapy, combining active targeting, photothermal therapy, and iron nutrient deprivation. The antifungal, anti‐inflammatory efficacy and corneal repair ability of nanoplatform were demonstrated through both in vitro and in vivo evaluations.
Ruojiao Feng +13 more
wiley +1 more source
Comparison of echinocandin antifungals
Therapeutics and Clinical Risk Management, 2007 The incidence of invasive fungal infections, especially those due to Aspergillus spp. and Candida spp., continues to increase. Despite advances in medical practice, the associated mortality from these infections continues to be substantial. The echinocandin antifungals provide clinicians with another treatment option for serious fungal infections ...
Gregory, Eschenauer +2 more
openaire +3 more sources