Results 11 to 20 of about 23,261 (287)

FDA-Approved Antibacterials and Echinocandins

Antibiotics
Since 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA).
Othman Al Musaimi
doaj   +5 more sources

An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment

mBio, 2022
Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradients defined by
Joshua D. Kerkaert, François Le Mauff, Benjamin R. Wucher, Sarah R. Beattie, Elisa M. Vesely, Donald C. Sheppard, Carey D. Nadell, Robert A. Cramer   +7 more
doaj   +2 more sources

Functional redundancy in Echinocandin B in-cluster transcription factor ecdB of Emericella rugulosa NRRL 11440

Biotechnology Reports, 2018
Echinocandin B is a potent antifungal against the majority of fungal pathogens and its biosynthesis occurred by ecd and hty gene clusters in Emericella rugulosa NRRL 11440. We elucidated the functional necessity of in-clustered transcription factor; ecdB
Arvind Kumar, Varun Jaiswal, Vinay Kumar, Amitava Dey, Antresh Kumar   +4 more
doaj   +2 more sources

Critical Assessment of Cell Wall Integrity Factors Contributing to in vivo Echinocandin Tolerance and Resistance in Candida glabrata

Frontiers in Microbiology, 2021
Fungal infections are on the rise, and emergence of drug-resistant Candida strains refractory to treatment is particularly alarming. Resistance to azole class antifungals, which have been extensively used worldwide for several decades, is so high in ...
Rocio Garcia-Rubio, Rosa Y. Hernandez, Alissa Clear, Kelley R. Healey, Erika Shor, Erika Shor, David S. Perlin, David S. Perlin, David S. Perlin   +8 more
doaj   +2 more sources

A benchmark dataset for validating FKS1 mutations in Candida auris [PDF]

Microbiology Spectrum
Echinocandins are the recommended antifungal therapy for Candida auris infections in many countries. While echinocandin resistance remains uncommon, recent reports demonstrate an increase in such cases, with the potential for echinocandin-resistant C ...
Elizabeth Misas, Lindsay A. Parnell, Malavika Rajeev, Luisa F. López, Amanda Ribeiro dos Santos, Zachary B. Mudge, Lalitha Gade, Kaitlin Forsberg, Meghan Lyman, D. Joseph Sexton, Anastasia P. Litvintseva, Shawn R. Lockhart, Nancy A. Chow   +12 more
doaj   +2 more sources

Fungal echinocandin resistance [PDF]

F1000 Biology Reports, 2010
Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of β-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the Fks subunit of the target enzyme complex or a compensatory increase in the
Carol A. Munro
  +6 more sources

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

Journal of Fungi, 2020
Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods.
Maroun M. Sfeir, Cristina Jiménez-Ortigosa, Maria N. Gamaletsou, Audrey N. Schuetz, Rosemary Soave, Koen Van Besien, Catherine B. Small, David S. Perlin, Thomas J. Walsh   +8 more
doaj   +2 more sources

Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance. [PDF]

Nat Commun
Zhu Q, Van de Velde S, Wijnants S, Carolus H, Jacobs S, Sofras D, Vandecruys P, Van Goethem O, Feil R, Vergauwen R, Van Genechten W, Van den Ende W, Rybak JM, Himmelreich U, Lunn JE, Van Dijck P.   +15 more
europepmc   +3 more sources

Curcumin Epigenetically Represses Histone Acetylation of Echinocandin B Producing Emericella rugulosa

Physiologia, 2023
Echinocandin B is a natural product that possesses potent antifungal property against a wide array of fungi. This antifungal agent is produced by Emericella rugulosa. The biosynthetic genes of echinocandin B are physically organized in two gene clusters (
Vandana Kumari, Vinay Kumar, Manisha Kaushal, Antresh Kumar   +3 more
doaj   +1 more source

Whole genome sequencing analysis demonstrates therapy‐induced echinocandin resistance in Candida auris isolates

Mycoses (Berlin), 2023
Candida auris is an emerging, multidrug‐resistant yeast, causing outbreaks in healthcare facilities. Echinocandins are the antifungal drugs of choice to treat candidiasis, as they cause few side effects and resistance is rarely found.
Bram Spruijtenburg, Suhail Ahmad, M. Asadzadeh, W. Alfouzan, I. Al-Obaid, E. Mokaddas, Eelco F. J. Meijer, J. Meis, Theun de Groot   +8 more
semanticscholar   +1 more source