Results 51 to 60 of about 17,768 (255)
Marine DrugsNaturally occurring echinocandin B and FR901379 are potent antifungal lipopeptides featuring a cyclic hexapeptide nucleus and a fatty acid side chain.
Xuejian Jiang +5 more
doaj +1 more source
Epidemiology of Echinocandin Resistance in Candida [PDF]
Current Fungal Infection Reports, 2014 Echinocandins are the newest antifungal agents approved for use in treating Candida infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to Candida cell death. There is no intrinsic resistance to echinocandins among Candida species, and isolates from historic collections archived
Shawn R. Lockhart +2 more
openaire +3 more sources
Review on Current Status of Echinocandins Use [PDF]
Antibiotics, 2020 Fungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other ...
Martyna Mroczyńska +1 more
openaire +4 more sources
Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris
Emerging Microbes and InfectionsIntroduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations ...
Sufei Tian +8 more
doaj +1 more source
mBio, 2022 Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradients defined by
Joshua D. Kerkaert +7 more
doaj +1 more source
Resistance in Candida albicans: exploring the cell wall barrier by proteomics [PDF]
, 2015 The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients.
Angiolella, Letizia +2 more
core +1 more source
Review of the Novel Echinocandin Antifungal Rezafungin: Animal Studies and Clinical Data
Journal of Fungi, 2020 Rezafungin is a novel echinocandin drug being developed as a first-line option for treatment and prevention of invasive fungal infections. As a result of a structural modification in its parent molecule anidulafungin, rezafungin has acquired unique ...
Yanan Zhao, David S. Perlin
doaj +1 more source
Journal of Fungi, 2023 Invasive fungal infections (IFIs) are frequent and outcome-relevant complications in the early postoperative period after orthotopic liver transplantation (OLT).
Robert Breitkopf +4 more
doaj +1 more source
浙江大学学报. 农业与生命科学版, 2017 Echinocandins are the first class of antifungals to target fungal cell wall. Two antifungals, including micafungin and anidulafungin, have been widely used in clinic.
FENG Guodong +6 more
doaj +1 more source
Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.Candida spp. isolated from bottlenose dolphins under human care showed multirug resistance to common azoles. In vitro synergy testing revealed that certain antifungal combinations improved efficacy against resistant strains. Environmental monitoring using FISH detected Candida spp.
Barbara Biancani +6 more
wiley +1 more source