Results 51 to 60 of about 13,766 (257)

Caspofungin Induced Cell Wall Changes of Candida Species Influences Macrophage Interactions

open access: yesFrontiers in Cellular and Infection Microbiology, 2020
Candida species are known to differ in their ability to cause infection and have been shown to display varied susceptibilities to antifungal drugs. Treatment with the echinocandin, caspofungin, leads to compensatory alterations in the fungal cell wall ...
Louise A. Walker, Carol A. Munro
doaj   +1 more source

Epidemiology of Echinocandin Resistance in Candida [PDF]

open access: yesCurrent Fungal Infection Reports, 2014
Echinocandins are the newest antifungal agents approved for use in treating Candida infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to Candida cell death. There is no intrinsic resistance to echinocandins among Candida species, and isolates from historic collections archived
Shawn R. Lockhart   +2 more
openaire   +3 more sources

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

open access: yesAntibiotics, 2020
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar   +8 more
doaj   +1 more source

Continual Decline in Azole Susceptibility Rates in Candida tropicalis Over a 9-Year Period in China

open access: yesFrontiers in Microbiology, 2021
BackgroundThere have been reports of increasing azole resistance in Candida tropicalis, especially in the Asia-Pacific region. Here we report on the epidemiology and antifungal susceptibility of C. tropicalis causing invasive candidiasis in China, from a
Yao Wang   +172 more
doaj   +1 more source

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. [PDF]

open access: yes, 2016
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins.
Alexander, B.D.   +12 more
core   +1 more source

New Horizons in Antifungal Therapy

open access: yesJournal of Fungi, 2016
Recent investigations have yielded both profound insights into the mechanisms required by pathogenic fungi for virulence within the human host, as well as novel potential targets for antifungal therapeutics.
Kaila M. Pianalto, J. Andrew Alspaugh
doaj   +1 more source

Prognostic factors and historical trends in the epidemiology of candidemia in critically ill patients: an analysis of five multicenter studies sequentially conducted over a 9-year period [PDF]

open access: yes, 2014
To describe temporal trends in the epidemiology, clinical management and outcome of candidemia in intensive care unit (ICU) patients.This study was a retrospective analysis of 1,392 episodes of candidemia in 647 adult ICU patients from 22 Brazilian ...
Andreotti, Ricardo   +7 more
core   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

open access: yesChemistryEurope, EarlyView.
A standalone enzyme, derived from the reductase domain of a polyketide synthase‐nonribosomal peptide synthetase hybrid enzyme, is identified as a pyrroline carboxylate reductase. This enzyme is involved in the biosynthesis of 3‐methylproline, an amino acid building block of a unique tricyclic pyrrolizidinone structure of a fungal metabolite ...
Naoki Kato   +6 more
wiley   +1 more source

Review of the Novel Echinocandin Antifungal Rezafungin: Animal Studies and Clinical Data

open access: yesJournal of Fungi, 2020
Rezafungin is a novel echinocandin drug being developed as a first-line option for treatment and prevention of invasive fungal infections. As a result of a structural modification in its parent molecule anidulafungin, rezafungin has acquired unique ...
Yanan Zhao, David S. Perlin
doaj   +1 more source

Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India. [PDF]

open access: yes, 2019
Candida auris is an emerging multidrug-resistant yeast with high mortality. We report the sentinel C. auris case on the United States West Coast in a patient who relocated from India.
Crawford, Emily D   +12 more
core   +1 more source

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