Results 51 to 60 of about 23,261 (287)
Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]
, 2015 Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R +3 more
core +1 more source
Antimicrobial Agents and Chemotherapy, 2021 This study was designed to evaluate the prevalence of antifungal resistance, genetic mechanisms associated with in vitro induction of azole and echinocandin resistance and genotyping of Candida krusei, which is intrinsically resistant to fluconazole and ...
H. Khalifa +6 more
semanticscholar +1 more source
The Importance of Early Mycological Clearance of Uncomplicated Candidaemia and Its Implications for Clinical Practice. [PDF]
MycosesABSTRACT Invasive candidiasis is a life‐threatening infection associated with high morbidity, mortality and healthcare costs in both general and critical care settings. Timely diagnosis and adequate antifungal treatment are essential to improving patient outcomes and limiting unnecessary use of healthcare resources.
Cornely OA +7 more
europepmc +2 more sources
Tolerance and heteroresistance to echinocandins in <i>Candida auris</i>: conceptual issues, clinical implications, and outstanding questions. [PDF]
mSphereShor E, Perlin DS, Kontoyiannis DP.
europepmc +2 more sources
Current Opinion in Infectious Diseases, 2014 Echinocandin resistance in Candida is a great concern, as the echinocandin drugs are recommended as first-line therapy for patients with invasive candidiasis. Here, we review recent advances in our understanding of the epidemiology, underlying mechanisms, methods for detection and clinical implications.Echinocandin resistance has emerged over the ...
Maiken C, Arendrup, David S, Perlin
openaire +2 more sources
Cell Reports, 2018 Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan +6 more
doaj +1 more source
Analysis of molecular resistance to azole and echinocandin in Candida species in patients with vulvovaginal candidiasis [PDF]
Current Medical Mycology, 2022 Background and Purpose: Vulvovaginal candidiasis (VVC) is considered the most common mucosal infection caused by Candida species. Azoles were considered the firstline treatment for VVC or recurrent vulvovaginal candidiasis (RVVC) in both healthy and ...
Ensieh Lotfali +5 more
doaj +1 more source
Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin [PDF]
, 2014 We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them
Bizerra, Fernando Cesar +6 more
core +2 more sources
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta +6 more
wiley +2 more sources
浙江大学学报. 农业与生命科学版, 2017 Echinocandins are the first class of antifungals to target fungal cell wall. Two antifungals, including micafungin and anidulafungin, have been widely used in clinic.
FENG Guodong +6 more
doaj +1 more source