Results 61 to 70 of about 13,766 (257)

Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata. [PDF]

open access: yes, 2017
The echinocandins are relatively new antifungal drugs that represent, together with the older azoles, the recommended and/or preferred agents to treat candidaemia and other forms of invasive candidiasis in human patients.
De Carolis, E.   +6 more
core   +2 more sources

An investigation into the transcription factors and regulatory mechanisms of Aspergillus

open access: yesFood Safety and Health, EarlyView.
Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley   +1 more source

Echinocandin resistance in Candida parapsilosis sensu stricto: Role of alterations in CHS3, FKS1 and Rho gene expression

open access: yesJournal of Global Antimicrobial Resistance, 2020
Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari   +7 more
doaj  

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo

open access: yesmBio, 2022
Antifungal drug resistance and tolerance pose a serious threat to global public health. In the human fungal pathogen, Candida auris, resistance to triazole, polyene, and echinocandin antifungals is rising, resulting in multidrug resistant isolates. Here,
Laura S. Burrack   +4 more
doaj   +1 more source

Kajian Molekuler Resistensi Candida Albicans Terhadap Antifungi [PDF]

open access: yes, 2014
Candida albicans is one of the species Candida which mostly cause infection in human. Antifungal agent azole, polyene, echinocandin, and flucytosine are commonly used for Candida albicans infection treatment.
Candrasari, D. S. (Damiana)
core   +3 more sources

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

open access: yesChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas   +4 more
wiley   +1 more source

Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus

open access: yesMicrobiology Spectrum, 2022
Aspergillus fumigatus is a deadly opportunistic fungal pathogen responsible for ~100,000 annual deaths. Azoles are the first line antifungal agent used against A.
Shu Zhao   +7 more
doaj   +1 more source

Resistance in Candida albicans: exploring the cell wall barrier by proteomics [PDF]

open access: yes, 2015
The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients.
Angiolella, Letizia   +2 more
core   +1 more source

Evaluation of the Antifungal Properties of Azomethine‐Pyrazole Derivatives from a Structural Perspective

open access: yesChemistryOpen, EarlyView.
A series of azomethine‐pyrazole derivatives bearing a para‐substituted azo‐phenyl ring is straightforwardly prepared. The new compounds display an elevated antifungal activity against various Candida species and Cryptococcus neoformans strains. DFT and molecular docking calculations are used to determine possible routes of action through interactions ...
María Isabel Murillo   +8 more
wiley   +1 more source

Caspofungin Inhibits Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus and Displays Effectiveness in Coinfected Galleria mellonella Larvae

open access: yesMicrobiology Spectrum, 2021
Candida albicans and Staphylococcus aureus are pathogens commonly isolated from bloodstream infections worldwide. While coinfection by both pathogens is associated with mixed biofilms and more severe clinical manifestations, due to the combined ...
Gaby Scheunemann   +3 more
doaj   +1 more source

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