FDA-Approved Antibacterials and Echinocandins
AntibioticsSince 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA).
Othman Al Musaimi
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Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence [PDF]
Journal of Fungi, 2016 Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope.
Ethan R. Stewart, George R. Thompson
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Efficacy and safety of triazoles versus echinocandins in the treatment of invasive aspergillosis: A meta-analysis [PDF]
Vojnosanitetski Pregled, 2020 Backgroun/Aim. Although majority of guidelines recommend triazoles (voriconazole, posaconazole, itraconazole and isavuconazole) as first-line therapeutic option for treatment of invasive aspergillosis, echinocandins (caspofungin, micafungin and ...
Uzelac Sanja M. +4 more
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Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins
PLoS Pathogens, 2008 Echinocandins are a new generation of novel antifungal agent that inhibit cell wall beta(1,3)-glucan synthesis and are normally cidal for the human pathogen Candida albicans. Treatment of C.
Louise A Walker +2 more
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Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]
mBioEchinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus +13 more
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Prevalence and molecular basis of resistance to echinocandins among clinical Candida glabrata isolates in Guangdong province, China [PDF]
BMC MicrobiologyBackground Infections caused by Candida glabrata have raised increasing concerns, particularly due to the increasing resistance to echinocandins. Objectives This study investigated echinocandins susceptibility trends in C.
Weihong Lin +5 more
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Frontiers in Oncology, 2021 Invasive Candida glabrata infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient’s treatment is rarely recognised.
Maria Szymankiewicz +6 more
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The current place of echinocandins in the treatment and prophylaxis of invasive fungal infections [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality.
Veselov A.V.
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Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]
, 2011 Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
A Lupetti +69 more
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Journal of Fungi, 2023 This study aimed to evaluate the effectiveness of fluconazole and echinocandins in the treatment of candidemia caused by both fluconazole- and echinocandin-susceptible common Candida species. A retrospective study which enrolled adult candidemia patients
Jong Hun Kim, Jin Woong Suh, Min Ja Kim
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