Results 1 to 10 of about 10,352 (170)

Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins

PLoS Pathogens, 2008
Echinocandins are a new generation of novel antifungal agent that inhibit cell wall beta(1,3)-glucan synthesis and are normally cidal for the human pathogen Candida albicans. Treatment of C.
Louise A Walker, Carol Anne Munro, Irene de Bruijn   +2 more
exaly   +3 more sources

Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition

Nature Communications
Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited.
Tuo Wang, Ping Wang, Andrew S Lipton
exaly   +2 more sources

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]

mBio
Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus, Judith Díaz-García, Vladislav Biriukov, Stef Jacobs, Dimitrios Sofras, Alicia Pageau, Celia Lobo Romero, Lore Vinken, Pilar Escribano, Jesús Guinea, Katrien Lagrou, Christian R. Landry, Toni Gabaldón, Patrick Van Dijck   +13 more
doaj   +2 more sources

Prevalence and molecular basis of resistance to echinocandins among clinical Candida glabrata isolates in Guangdong province, China [PDF]

BMC Microbiology
Background Infections caused by Candida glabrata have raised increasing concerns, particularly due to the increasing resistance to echinocandins. Objectives This study investigated echinocandins susceptibility trends in C.
Weihong Lin, Yaqin Peng, Bo Xiang, Jingchun Fang, Junkai Ye, Penghao Guo   +5 more
doaj   +2 more sources

Efficacy and safety of triazoles versus echinocandins in the treatment of invasive aspergillosis: A meta-analysis [PDF]

Vojnosanitetski Pregled, 2020
Backgroun/Aim. Although majority of guidelines recommend triazoles (voriconazole, posaconazole, itraconazole and isavuconazole) as first-line therapeutic option for treatment of invasive aspergillosis, echinocandins (caspofungin, micafungin and ...
Uzelac Sanja M., Živković-Zarić Radica S., Radovanović Milan R., Ranković Goran Ž., Jankovic Slobodan M.   +4 more
doaj   +1 more source

Case Report: Echinocandin-Resistance Candida glabrata FKS Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer

Frontiers in Oncology, 2021
Invasive Candida glabrata infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient’s treatment is rarely recognised.
Maria Szymankiewicz, Krzysztof Kamecki, Sylwia Jarzynka, Anna Koryszewska-Bagińska, Gabriela Olędzka, Tomasz Nowikiewicz, Tomasz Nowikiewicz   +6 more
doaj   +1 more source

The current place of echinocandins in the treatment and prophylaxis of invasive fungal infections [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2020
Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality.
Veselov A.V.
doaj   +1 more source

Evaluation of Fluconazole versus Echinocandins for Treatment of Candidemia Caused by Susceptible Common Candida Species: A Propensity Score Matching Analysis

Journal of Fungi, 2023
This study aimed to evaluate the effectiveness of fluconazole and echinocandins in the treatment of candidemia caused by both fluconazole- and echinocandin-susceptible common Candida species. A retrospective study which enrolled adult candidemia patients
Jong Hun Kim, Jin Woong Suh, Min Ja Kim
doaj   +1 more source

In Vitro Characterization of Twenty-One Antifungal Combinations against Echinocandin-Resistant and -Susceptible Candida glabrata

Journal of Fungi, 2021
This study was designed to analyze the interaction of 21 antifungal combinations consisting of seven major antifungal agents against 11 echinocandin- susceptible and six-resistant C. glabrata isolates. The combinations were divided into five major groups
Hazim O. Khalifa, Hidetaka Majima, Akira Watanabe, Katsuhiko Kamei   +3 more
doaj   +1 more source

Review on Current Status of Echinocandins Use

Antibiotics, 2020
Fungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine.
Martyna Mroczyńska, Anna Brillowska-Dąbrowska   +1 more
doaj   +1 more source