Echinocandins are a first-line therapy for candidemia and invasive candidiasis. They are generally safe with few drug interactions, but the stability and pharmacokinetic properties of currently approved echinocandins are such that each was developed for ...
K. D. James+4 more
semanticscholar +1 more source
OBJECTIVES A polymorphism in the gene encoding β-1,3-glucan synthase, the target of the echinocandin class of antifungals, results in increased in vitro MICs of the echinocandins.
K. Chiotos+6 more
semanticscholar +1 more source
Echinocandin Resistance in Two Candida haemulonii Isolates from Pediatric Patients [PDF]
We report 3 cases of patients with Candida haemulonii isolates that were obtained from hemocultures. in 2 of the 3 cases, isolates exhibited resistance to echinocandins and fluconazole.
Azevedo Melo, Analy Salles de+4 more
core +1 more source
The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]
Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K+11 more
core +3 more sources
Susceptibility testing of Candida glabrata clinical strains to echinocandins using SensititreTM YeastOneTM system [PDF]
Objective. To determine susceptibility of C. glabrata isolates to anidulafungin, caspofungin and micafungin using the SensititreTM YeastOneTM system. Materials and Methods. C. glabrata isolates were taken prospectively from clinical specimens or from
Veselov A.V.+11 more
doaj
An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry [PDF]
Background: Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin.
Kirchhoff, Fabian+5 more
core +1 more source
We examined the rapid evaluation of susceptibility to echinocandins in Candida spp. using the Etest performed directly on positive blood cultures and anidulafungin-containing agar plates.
M. Bordallo-Cardona+6 more
semanticscholar +1 more source
The problem of systemic candidosis after transplantation of solid organs. Review of the literature
The article presents current views on the epidemiology, diagnosis and treatment of candidosis with organ transplantation.
S. V. Zhuravel+2 more
doaj +1 more source
Primary Antifungal Prophylaxis in Adult Hematopoietic Stem Cell Transplant Recipients: Current Therapeutic Concepts [PDF]
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90237/1/phco.29.11.1306 ...
Carver, Peggy L.+2 more
core +1 more source
Adverse events of modern antifungal drugs during treatment of invasive fungal infections
Characteristics of adverse events of modern antimycotics by organ systems and comparative frequency between different medicines and their groups are presented.
N. V. Dmitrieva, I. N. Petukhova
doaj +1 more source