Results 31 to 40 of about 21,210 (293)

The Elevated Endogenous Reactive Oxygen Species Contribute to the Sensitivity of the Amphotericin B-Resistant Isolate of Aspergillus flavus to Triazoles and Echinocandins

Frontiers in Microbiology, 2021
Aspergillus flavus has been frequently reported as the second cause of invasive aspergillosis (IA), as well as the leading cause in certain tropical countries.
Tianyu Liang, Wei Chen, Xinyu Yang, Qiqi Wang, Zhe Wan, Ruoyu Li, Wei Liu   +6 more
doaj   +1 more source

Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]

, 2015
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R, Lee, Keunsook, Munro, Carol A, Walker, Louise A   +3 more
core   +1 more source

Antifungal drug susceptibility, molecular basis of resistance to echinocandins and molecular epidemiology of fluconazole resistance among clinical Candida glabrata isolates in Kuwait

Scientific Reports, 2020
Candida glabrata readily develops resistance to echinocandins. Identification, antifungal susceptibility testing (AST) and resistance mechanism to echinocandins among C. glabrata was determined in Kuwait. C.
Zahraa F. Al-Baqsami, Suhail Ahmad, Z. Khan   +2 more
semanticscholar   +1 more source

Susceptibility of the Candida haemulonii Complex to Echinocandins: Focus on Both Planktonic and Biofilm Life Styles and a Literature Review

Journal of Fungi, 2020
Candida haemulonii complex (C. haemulonii, C. duobushaemulonii and C. haemulonii var. vulnera) is well-known for its resistance profile to different available antifungal drugs.
Lívia S. Ramos, Laura N. Silva, Marta H. Branquinha, André L. S. Santos   +3 more
doaj   +1 more source

In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades

Pharmaceutics, 2023
Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C.
Awid Adnan, Andrew M. Borman, Zoltán Tóth, Lajos Forgács, Renátó Kovács, Dávid Balázsi, Bence Balázs, Gergely Udvarhelyi, Gábor Kardos, László Majoros   +9 more
doaj   +1 more source

Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]

, 2017
This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N, Istel, F, Jenull, S, Lion, T, Nogueira, MF, Walker, L A   +5 more
core   +1 more source

Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death [PDF]

, 2014
Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Austriaco, Nicanor, Chin, Christopher, Donaghey, Faith, Helming, Kathrine, McCarthy, Morgan, Rogers, Stephen   +5 more
core   +3 more sources

Attributable mortality of candidemia after introduction of echinocandins

Mycoses (Berlin), 2020
Candidemia is among the most frequent nosocomial bloodstream infections. Landmark case‐control studies on amphotericin B and fluconazole estimated attributable mortality rates of 38% and 49%, respectively.
Florian B. Cornely, O. Cornely, J. Salmanton-García, F. Koehler, P. Koehler, H. Seifert, S. Wingen-Heimann, Sibylle C. Mellinghoff   +7 more
semanticscholar   +1 more source

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, Elena Eraso, Guillermo Quindós, Nerea Jauregizar   +3 more
doaj   +1 more source

Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins

Antibiotics, 2021
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu   +9 more
doaj   +1 more source