Results 31 to 40 of about 17,763 (261)
The seizure of illicit assets: patterns of civil forfeiture in Canada and Ireland [PDF]
, 2013 No description ...
Gallant, M Michelle, King, Colin
core +1 more source
Fungal infections of the central nervous system: A review of fungal pathogens and treatment [PDF]
, 2007 Multiple factors influence the outcome of fungal infection of the central nervous system (CNS). The host and the pathogen in concert with drug delivery across the blood-brain barrier and drug activity are key factors in outcome.
Dancer, C., Redmond, A., Woods, M. L.
core +1 more source
Current Opinion in Infectious Diseases, 2014 Echinocandin resistance in Candida is a great concern, as the echinocandin drugs are recommended as first-line therapy for patients with invasive candidiasis. Here, we review recent advances in our understanding of the epidemiology, underlying mechanisms, methods for detection and clinical implications.Echinocandin resistance has emerged over the ...
Maiken C, Arendrup, David S, Perlin
openaire +2 more sources
Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein ...
Jiří Houšť +2 more
doaj +1 more source
Journal of Fungi, 2021 This study was designed to analyze the interaction of 21 antifungal combinations consisting of seven major antifungal agents against 11 echinocandin- susceptible and six-resistant C. glabrata isolates. The combinations were divided into five major groups
Hazim O. Khalifa +3 more
doaj +1 more source
Fungal biofilm resistance [PDF]
, 2012 Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Rajendran, Ranjith +3 more
core +4 more sources
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta +6 more
wiley +2 more sources
Cell Reports, 2018 Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan +6 more
doaj +1 more source
Frontiers in Microbiology, 2021 Aspergillus flavus has been frequently reported as the second cause of invasive aspergillosis (IA), as well as the leading cause in certain tropical countries.
Tianyu Liang +6 more
doaj +1 more source
Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death [PDF]
, 2014 Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Austriaco, Nicanor +5 more
core +3 more sources