Results 51 to 60 of about 21,836 (300)
The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on Recovery of the β-1,3-Glucan Synthase Fks1 [PDF]
Antimicrobial Agents and Chemotherapy, 2016 Veronika Loiko, Johannes Wagener
openalex +2 more sources
Cell Reports, 2018 Summary: Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is readily acquired via mutations in the drug target gene, FKS1.
Tavia Caplan +6 more
doaj +1 more source
Echinocandins as Biotechnological Tools for Treating Candida auris Infections
Journal of Fungi, 2020 Candida auris has been reported in the past few years as an invasive fungal pathogen of high interest. Its recent emergence in healthcare-associated infections triggered the efforts of researchers worldwide, seeking additional alternatives to the use of ...
E. Cândido +3 more
semanticscholar +1 more source
Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin [PDF]
, 2014 We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them
Bizerra, Fernando Cesar +6 more
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Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.Cryptococcus neoformans cell wall α‐1,3‐glucans as dual anchors for melanin and capsule: Solid‐state NMR of intact C. neoformans cells reveals five forms of α‐1,3‐glucans that structurally bridge melanin and capsule layers. These polysaccharides interact with chitin, chitosan, and β‐glucans to create a molecular scaffold that underlies virulence and ...
Ankur Ankur +11 more
wiley +2 more sources
Some issues of the resistance of Candida glabrata to echinocandins [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2019 Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida ...
Veselov A.V.
doaj +1 more source
Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death [PDF]
, 2014 Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Austriaco, Nicanor +5 more
core +3 more sources
Cdc14 phosphatase contributes to cell wall integrity and pathogenesis in Candida albicans
Frontiers in Microbiology, 2023 The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae, Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit.
Kedric L. Milholland +15 more
doaj +1 more source
Role of Antifungal Combinations in Difficult to Treat Candida Infections
Journal of Fungi, 2021 Candida infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. C. albicans is the most prevalent species isolated, however, a significant shift towards other Candida species has been noted ...
Roxana G. Vitale
doaj +1 more source
G3: Genes, Genomes, Genetics, 2016 Candida glabrata is an important human fungal pathogen whose incidence continues to rise. Because many clinical isolates are resistant to azole drugs, the drugs of choice to treat such infections are members of the echinocandin family, although there are
Anne G. Rosenwald +8 more
doaj +1 more source