Results 71 to 80 of about 12,460 (212)

Epidemiology of Echinocandin Resistance in Candida [PDF]

Current Fungal Infection Reports, 2014
Echinocandins are the newest antifungal agents approved for use in treating Candida infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to Candida cell death. There is no intrinsic resistance to echinocandins among Candida species, and isolates from historic collections archived
Nina T, Grossman, Tom M, Chiller, Shawn R, Lockhart   +2 more
openaire   +2 more sources

Unresolving Pneumonia in Type 2 Diabetes: Case Report of Polymicrobial Lung Disease

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Polymicrobial pneumonia caused by the simultaneous infection with multiple pathogens is increasingly recognized in individuals with comorbidities such as type 2 diabetes mellitus (T2DM). The immunocompromised state associated with T2DM predisposes patients to both typical and opportunistic infections, including multidrug‐resistant bacteria and
Micheal Collins Segawa
wiley   +1 more source

Review of the guidelines for the treatment and prevention of invasive candidiasis in newborns and children [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2017
nvasive infections caused by Candida species are the most common invasive fungal infections in children of different age groups. Premature neonates, especially newborns with low and extremely low birth-weight, have very high mortality rates, with the ...
Veselov A.V.
doaj  

[Echinocandins].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2012
The echinocandins, caspofugin, micafungin, and anidulafungin, are lipopeptides that inhibit fungal growth by binding to β - (1.3) d glucan synthase. This enzyme is responsible for the formation of the peptidoglycan cell wall, and it is essential in fungi such as Candida spp, but less important in the case of Aspergillus and Fusarium species.
Jorge A, Cortés L, July A, Russi N
openaire   +1 more source

Probiotic‐based strategies in vulvovaginal candidiasis management: A comprehensive review of mechanisms and future directions

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review focuses on vulvovaginal candidiasis (VVC), examining its epidemiology, the pathogenesis of Candida albicans, and its relationships with vaginal microbiota. It comprehensively reviews probiotic‐based management strategies and their mechanisms of action, and concludes by discussing current limitations, challenges and future research ...
Tong Chen, Yuwei Wu, Ya Chen, Ying Li, Hui Zhao, Lei Wu, He Gao, Tong Jiang, Xiaohong Wang, Moutong Chen, Jumei Zhang, Xinqiang Xie, Tingting Liang, Qingping Wu   +13 more
wiley   +1 more source

Echinocandins and Continuous Renal Replacement Therapies: The Role of Adsorption

, 2018
The following reviews [1,2], about continuous renal replacement therapies (CRRT) and echinocandins conclude that the membranes do not significantly adsorb these antifungals. The first review [1], that evaluates several articles [3-7], concludes that the
TM Tomasa Irriguible, T m Tomasa Irriguible   +1 more
core   +1 more source

Antifungal Drugs

Metabolites, 2020
We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein ...
Jiří Houšť, Jaroslav Spížek, Vladimír Havlíček   +2 more
doaj   +1 more source

Repositioning 2‐Mercaptobenzothiazole and Sulfonamides as Antifungals Against Multidrug‐Resistant Candida albicans: In Vitro and In Silico Insights

ChemistrySelect, Volume 11, Issue 19, 20 May 2026.
This study highlights the antifungal potential of 2‐mercaptobenzothiazole (MBT) and sulfonamides against multidrug‐resistant Candida albicans. In vitro assays and molecular docking with lanosterol 14α‐demethylase (L14αDM) reveal favorable activity and binding, supporting their repositioning as promising antifungal candidates. ABSTRACT Fungal infections
Bruno A. de Oliveira, Ari Sérgio de Oliveira Lemos, Gabrielle Silva de Campos Lazzarini, Natasha Silva Mayrink, Elaine Soares Coimbra, Adilson D. da Silva, Rodrigo Luiz Fabri   +6 more
wiley   +1 more source

Impact of special patient populations on the pharmacokinetics of echinocandins

, 2015
Contains fulltext : 153098.pdf (Publisher’s version ) (Open Access)Echinocandins belong to the class of antifungal agents. Currently, three echinocandin drugs are licensed for intravenous treatment of invasive fungal infections ...
Burger, D.M., Warris, A., Muilwijk, E.W., Pickkers, P., Aarnoutse, R.E., Lempers, V.J.C., Bruggemann, R.J.M.   +6 more
core   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, Volume 116, Issue 5, Page 625-634, May 2026.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source