Results 71 to 80 of about 12,522 (211)

Echinocandins: A promising new antifungal group [PDF]

, 2004
Echinocandins are a new option for fungal infections. They are fungicidal and less toxic to the host by virtue of their novel mechanism of action. They are b-1, 3-glucan synthase inhibitors.
G. Sharma, G. K. Randhawa
core   +1 more source

Correction: The Effect on Mortality of Fluconazole or Echinocandins Treatment in Candidemia in Internal Medicine Wards [PDF]

, 2015
Correction: The Effect on Mortality of Fluconazole or Echinocandins Treatment in Candidemia in Internal Medicine ...
PLOS ONE (2189197)
core   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, Volume 13, Issue 41, 22 July 2026.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species. [PDF]

, 2016
The echinocandins and liposomal amphotericin B are active against biofilm produced by echinocandin-susceptible Candida strains. However, few data have been reported on the production of biofilm by echinocandin-resistant isolates and their antifungal ...
Marcos-Zambrano, Laura Judith, Gómez-Perosanz, Marta, Escribano, Pilar, Bouza, Emilio, Guinea, Jesús, Zaragoza, Oscar   +5 more
core   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2250-2259, July 2026.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Microcolony Imaging of Aspergillus fumigatus Treated with Echinocandins Reveals Both Fungistatic and Fungicidal Activities [PDF]

, 2012
Background: The echinocandins are lipopeptides that can be employed as antifungal drugs that inhibit the synthesis of 1,3-beta-glucans within the fungal cell wall.
Ingham, C.J., Schneeberger, P.M., Peter M Schneeberger, Colin J Ingham, Schneeberger Peter M., Ingham Colin J.   +5 more
core   +1 more source

Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor

G3: Genes, Genomes, Genetics, 2016
Candida glabrata is an important human fungal pathogen whose incidence continues to rise. Because many clinical isolates are resistant to azole drugs, the drugs of choice to treat such infections are members of the echinocandin family, although there are
Anne G. Rosenwald, Gaurav Arora, Rocco Ferrandino, Erica L. Gerace, Maedeh Mohammednetej, Waseem Nosair, Shemona Rattila, Amanda Zirzow Subic, Ronda Rolfes   +8 more
doaj   +1 more source

Combination Antifungal Therapy and Formulary Optimization for Progressive Invasive Pulmonary Aspergillosis in a Pediatric Patient With Acute Myeloid Leukemia: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Therapeutic response in refractory invasive pulmonary aspergillosis may depend not only on antifungal class escalation, but also on formulation choice. In this complex pediatric acute myeloid leukemia (AML) case, radiologic improvement followed combination therapy and switch to brand‐name liposomal amphotericin B, underscoring the importance ...
Faryal Khamis, Amal Al Busaidi, Kawther Al Bahrani, Asia Al‐Rashdi   +3 more
wiley   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

Coagulation dysfunction events associated with echinocandins: a real-world study from FDA adverse event reporting system (FAERS) database

Thrombosis Journal
Background Echinocandins belong to the fourth generation of antifungals, and there are no systematic studies on their risk in coagulation dysfunction; this study will predict the risk of coagulation dysfunction of echinocandins using the US Food and Drug
Qian Cheng, Ye Wu, Zeyu Yao, Mengling Ouyang, Shupeng Zou, Xuan Shi, Yazheng Zhao, Minghui Sun   +7 more
doaj   +1 more source