Results 71 to 80 of about 22,252 (260)

Antifungal effects of echinocandins diminish when exposed to intestinal lumen contents: a finding with potentially significant clinical implications

Frontiers in Pharmacology
Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungin, the two most
Sepideh Mehravar, Gabriela S. Leite, Mark Pimentel, Mark Pimentel, Ali Rezaie, Ali Rezaie   +5 more
doaj   +1 more source

Cdc14 phosphatase contributes to cell wall integrity and pathogenesis in Candida albicans

Frontiers in Microbiology, 2023
The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae, Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit.
Kedric L. Milholland, Ahmed AbdelKhalek, Kortany M. Baker, Smriti Hoda, Andrew G. DeMarco, Noelle H. Naughton, Angela N. Koeberlein, Gabrielle R. Lorenz, Kartikan Anandasothy, Antonio Esperilla-Muñoz, Sanjeev K. Narayanan, Jaime Correa-Bordes, Scott D. Briggs, Scott D. Briggs, Mark C. Hall, Mark C. Hall   +15 more
doaj   +1 more source

Comparative evaluation of Sensititre YeastOne and CLSI M38-Ed3 reference method for determining echinocandin minimum effective concentrations against Aspergillus isolates

Microbiology Spectrum
The minimum inhibitory concentration (MIC) of echinocandins against Aspergillus spp. does not represent the actual inhibition threshold of echinocandins.
Assaf Potruch, Hila Elinav, Matan J. Cohen, Alexander Rouvinski, Itzhack Polacheck, Maya Korem   +5 more
doaj   +1 more source

An Overview of Recent Possibilities in Pharmacotherapy of Diseases of the Oral Mucosa, Salivary Glands, and Periodontal Tissue

Česká Stomatologie a Praktické Zubní Lékařství, 2013
Introduction: A review of newer drugs for topical or systemic administration useful in contemporary dentistry in the therapy of diseases of periodontal tissue, oral mucous membrane, and salivary glands available in Czech Republic was given in this ...
R. Slezák, I. Lindrová, V. Buchta, V. Paulusová, Z. Šustová, O. Kopecký, L. Ryšková   +6 more
doaj   +1 more source

Role of Antifungal Combinations in Difficult to Treat Candida Infections

Journal of Fungi, 2021
Candida infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. C. albicans is the most prevalent species isolated, however, a significant shift towards other Candida species has been noted ...
Roxana G. Vitale
doaj   +1 more source

Variability in antifungal and antiviral use in hospitalized children [PDF]

, 2017
We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals.
Gerber, Jeffrey S, Goldman, Jennifer L, Hersh, Adam L, Kronman, Matthew P, Lee, Brian R, Newland, Jason G, Ross, Rachael K   +6 more
core   +2 more sources

Echinocandins Pharmacokinetics: A Comprehensive Review of Micafungin, Caspofungin, Anidulafungin, and Rezafungin Population Pharmacokinetic Models and Dose Optimization in Special Populations

Clinical Pharmacokinetics
In recent years, many population pharmacokinetic (popPK) models have been developed for echinocandins to better understand the pharmacokinetics (PK) of these antifungals.
M. Albanell-Fernández
semanticscholar   +1 more source

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species

Cells, 2023
Candidiasis is a highly pervasive infection posing major health risks, especially for immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired resistance to a variety of antifungal medications.
Karolina M. Czajka, Krishnan Venkataraman, Danielle Brabant-Kirwan, Stacey A. Santi, Chris Verschoor, Vasu D. Appanna, Ravi Singh, Deborah P. Saunders, Sujeenthar Tharmalingam   +8 more
doaj   +1 more source

Pitfalls associated with the use of molecular diagnostic panels in the diagnosis of cryptococcal meningitis [PDF]

, 2017
We report the case of a kidney transplantation patient on chronic immunosuppressive therapy presenting with subacute meningitis. The final diagnosis of cryptococcal meningitis was delayed due to 2 false-negative cryptococcal results on a molecular ...
Burnham, Carey-Ann, Dubberke, Erik, Franklin, Alexander, Lainhart, William, O\u27Halloran, Jane A, Powderly, William   +5 more
core   +2 more sources

Comparative efficacies of the three echinocandins for Candida auris candidemia: real world evidence from a tertiary centre in India

Medical Mycology
Though echinocandins are the first line of therapy for C. auris candidemia, there is little clinical data to guide the choice of therapy within this class.
P. Prayag, S. Patwardhan, Rasika S Joshi, Surabhi Dhupad, Tejashree Rane, A. Prayag   +5 more
semanticscholar   +1 more source