Purinergic regulation of pulmonary vascular tone. [PDF]
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ATP released by ultrasound targeted microbubble cavitation induces vascular inflammation and improves immune checkpoint blockade efficacy. [PDF]
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Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action? [PDF]
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Growth regulation by apyrases: Insights from altering their expression level in different organisms. [PDF]
Clark G, Tripathy MK, Roux SJ.
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Methanol alters ecto-nucleotidases and acetylcholinesterase in zebrafish brain
Neurotoxicology and Teratology, 2006Methanol is a neurotoxic compound that is responsible for serious damage on CNS. Besides being found as an environmental contaminant, this alcohol is also employed as a component of cryoprotector solutions for zebrafish embryos. Here we tested the acute effect of methanol on ecto-nucleotidase (NTPDase, ecto-5'-nucleotidase) and acetylcholinesterase ...
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Polyoxometalates—Potent and selective ecto-nucleotidase inhibitors
Biochemical Pharmacology, 2015Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms of action at the molecular level are largely unknown.
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Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline
European Journal of Pharmacology, 2008Depression is one of the most disabling diseases and causes a significant burden to both individual and society. Selective serotonin reuptake inhibitors and tricyclic antidepressants, such as fluoxetine and nortriptyline, respectively, are commonly used in treatment for depression.
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This study investigated the characteristics of ecto-nucleotidases in tissues lining the perilymphatic cavity of the cochlea. The perilymphatic space of the isolated guinea-pig cochlea was maintained with oxygenated artificial perilymph (AP) perfused at a rate of 100 microl/min.
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Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery
Mini-Reviews in Medicinal Chemistry, 2015Ecto-nucleotidases are nucleotide metabolizing enzymes that are divided into four different families; nucleoside triphosphate diphosphohydrolases (NTPDases), ecto-5'-nucleotidase (ecto-5'-NT), nucleotide pyrophosphatase/phosphodiesterases (NPPs), and alkaline phosphatases (APs).
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(ECTO)NUCLEOTIDASE KINETICS OBSERVED BY31P-NMR SPECTROSCOPY: RESOLUTION OF SIGNALS
Pharmacological Research, 1997We used 31P-NMR to study the action of the drug ouabain, a digitalis glycoside, on the ecto-nucleotidase catalysed reaction pathway: [formula: see text] Even under conditions where it was impossible to resolve all resonances from the individual species, the rate constants for the individual steps may be evaluated by a chi 2 fit of equations describing ...
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