Results 151 to 160 of about 2,507 (197)

Purinergic regulation of pulmonary vascular tone. [PDF]

open access: yesPurinergic Signal
Alveal M   +3 more
europepmc   +1 more source
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Methanol alters ecto-nucleotidases and acetylcholinesterase in zebrafish brain

Neurotoxicology and Teratology, 2006
Methanol is a neurotoxic compound that is responsible for serious damage on CNS. Besides being found as an environmental contaminant, this alcohol is also employed as a component of cryoprotector solutions for zebrafish embryos. Here we tested the acute effect of methanol on ecto-nucleotidase (NTPDase, ecto-5'-nucleotidase) and acetylcholinesterase ...
Eduardo Pacheco Rico   +2 more
exaly   +3 more sources

Polyoxometalates—Potent and selective ecto-nucleotidase inhibitors

Biochemical Pharmacology, 2015
Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms of action at the molecular level are largely unknown.
Lee, S.-Y.   +13 more
openaire   +3 more sources

Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline

European Journal of Pharmacology, 2008
Depression is one of the most disabling diseases and causes a significant burden to both individual and society. Selective serotonin reuptake inhibitors and tricyclic antidepressants, such as fluoxetine and nortriptyline, respectively, are commonly used in treatment for depression.
Eduardo Luiz, Pedrazza   +7 more
openaire   +2 more sources

The pharmacology and kinetics of ecto-nucleotidases in the perilymphatic compartment of the guinea-pig cochlea

Hearing Research, 1998
This study investigated the characteristics of ecto-nucleotidases in tissues lining the perilymphatic cavity of the cochlea. The perilymphatic space of the isolated guinea-pig cochlea was maintained with oxygenated artificial perilymph (AP) perfused at a rate of 100 microl/min.
Srdjan M Vlajkovic   +2 more
exaly   +3 more sources

Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery

Mini-Reviews in Medicinal Chemistry, 2015
Ecto-nucleotidases are nucleotide metabolizing enzymes that are divided into four different families; nucleoside triphosphate diphosphohydrolases (NTPDases), ecto-5'-nucleotidase (ecto-5'-NT), nucleotide pyrophosphatase/phosphodiesterases (NPPs), and alkaline phosphatases (APs).
openaire   +2 more sources

(ECTO)NUCLEOTIDASE KINETICS OBSERVED BY31P-NMR SPECTROSCOPY: RESOLUTION OF SIGNALS

Pharmacological Research, 1997
We used 31P-NMR to study the action of the drug ouabain, a digitalis glycoside, on the ecto-nucleotidase catalysed reaction pathway: [formula: see text] Even under conditions where it was impossible to resolve all resonances from the individual species, the rate constants for the individual steps may be evaluated by a chi 2 fit of equations describing ...
Bernardi, M.   +6 more
openaire   +3 more sources

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