Results 51 to 60 of about 1,822 (135)

pH-dependent effects of lidocaine on defibrillation energy requirements in dogs.

, 1989
Lidocaine increases the energy required for ventricular defibrillation in dogs. Because sodium channel-blocking agents that are weak bases have pH-dependent electrophysiologic effects, we investigated the pH dependence of lidocaine (pKa, 7.9) on internal
E L Cato, D R Coxe, D S Echt
core   +1 more source

An Adequate Infusion Rate of Remimazolam for Induction of General Anesthesia in Adult Patients: A Prospective Up-and-Down Dose-Finding Study

, 2023
Remimazolam is a recently developed anesthetic agent for general anesthesia and sedation. Currently, the optimal infusion rate for the induction of general anesthesia within two minutes remains unclear.
Hyun Joo Ahn, Heejoon Jeong, Hara Kim
core   +1 more source

Glycoprotein Non‐Metastatic Melanoma Protein B (GPNMB): A Translational Pharmacodynamic Biomarker for PIKfyve Inhibition With VRG50635

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Glycoprotein non‐metastatic melanoma protein B (GPNMB) was investigated as a pharmacodynamic (PD) biomarker for PIKfyve inhibition across translational studies ex vivo, in vitro, in animals, and in the clinic, demonstrating significant response to VRG50468 in cells, in vivo in the central nervous system (CNS) and in peripheral fluids and ...
Geraldine Gontier, Grace Kim, Chao Wang, Kevin Zhu, Raymond Gau, Ningzhe Zhang, Swati Naphade, Alistair Stewart, Martin J. Schmidt, Robert Galemmo, Brian Shook, Anil Tarachandani, Irene Choi, Shane Raines, Robert H. Scannevin, Henrieke W. Grievink, Lars M. G. Smits, Philip H. C. Kremer, Diego Cadavid   +18 more
wiley   +1 more source

Cardiovascular and Neuromuscular Effects of Three Steroidal Neuromuscular Blocking Drugs in Dogs (ORG 9616, ORG 9426, ORG 9991)

, 1990
Developmental research has been directed toward creating nondepolarizing muscle relaxants with an onset time and duration of actions shorter than that of vecuronium or atracurium.
Agoston, Sandor, Hickey, Robert F., Baker, David G., Cason, Brian, Miller, Ronald D.   +4 more
core   +1 more source

The role of child language ability and parental mentalization in early child dysregulation

Infant Mental Health Journal: Infancy and Early Childhood, Volume 47, Issue 1, January 2026.
Abstract Dysregulation in early childhood is associated with increased vulnerability to psychopathology and poor psychosocial outcomes. While there is evidence that both child language ability and parental mentalization are associated with dysregulation in early childhood, there is little understanding of the relationships between these variables, and ...
Sara Cibralic, Mary Xu, Nancy Wallace, Susan Morgan, Angelique Roth, Hannah Chau, Jane Kohlhoff   +6 more
wiley   +1 more source

A biased coin up-and-down sequential allocation trial to determine the ED90 of intrathecal sufentanil combined with ropivacaine 2.5 mg for labor analgesia

Frontiers in Medicine
PurposeTo determine the 90 percent effective dose (ED90) of intrathecal sufentanil combined with ropivacaine 2.5 mg for labor analgesia and observe its safety for parturients and neonates.MethodsWe conducted a prospective, double-blind, biased coin up ...
Qiaoli Yin, Qiaoli Yin, Bin Yu, Hua Hao, Gang Li, Junyan Sun, Junyan Sun, Hao Kong, Liqin Deng   +8 more
doaj   +1 more source

Developmental Patterns of Hepatic Peroxisome Proliferator‐Activated Receptor (PPAR) Expression in Xenopus laevis and Response to Pharmaceutical Agonists During Metamorphic Climax

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 343, Issue 10, Page 1191-1204, December 2025.
ABSTRACT Peroxisome proliferator‐activated receptors (PPAR) are master transcriptional regulators that maintain metabolic homeostasis in vertebrates. Amphibians are often exposed to endocrine disrupting compounds (EDCs) that could dysregulate lipid metabolism.
Anna Bushong, Tyler D. Hoskins, Meredith Scherer, Maria S. Sepúlveda   +3 more
wiley   +1 more source

Detecting ALS and ACCase herbicide tolerant accession of Echinochloa oryzoides (Ard.) Fritsch. in rice (Oryza sativa L.) fields

, 2014
Inconsistent control of Echinochloa oryzoides has been reported repeatedly by farmers in the major rice growing area of Turkey. Greenhouse studies confirmed the existence of cross and multiple herbicide tolerance of E.
Streibig, Jens Carl, Altop, Ernine Kaya, Budak, Unal, Mennan, Husrev, Ritz, Christian, Altop, Emine Kaya   +5 more
core   +1 more source

Leveraging recent advances in plasma biomarkers to optimize early proof of concept trials in Alzheimer's disease

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 4, October-December 2025.
Abstract INTRODUCTION The importance of biomarkers as a primary outcome or as supportive evidence of clinical effect is rising as the field shifts toward disease‐modifying treatments and earlier intervention, because they have lower variability and can indicate disease progression earlier than clinical outcomes.
Garrett B. Duncan, Samuel P. Dickson, Johanne M. Kaplan, Samuel B. Johnson, Tyler M. Duke, Caleb W. Dayley, Suzanne B. Hendrix, Larry D. Altstiel, Craig H Mallinckrodt   +8 more
wiley   +1 more source

Steaming soil is effective in eliminating invasive alien plants (IAPs) – part II: effect of soil type

Pest Management Science, Volume 81, Issue 9, Page 5543-5550, September 2025.
Incorporation of propagative materials of selected invasive alien plant species in the soil. Steam treatment targeting different soil temperatures using a soil steaming prototype device. Fitted dose‐response curves showing the mortality rate obtained at different soil temperatures.
Zahra Bitarafan, Wiktoria Kaczmarek‐Derda, Therese W Berge, Inger Sundheim Fløistad, Christian Andreasen   +4 more
wiley   +1 more source