Results 111 to 120 of about 4,495,962 (263)
Advanced Science, EarlyView.ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao +7 more
wiley +1 more source
Update in treatment of uveitic macular edema
, 2019 Spyridon Koronis,1 Panagiotis Stavrakas,2 Miltiadis Balidis,1 Nikolaos Kozeis,1 Paris G Tranos1 1Ophthalmica Eye Institute, Thessaloniki, Greece; 2Department of Ophthalmology, Attikon University Hospital, Athens, Greece Abstract: Macular edema (ME ...
Koronis S +4 more
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Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants
Advanced Science, EarlyView.The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann +11 more
wiley +1 more source
Estudo da atividade antiinflamatória dos ligantes do receptor periférico dos benzodiazepínicos: Pk11195 e Ro5-4864 [PDF]
, 2001 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências BiológicasO tratamento in vivo em camundongos com ligantes do receptor periférico benzodiazepínico (PBR) exerceram efeito inibitório na resposta inflamatória em dois ...
Torres, Sandra Regina Rachadel
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Advanced Science, EarlyView.We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li +9 more
wiley +1 more source
Advanced Science, EarlyView.HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li +8 more
wiley +1 more source
, 2010 This chapter provides the reader with practical information to be applied to the various remaining causes of macular edema. Some clinical cases of macular edema linked to ocular diseases like postradiotherapy for ocular melanomas remained of poor ...
Creuzot-Garcher, Catherine +1 more
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Clinical Ophthalmology, 2011 Hidetaka Noma1, Hideharu Funatsu1, Tatsuya Mimura2, Shuichiro Eguchi3, Katsunori Shimada41Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Yachiyo, Chiba, Japan; 2Department of Ophthalmology, University of ...
Hidetaka Noma +2 more
doaj
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source