Results 111 to 120 of about 277,895 (300)

Molecular analysis of mammalian adenylyl cyclases and edema factor, a bacterial adenylyly cyclase toxin [PDF]

, 2008
Adenylyl cyclases (ACs) catalyze the conversion of ATP to cAMP, an important second messenger central to many signaling pathways. Nine different isoforms of mammalian ACs (mACs) are present, each with distinct localization, physiological function and ...
Suryanarayana, Srividya
core  

Molecular Motions as a Drug Target: Mechanistic Simulations of Anthrax Toxin Edema Factor Function Led to the Discovery of Novel Allosteric Inhibitors

, 2012
Edema Factor (EF) is a component of <em>Bacillus anthracis</em> toxin essential for virulence. Its adenylyl cyclase activity is induced by complexation with the ubiquitous eukaryotic cellular protein, calmodulin (CaM).
Malliavin, Thérèse, Ladant, Daniel, Laine, Élodie, Daniel Ladant, Leandro Martínez, Arnaud Blondel, Blondel, Arnaud, Élodie Laine, Thérèse Malliavin, Martínez, Leandro   +9 more
core   +1 more source

Contributions of Edema Factor and Protective Antigen to the Induction of Protective Immunity by Bacillus anthracis Edema Toxin as an Intranasal Adjuvant [PDF]

, 2010
We have shown that intranasal coapplication of Bacillus anthracis protective Ag (PA) together with a B. anthracis edema factor (EF) mutant having reduced adenylate cyclase activity (i.e., EF-S414N) enhances anti-PA Ab responses, but also acts as a ...
Alexandra Duverger, Jeanne-Marie Carré, Carre, Jeanne-Marie, Junbae Jee, Wei-Jen Tang, Prosper N. Boyaka, Boyaka, Prosper, N., Leepla, Stephen, H., Stephen H. Leppla, Cormet-Boyaka, Estelle, Duverger, Alexandra, Estelle Cormet-Boyaka, Daniel Tomé, Jee, Junbae, Tang, Wei-Jen, Tomé, Daniel   +15 more
core   +1 more source

Use of antivascular endothelial growth factor for diabetic macular edema

Clinical Ophthalmology, 2010
Rushmia Karim, Benjamin TangUniversity of Sydney School of Public Health, Concord Repatriation General Hospital, Concord, NSW, AustraliaBackground: Diabetic macular edema (DME) is one of the manifestations of diabetic retinopathy leading to loss of ...
Rushmia Karim, Benjamin Tang
doaj  

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Activation of the Edema Factor of Bacillus anthracis by Calmodulin: Evidence of an Interplay between the EF-Calmodulin Interaction and Calcium Binding

, 2010
Calmodulin (CaM) is a remarkably flexible protein which can bind multiple targets in response to changes in intracellular calcium concentration. It contains four calcium-binding sites, arranged in two globular domains.
Malliavin, Thérèse, Malliavin, Thérèse E., Laine, Elodie, Leandro Martínez, Arnaud Blondel, Thérèse E. Malliavin, Elodie Laine, Blondel, Arnaud, Martínez, Leandro   +8 more
core   +1 more source

Analyzing In Silico the Relationship Between the Activation of the Edema Factor and Its Interaction With Calmodulin. [PDF]

Front Mol Biosci, 2020
Pitard I, Monet D, Goossens PL, Blondel A, Malliavin TE.   +4 more
europepmc   +1 more source

A Possible Factor in the Production and Distribution of Edema [PDF]

The Boston Medical and Surgical Journal, 1914
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openaire   +2 more sources

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source