Results 71 to 80 of about 1,790,156 (306)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
BMC Family Practice, 2018 Background The Chinese government offered various types of training programs for strengthening the role of doctors working in community health service institutions (CHSIs).
Shuang Shao +7 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Антибиотики и ХимиотерапияFavipiravir is an antiviral drug that has become widely used for the etiotropic treatment of COVID-19. According to a number of studies, the incidence of adverse reactions during favipiravir therapy reaches 93%, and the most common adverse reaction is an
Yu. V. Shevchuk +10 more
doaj +1 more source
Lessons from the future: ICT scenarios and the education of teachers [PDF]
, 2005 This paper reviews significant events of the last 25 years in schools and teacher education in England and looks ahead to the next 25 years. Various scenarios for the future are examined and the potential is considered for new forms of teachers' initial ...
Williams, Peter
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Instructing Judges: Ethical Experience and Educational Technique [PDF]
, 1995 Most professional responsibility textbooks do not discuss judicial conduct, and not surprisingly, many judges find themselves unprepared for the ethical dilemmas they face when they make the transition from partisan advocate to neutral arbiter.
Gray, Cynthia, Zemans, Frances Kahn
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
BMC Health Services Research, 2018 Background Migrants are the unique production of China’s urbanization process. They are often excluded from social welfare and security systems of cities, and often exposed to high health risk related closely to their health problems.
Shuang Shao +5 more
doaj +1 more source
High Marks for Lynch 7/29/2005 [PDF]
, 2005 Approval of the job John Lynch is doing as New Hampshire governor continues to rise. And despite continuing concerns over education funding, New Hampshire residents are increasingly optimistic that the state is on the right ...
Survey Center, UNH
core +1 more source