Results 71 to 80 of about 317,224 (312)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The needs of informal caregivers and barriers of primary care workers toward dementia management in primary care: a qualitative study in Beijing

BMC Family Practice, 2018
Background Informal caregivers of people with dementia in Beijing are increasingly called upon to provide home-based care for their patients due to the increasing number of dementia patients and the shortage of standardized institutional solutions of ...
Meirong Wang, Shuang Shao, Jing Li, Yingjie Liu, Xiaojingyuan Xu, Juan Du   +5 more
doaj   +1 more source

Continuing Education for Women, 1960-1975

, 1975
Source: University Archives Collection 1158, Information files,"Women's Continuing Education Program" 1970-79, Folder 2Continuing Education for Women. (1975). Continuing Education for Women, 1960-1975.
Continuing Education for Women
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

EXTRACORPOREAL RENAL SURGERY (LITERATURE REVIEW)

Сибирский онкологический журнал, 2017
Currently, along with the development of gravity blood surgery and transplantation, nephron-sparing surgery has become an established surgical treatment, particularly in situations in which preservation of renal parenchyma is critical.
R. I. Rasulov, V. V. Dvornichenko, A. A. Muratov   +2 more
doaj   +1 more source

Palestinian Continuing Education Under Occupation: Images of Distress and Possibilities for Hope

, 2010
This study examines how aspects of a militarily enforced occupation have influenced continuing education at Palestinian universities. It focuses on three influences: the impact of the politics of occupation on the history of continuing education ...
Davidson, Howard
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Development of ODL in a newly industrialised country according to face-to-face contact, ICT, and e-readiness

International Review of Research in Open and Distributed Learning, 2013
A large number of unqualified and under-qualified in-service teachers are holding back socio-economical development in South Africa, a newly industrialized country.
J Marinda van Zyl, Christoffel Johannes Els, A Seugnet Blignaut   +2 more
doaj   +1 more source

Demand for University Continuing Education in Canada: Who Participates and Why?

, 2009
The demand for and participation in continuing education by Canadian university graduates who completed bachelor and/or first professional degrees in 1995 are analyzed in this article.
Adamuti-Trache, Maria, Schuetze, Hans G.
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source