Results 81 to 90 of about 1,790,156 (306)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Association between social capital and utilization of essential public health services among elderly migrants: a multilevel logistic study based on the 2017 China migrant dynamic survey (CMDS)

BMC Public Health
Background As the number of elderly migrants in China continues to grow, it is necessary to pay closer attention to their health and health services. Some studies have confirmed that social capital plays a significant role in the utilization of health ...
Qi Luo, Xiaolei Chen, Linlin Zhao, Qinghua Hu, Juan Du, Shuang Shao   +5 more
doaj   +1 more source

New Research Provides Solutions to the Nursing Shortage: Improving Retention of Older and Experienced Nurses in the Workforce [PDF]

, 2008
Outlines research findings on how early retirement contributes to the shortage of nurses and on incentives that help retain experienced nurses, including financial support for continuing education and redesigned work spaces, hours, and benefit ...

core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Formación posgraduada en Ciencia-Tecnología-Sociedad en el sector de la salud. Resultados de una capacitación a profesores Postgraduate education on Science-Technology-Society in the health sector. Results of a training course for professors

Humanidades Médicas, 2010
A partir de una estrategia de educación continua se ejecutaron acciones para perfeccionar la educación en Ciencia-Tecnología-Sociedad en las universidades médicas cubanas.
María Elena Macías Llanes
doaj  

Factors affecting the essential medicine prescribing behavior among general practitioners in Beijing, China: a cross-sectional study with structural equation model

BMC Primary Care
Background The aim of this study is to explore the influence of GPs’information, motivation and behavior skills on EM prescribing behavior in urban and suburban districts.
Xiaolei Chen, Zhengwen Feng, Qi Luo, Hui Li, Shuang Shao, Juan Du   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Mandatory Continuing Education: Does It Really Protect Society from Incompetent Health Professionals [PDF]

, 1990
Although the focus is narrow, this article argues that, in the face of short half-lives of current knowledge, continuing education requirements are needed and suggests possible improvements in the way that continuing education is implemented.
McPartland, Patricia A.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The needs of informal caregivers and barriers of primary care workers toward dementia management in primary care: a qualitative study in Beijing

BMC Family Practice, 2018
Background Informal caregivers of people with dementia in Beijing are increasingly called upon to provide home-based care for their patients due to the increasing number of dementia patients and the shortage of standardized institutional solutions of ...
Meirong Wang, Shuang Shao, Jing Li, Yingjie Liu, Xiaojingyuan Xu, Juan Du   +5 more
doaj   +1 more source