Results 171 to 180 of about 3,832,732 (295)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Estimating the optimal number of samples to determine the effective population size in livestock. [PDF]

Front Genet
Manunza A, Cozzi P, Boettcher P, Curik I, Looft C, Colli L, Sölkner J, Mészáros G, Stella A.   +8 more
europepmc   +1 more source

PSMCanalysis of effective population sizes in molecular ecology and its application to black‐and‐whiteFicedulaflycatchers [PDF]

, 2016
Krystyna Nadachowska‐Brzyska, Reto Burri, Linnéa Smeds, Hans Ellegren   +3 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Estimating Recent and Historical Effective Population Size of Marine and Freshwater Sticklebacks. [PDF]

Mol Ecol
Feng X, Löytynoja A, Merilä J.
europepmc   +1 more source

Temporal variability in effective size (N _e) identifies sampling bias in close kin mark recapture estimate of population abundance (Nc(CKMR)) [PDF]

Daniel E. Ruzzante, Gregory R. McCracken, Dylan J. Fraser, John L. MacMillan, Colin F. Buhariwalla, Joanna Mills Flemming   +5 more
openalex   +1 more source

Recent human effective population size estimated from linkage disequilibrium [PDF]

, 2007
Albert Tenesa, Pau Navarro, Ben J. Hayes, David L. Duffy, Geraldine M Clarke, Michael E. Goddard, Peter M. Visscher   +6 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Multiple merger coalescent inference of effective population size. [PDF]

Philos Trans R Soc Lond B Biol Sci
Zhang J, Palacios JA.
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source