Results 101 to 110 of about 219,266 (297)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Location, location, location: the impact of migratory heterogeneity on T cell function

Frontiers in Immunology, 2013
T cell migration is crucial for an effective adaptive immune response to invading pathogens. Naive and memory T cells encounter pathogen antigens, become activated and differentiate into effector cells in secondary lymphoid tissues, and then migrate to ...
Bas J Baaten, Andrea M Cooper, Susan L Swain, Linda M Bradley   +3 more
doaj   +1 more source

Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells. [PDF]

PLoS ONE, 2010
Both CD28 and NKG2D can function as co-stimulatory receptors in human CD8+ T cells. However, their independent functional contributions in distinct CD8+ T cell subsets are not well understood.
Kamalakannan Rajasekaran, Va Xiong, Lee Fong, Jack Gorski, Subramaniam Malarkannan   +4 more
doaj   +1 more source

Generation of effector CD8⁺ T cells and their conversion to memory T cells [PDF]

Immunological Reviews, 2010
Summary:  Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector‐to‐memory transition, and mature into multipotent, functional memory T cells that self‐renew.
Weiguo, Cui, Susan M, Kaech
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling. [PDF]

PLoS Pathogens, 2015
The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in CD8+ T cell responses induced by SIVΔnef. As a novel approach to characterize
James M Billingsley, Premeela A Rajakumar, Michelle A Connole, Nadine C Salisch, Sama Adnan, Yury V Kuzmichev, Henoch S Hong, R Keith Reeves, Hyung-joo Kang, Wenjun Li, Qingsheng Li, Ashley T Haase, R Paul Johnson   +12 more
doaj   +1 more source

In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo [PDF]

, 2018
Indexación: Scopus.Memory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8+ T cell effector subsets to persist ...
Bono, M.R., Cruz, P., Cuadra, B., César Cárdenas, J., Fernández, D., Flores-Santibáñez, F., Gálvez-Cancino, F., Lladser, A., Núñez, S., Rosemblatt, M., Rosemblatt, M.V., Sauma, D.   +11 more
core   +2 more sources

T cell intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells [PDF]

The Journal of Immunology, 2018
Abstract Innate cytokines are critical drivers of priming and differentiation of naïve CD4 T cells but their role in memory T cell function is largely undefined. We discovered that while TCR and CD28 ligation are primary requirements for memory T cell reactivation, IL-1 acts as a licensing signal to permit effector cytokine production by
Aakanksha Jain, Ran Song, Edward K. Wakeland, Chandrashekhar Pasare   +3 more
openaire   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evaluation of IL-17 Producing Memory Regulatory and Effector T Cells Expressing CD26 Molecule in Patients with Psoriasis

Iranian Journal of Allergy, Asthma and Immunology, 2018
Memory regulatory T cells (Tregs) has been demonstrated to produce IL-17 in Psoriasis. Forkhead box P3 (Foxp3) has been demonstrated not to be reliable marker to evaluate Treg cells. Effector CD4+T cells also express Foxp3 after activation.
Behnaz Esmaeili, Parvin Mansouri, Alipasha Meysamie, Maryam Izad   +3 more
doaj   +1 more source