Results 11 to 20 of about 219,266 (297)

Transcriptional control of effector and memory CD8+ T cell differentiation [PDF]

Nature Reviews Immunology, 2012
During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool.
Susan M, Kaech, Weiguo, Cui
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Effector and memory T-cell differentiation: implications for vaccine development [PDF]

Nature Reviews Immunology, 2002
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this programme of development and the factors that might influence ...
Susan M, Kaech, E John, Wherry, Raft, Ahmed   +2 more
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Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation

Frontiers in Cell and Developmental Biology, 2021
CD8+ T cell effector and memory differentiation is tightly controlled at multiple levels including transcriptional, metabolic, and epigenetic regulation.
Qianqian Duan, Qianqian Duan, Jiying Ding, Jiying Ding, Jiying Ding, Fangfang Li, Fangfang Li, Fangfang Li, Xiaowei Liu, Xiaowei Liu, Yunan Zhao, Hongxiu Yu, Yong Liu, Yong Liu, Yong Liu, Lianjun Zhang, Lianjun Zhang, Lianjun Zhang   +17 more
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Lineage relationship of effector and memory T cells [PDF]

Current Opinion in Immunology, 2013
Adaptive immunity is characterized by the ability to form long-lived immunological memory. Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve T cells, providing better clearance of pathogens. Recent reviews have reinforced the text-book view that memory T cells arise from effector cells.
Nicholas P, Restifo, Luca, Gattinoni
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GOT1 regulates CD8+ effector and memory T cell generation

Cell Reports, 2023
T cell activation, proliferation, function, and differentiation are tightly linked to proper metabolic reprogramming and regulation. By using [U-13C]glucose tracing, we reveal a critical role for GOT1 in promoting CD8+ T cell effector differentiation and function.
Wei Xu, Chirag H. Patel, Liang Zhao, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Rachel S. Helms, Jiayu Wen, Jonathan D. Powell   +8 more
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Effector CD8 T cells dedifferentiate into long-lived memory cells [PDF]

Nature, 2017
Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an essential component of long-lived T cell immunity. These memory CD8 T cells remain poised to rapidly elaborate effector functions upon re-exposure to pathogens, but also have many properties in common with naive cells, including pluripotency and the ability to ...
Youngblood, Ben, Hale, J. Scott, Kissick, Haydn T., Ahn, Eunseon, Xu, Xiaojin, Wieland, Andreas, Araki, Koichi, West, Erin E., Ghoneim, Hazem E., Fan, Yiping, Dogra, Pranay, Davis, Carl W., Konieczny, Bogumila T., Antia, Rustom, Cheng, Xiaodong, Ahmed, Rafi   +15 more
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Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

Cell Reports, 2023
Summary: The differentiation of naive CD8+ T lymphocytes into cytotoxic effector and memory CTL results in large-scale changes in transcriptional and phenotypic profiles. Little is known about how large-scale changes in genome organization underpin these
Brendan E. Russ, Adele Barugahare, Pushkar Dakle, Kirril Tsyganov, Sara Quon, Bingfei Yu, Jasmine Li, Jason K.C. Lee, Moshe Olshansky, Zhaohren He, Paul F. Harrison, Michael See, Simone Nussing, Alison E. Morey, Vibha A. Udupa, Taylah J. Bennett, Axel Kallies, Cornelis Murre, Phillipe Collas, David Powell, Ananda W. Goldrath, Stephen J. Turner   +21 more
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Heterogeneity of the Memory CD4 T Cell Response: Persisting Effectors and Resting Memory T Cells [PDF]

The Journal of Immunology, 2001
AbstractDefining the cellular composition of the memory T cell pool has been complicated by an inability to distinguish effector and memory T cells. We present here an activation profile assay, using anti-CD3 and antigenic stimuli, that clearly distinguishes effector and memory CD4 T cells and defines subsets of long-lived memory CD4 T cells based on ...
M, Ahmadzadeh, S F, Hussain, D L, Farber
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Memory T Cells Discrepancies in COVID-19 Patients

Microorganisms, 2023
The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. The present study aimed to clarify the alterations in CD4+ and CD8+ memory T cells’ compartments in SARS-CoV-2-infected patients, with an ...
Hajir A. Al Saihati, Hosni A. M. Hussein, Ali A. Thabet, Ahmed A. Wardany, Sabry Y. Mahmoud, Eman S. Farrag, Taha I. A. Mohamed, Samah M. Fathy, Mohamed E. Elnosary, Ali Sobhy, Abdelazeem E. Ahmed, Ahmed M. El-Adly, Fareed S. El-Shenawy, Asmaa A. Elsadek, Amal Rayan, Zeinab Albadry M. Zahran, Omnia El-Badawy, Mohamed G. M. El-Naggar, Magdy M. Afifi, Asmaa M. Zahran   +19 more
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Dicer Regulates the Balance of Short-Lived Effector and Long-Lived Memory CD8 T Cell Lineages. [PDF]

PLoS ONE, 2016
MicroRNAs constitute a major post-transcriptional mechanism for controlling protein expression, and are emerging as key regulators during T cell development and function. Recent reports of augmented CD8 T cell activation and effector differentiation, and
Florian M Baumann, Yevgeniy Yuzefpolskiy, Surojit Sarkar, Vandana Kalia   +3 more
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