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T Cell Responses to Influenza Virus Infection: Effector and Memory Cells
Viral Immunology, 2004New approaches to visualizing antigen-specific primary responses to influenza and the development of memory subsets in distinct sites suggest that both CD4 and CD8 T cells play complex roles in primary viral clearance and have the potential to contribute to protection from secondary infection.
Susan L, Swain +2 more
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Early effector T helper cells are precursors to both terminal effectors and memory T cells (P1207)
The Journal of Immunology, 2013Abstract Effector memory CD4+ T cells (Tem) are important for protection from many chronic infections, but their development is poorly understood. While IFN-γ+ effector T cells (Teff) can survive into the memory phase in infection, it is not clear if mature Teff generate Tem, or if memory T cells diverge from Teff early after activation,
Michael Opata +4 more
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Distinct regulation of effector and memory T‐cell differentiation
Immunology & Cell Biology, 2008Three major subsets of antigen‐experienced T cells have been identified based on surface markers and distinct functional properties: short‐lived effector T cells, central memory T cells and effector memory T cells. The precise relationship among these subsets and their mode of differentiation are still controversial.
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Effector Memory CD8+ T Cells Are Resistant to Apoptosis
Annals of the New York Academy of Sciences, 2007Abstract: Based upon their migrating properties and effector functions, CD8+ T cells have been further classified into central memory (TCM) and two types of effector memory (TEM and TEMRA) cells. These memory cells display distinct replicative characteristics.
Sudhir, Gupta, Sastry, Gollapudi
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Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells
Science, 2000The immune response is initiated in organized lymphoid tissues where antigen-loaded dendritic cells (DCs) encounter antigen-specific T cells. DCs function as packets of information that must be decoded by the T cell before an appropriate immune response can be mounted.
A, Lanzavecchia, F, Sallusto
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Immunology
AbstractPsoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis
Guoshu Deng +10 more
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AbstractPsoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis
Guoshu Deng +10 more
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Intrinsic and extrinsic control of effector T cell survival and memory T cell development
Immunologic Research, 2008Following infection or vaccination T cells expand exponentially and differentiate into effector T cells in order to control infection and coordinate the multiple effector arms of the immune system. Soon after this expansion, the majority of antigen-specific T cells die to reattain homeostasis and a small pool of memory T cells forms to provide long ...
Timothy W, Hand, Susan M, Kaech
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Targeting effector memory T-cells with Kv1.3 blockers.
Current opinion in drug discovery & development, 2007After initially being pursued for general immunosuppression, the voltage-gated potassium channel Kv1.3 has more recently emerged as an attractive pharmacological target for the selective suppression of CCR7- effector memory T-cells in T-cell mediated autoimmune diseases such as multiple sclerosis, type 1 diabetes, rheumatoid arthritis and psoriasis ...
Heike, Wulff, Michael, Pennington
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Cytotoxic T Cell Effector and Memory Function in Viral Immunity
1996The first evidence that virus-specific CD8+ cytotoxic T lymphocytes (CTLs) are primary effectors in vivo came shortly after the discovery of major histo- compatibility complex (MHC)-restricted CD8+ CTL activity (Zinkernagel and Doherty 1974). Adoptive transfer of immune spleen cells from mice of MHC type A into A or (AxB) F1, but not B, virus-infected ...
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Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells
Immunological Reviews, 1993Zinkernagel, Rolf M. +5 more
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