Results 51 to 60 of about 219,266 (297)

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

Systemic hematogenous maintenance of memory inflation by MCMV infection. [PDF]

, 2014
Several low-grade persistent viral infections induce and sustain very large numbers of virus-specific effector T cells. This was first described as a response to cytomegalovirus (CMV), a herpesvirus that establishes a life-long persistent/latent ...
A Isa, A Koffron, A Krmpotic, A Lang, A Lang, A Warren, AC Thomas, AW Sylwester, B Bolinger, B Polic, C Pomeroy, C Söderberg-Nauclér, CC Brinkman, Chris A. Benedict, Christopher M. Snyder, CK Seckert, CK Seckert, CM Snyder, CM Snyder, CO Simon, Corinne J. Smith, D Masopust, D Pinschewer, DL Wallace, E Galkina, E Walter, EB Remmerswaal, EM van Leeuwen, EN Klyushnenkova, F Goodrum, FD Goodrum, G Xu, H Komatsu, H Turula, Holly Turula, J Mega, J Mercer, J Podlech, J Pollock, J Taylor-Wiedeman, J Zhang, K Hertoghs, K Kondo, K Kondo, KA Zurbach, KG Anderson, KG Anderson, KM Hsu, LA Farrington, LG Ledgerwood, M Hendrix, M Hendrix, M Hummel, M Kern, M Matloubian, M Reddehase, M Reeves, MA Jarvis, MA Jarvis, MW Munks, N Torti, NK Grzimek, O Norbeck, PA Swanson, PJ van de Berg, R Hendrix, R Holtappels, R Holtappels, R Holtappels, R Holtappels, R Simmons, R Simmons, S Hutchinson, S Riddell, S Sarkar, S Sierro, SG Hansen, SK Kurz, SK Kurz, SM Kaech, T Crough, TC Wirth, TI Arnon, U Karrer, YW Jung   +84 more
core   +4 more sources

MicroRNA miR-155 Affects Antiviral Effector and Effector Memory CD8 T Cell Differentiation [PDF]

Journal of Virology, 2013
ABSTRACT MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses.
Ching-Yi, Tsai, S Rameeza, Allie, Weijun, Zhang, Edward J, Usherwood   +3 more
openaire   +2 more sources

Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients.

PLoS ONE, 2013
The effector and regulatory T cell subpopulations involved in the development of acute rejection episodes in lung transplantation remain to be elucidated.
David San Segundo, María Ángeles Ballesteros, Sara Naranjo, Felipe Zurbano, Eduardo Miñambres, Marcos López-Hoyos   +5 more
doaj   +1 more source

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients. [PDF]

, 2012
Optimal vaccine strategies must be identified for improving T-cell vaccination against infectious and malignant diseases. MelQbG10 is a virus-like nano-particle loaded with A-type CpG-oligonucleotides (CpG-ODN) and coupled to peptide(16-35) derived from ...
Bachmann, M.F., Baumgaertner, P., Dummer, R., Geldhof, C., Goldinger, S.M., Hammann-Haenni, A., Kündig, T.M., Michielin, O., Mihic-Probst, D., Prior, J.O., Schwarz, K., Speiser, D.E., Willers, J.   +12 more
core   +2 more sources

Simultaneous coexpression of memory-related and effector-related genes by individual human CD8 T cells depends on antigen specificity and differentiation. [PDF]

, 2012
Phenotypic and functional cell properties are usually analyzed at the level of defined cell populations but not single cells. Yet, large differences between individual cells may have important functional consequences.
Baitsch, L., Gannon, P.O., Gupta, B., Iancu, E.M., Rufer, N., Speiser, D.E., Wieckowski, S.   +6 more
core   +1 more source

Autoimmune effector memory T cells: the bad and the good [PDF]

Immunologic Research, 2013
Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage.
Priyadharshini, Devarajan, Zhibin, Chen
openaire   +2 more sources

Stem, Effector, and Hybrid States of Memory CD8+ T Cells [PDF]

Trends in Immunology, 2020
CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and, consequently, the mechanism(s ...
Enrico, Lugli, Giovanni, Galletti, Shannon K, Boi, Benjamin A, Youngblood   +3 more
openaire   +2 more sources

Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment [PDF]

, 2014
Adenosine A2A receptor (A2AR) blockade enhances innate and adaptive immune responses. However, mouse genetic studies have shown that A2AR deletion does not inhibit the growth of all tumor types.
Cekic, C., Linden J.
core   +1 more source

Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function [PDF]

, 2009
Background Foxp3 has been suggested to be a standard marker for murine Tregs whereas its role as marker for human Tregs is controversial. While some reports have shown that human Foxp3+ T cells had no regulatory function others have shown their role in ...
Maciej Kmieciak, Madhu Gowda, Laura Graham, Kamar Godder, Harry D Bear, Francesco M Marincola, Masoud H Manjili   +6 more
core   +2 more sources