Results 11 to 20 of about 16,803 (230)
Efferocytosis during Skeletal Muscle Regeneration [PDF]
Cells, 2021 Efferocytosis, i.e., engulfment of dead cells by macrophages, is a crucial step during tissue repair after an injury. Efferocytosis delineates the transition from the pro-inflammatory phase of the inflammatory response to the recovery phase that ensures ...
Gaëtan Juban, Bénédicte Chazaud
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Efferocytosis in liver diseaseKey points
JHEP ReportsSummary: The process of dead cell clearance by phagocytic cells, called efferocytosis, prevents inflammatory cell necrosis and promotes resolution and repair. Defective efferocytosis contributes to the progression of numerous diseases in which cell death
Hongxue Shi +3 more
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Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages. [PDF]
FASEB JObesity disrupts macrophage adaptation to hypoxic microenvironments. In lean conditions, hypoxia induces H3K4me3‐dependent transcriptional programs that promote lactate accumulation, histone lactylation, and efficient efferocytosis. Diet‐induced obesity impairs this epigenetic–metabolic response, resulting in reduced lactate accumulation, defective ...
Takahashi K +14 more
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Current Biology, 2016 Kumar and Birge introduce efferocytosis - the process by which dead or dying cells are engulfed and digested by phagocytes.
Sushil, Kumar, Raymond B, Birge
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Cell Communication and Signaling, 2023 Background The inflammatory response induced by intestinal ischaemia‒reperfusion injury (I/R) is closely associated with infectious complications and mortality in critically ill patients, and the timely and effective clearance of apoptotic cells is an ...
Xiao-Hu Zhao +8 more
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Apoptosis recognition receptors regulate skin tissue repair in mice
eLife, 2023 Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition and clearance of apoptotic cells regulate repair are not fully understood. Here, we
Olivia Justynski +13 more
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Efferocytosis and Respiratory Disease
International Journal of Molecular Sciences, 2023 Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis.
Wenxue Zheng +9 more
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Efferocytosis and Lung Disease [PDF]
Chest, 2013 In healthy individuals, billions of cells die by apoptosis each day. Clearance of these apoptotic cells, termed "efferocytosis," must be efficient to prevent secondary necrosis and the release of proinflammatory cell contents that disrupt tissue homeostasis and potentially foster autoimmunity.
Alexandra L, McCubbrey +1 more
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Efferocytosis and autoimmune disease [PDF]
International Immunology, 2018 Abstract An enormous number of cells in the body die by apoptosis during development and under homeostasis. Apoptotic cells are swiftly engulfed by macrophages and digested into units. This removal of apoptotic cells is called ‘efferocytosis’.
Kawano, Mahiru, Nagata, Shigekazu
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
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