Results 31 to 40 of about 16,803 (230)
Intracellular HMGB1 Negatively Regulates Efferocytosis [PDF]
The Journal of Immunology, 2011 Abstract High mobility group box 1 (HMGB1) is a highly conserved protein with multiple intracellular and extracellular functions, including transcriptional regulation, as well as modulation of inflammation, cell migration, and ingestion of apoptotic cells.
Sami, Banerjee +5 more
openaire +2 more sources
Immunity, Inflammation and Disease, 2023 Efferocytosis can resolve airway inflammation and enhance airway tolerance in allergic asthma. While previous work has reported that progranulin (PGRN) regulated macrophage efferocytosis, but it is unclear whether PGRN‐mediated efferocytosis is ...
Qi Huang +9 more
doaj +1 more source
CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3 [PDF]
, 2018 CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer.
Amézaga, Núria +7 more
core +2 more sources
PAI-1 inhibits neutrophil efferocytosis [PDF]
Proceedings of the National Academy of Sciences, 2008 Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune responses and critical for the resolution of inflammation. Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including sepsis and acute lung injury,
Young-Jun, Park +7 more
openaire +2 more sources
Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung [PDF]
, 2013 Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a globally significant disease burden and frequently progresses to acute respiratory distress syndrome,
A Cross +58 more
core +1 more source
Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD [PDF]
, 2014 Our previous studies have shown that nutritional zinc restriction exacerbates airway inflammation accompanied by an increase in caspase-3 activation and an accumulation of apoptotic epithelial cells in the bronchioles of the mice.
Ackland,ML +12 more
core +2 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Eosinophil Apoptosis and Clearance in Asthma [PDF]
, 2013 Peer reviewedPublisher ...
Bickham U.R. +9 more
core +3 more sources
Internalization of apoptotic cells during efferocytosis requires Mertk-mediated calcium influx
Cell Death and Disease, 2023 Phagocytosis of apoptotic cells, called efferocytosis, requires calcium inside and outside of phagocytes. Due to its necessity, calcium flux is sophisticatedly modulated, and the level of intracellular calcium in phagocytes is ultimately elevated during ...
Susumin Yang +8 more
doaj +1 more source
Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
Frontiers in Cardiovascular Medicine, 2018 Efficient clearance of apoptotic cells, termed efferocytosis, critically regulates normal homeostasis whereas defective uptake of apoptotic cells results in chronic and non-resolving inflammatory diseases, such as advanced atherosclerosis.
Arif Yurdagul +12 more
doaj +1 more source