Results 81 to 90 of about 122,546 (256)

An efflux pump in genomic island GI-M202a mediates the transfer of polymyxin B resistance in Pandoraea pnomenusa M202 [PDF]

, 2023
Wenhui Gao, Congcong Li, Fengtian Wang, Yilin Yang, Lu Zhang, Zhongxue Wang, Xi Chen, Meixia Tan, Guangxiang Cao, Gongli Zong   +9 more
openalex   +1 more source

Investigation of the role of Cremophor RH 40 and Cremophor EL in the inhibition of efflux pump of Pseudomonas aeruginosa

Heliyon
Background: There is increasing emphasis on restoring the efficacy of existing antibiotics instead of developing new ones. Objectives: This study aimed to determine the role of Cremophor EL and Cremophor RH40 in the inhibition of efflux pumps in MDR ...
Muhammad Asim, Yasin Ahmad, Momin Khan, Zeeshan Ahmad, Awais Khalid, Pervaiz Ahmad, Abdulhameed Khan, Fakhrul Ahsan, Mohsin Kazi, Samer H. Zyoud   +9 more
doaj   +1 more source

Escherichia coli EHEC Germany outbreak preliminary functional annotation using BG7 system [PDF]

, 2011
We have annotated the European outbreak E. coli EHEC genome sequenced by BGI (6-2-2011) and assembled with MIRA by Nick Loman (6-2-2011 ). Our system BG7, Bacterial Genome annotation of Era7 Bioinformatics, predicts ORFs and annotates them based on ...
Eduardo Pareja, Eduardo Pareja-Tobes, Marina Manrique, Pablo Pareja-Tobes, Raquel Tobes   +4 more
core   +2 more sources

Microbial Efflux Pump Inhibition: Tactics and Strategies [PDF]

Current Pharmaceutical Design, 2011
Traditional antimicrobials are increasingly suffering from the emergence of multidrug resistance among pathogenic microorganisms. To overcome these deficiencies, a range of novel approaches to control microbial infections are under investigation as potential alternative treatments. Multidrug efflux is a key target of these efforts.
George P, Tegos, Mark, Haynes, J Jacob, Strouse, Mohiuddin Md T, Khan, Cristian G, Bologa, Tudor I, Oprea, Larry A, Sklar   +6 more
openaire   +2 more sources

Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]

, 2010
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core   +2 more sources

Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions [PDF]

, 2016
The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents.

core   +2 more sources

Clinically Approved Drugs Inhibit the Staphylococcus aureus Multidrug NorA Efflux Pump and Reduce Biofilm Formation

Frontiers in Microbiology, 2019
Staphylococcus aureus has acquired resistance to antibiotics since their first use. The S. aureus protein NorA, an efflux pump belonging to the major facilitator superfamily (MFS), contributes to resistance to fluoroquinolones (e.g., ciprofloxacin ...
Saskia Zimmermann, Saskia Zimmermann, Mareike Klinger-Strobel, Jürgen A. Bohnert, Jürgen A. Bohnert, Sindy Wendler, Jürgen Rödel, Mathias W. Pletz, Bettina Löffler, Bettina Löffler, Lorena Tuchscherr, Lorena Tuchscherr   +11 more
doaj   +1 more source

CmeABC multidrug efflux pump contributes to antibiotic resistance and promotes 'Campylobacter jejuni' survival and multiplication in 'Acanthamoeba polyphaga' [PDF]

, 2017
Campylobacter jejuni is a foodborne pathogen recognized as the leading cause of human bacterial gastroenteritis. The wide use of antibiotics in medicine and in animal husbandry has led to an increased incidence of antibiotic resistance in Campylobacter ...
Alan M. Seddon, Alvarez-Ortega, Amritha Ramesh, Ana Vieira, Anacarso, Andrew J. McBain, Andrey V. Karlyshev, Axelsson-Olsson, Axelsson-Olsson, Axelsson-Olsson, Backert, Bacon, Baldvinsson, Bare, Bare, Barker, Baugh, Blanco, Bolton, Bronowski, Buckley, Bui, Bui, Cagliero, Chu, Cirillo, Dasti, Dirks, Drevets, Elsinghorst, Fernando, Goni, Gregson, Griekspoor, Hirakata, Hofreuter, Iovine, Johnson, Joshua, Karlyshev, Karlyshev, Lambrecht, Lehri, Lin, Lin, Lugert, Mavri, Olofsson, Olsson, Padilla, Piddock, Poole, Sandstrom, Siddiqui, Siddiqui, Siddiqui, Sifre, Snelling, Snelling, Stintzi, Sun, Thomas, Tosetti, Vaerewijck, Vieira, Webber, Wijdicks, Winiecka-Krusnell, Yao, Young   +69 more
core   +1 more source

Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to Acinetobacter baumannii

Pathogens
Bacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells.
Kira M. Zack, Trent Sorenson, Suresh G. Joshi   +2 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources