Results 1 to 10 of about 59,132 (312)

A novel role for colistin as an efflux pump inhibitor in multidrug-resistant Klebsiella pneumoniae [PDF]

Scientific Reports
Antimicrobial resistance (AMR) is a global challenge that demands new strategies to maintain the effectiveness of current treatments. AMR arises through various mechanisms, including overexpression of drug efflux pumps. The AcrAB-TolC efflux pump is used
Rajnikant Sharma, Shekhar Yeshwante, Ngoc Minh Bui, Vincenzo Carbone, Leslie Hicks, Bruce E. Blough, Tony Velkov, Gauri G. Rao   +7 more
doaj   +2 more sources

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria [PDF]

Molecules, 2017
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials.
Gabriella Spengler, Annamária Kincses, Márió Gajdács, Leonard Amaral   +3 more
doaj   +4 more sources

Overexpression of the adeB Efflux Pump Gene in Tigecycline-Resistant Acinetobacter baumannii Clinical Isolates and Its Inhibition by (+)Usnic Acid as an Adjuvant

Antibiotics, 2021
Acinetobacter species are among the most life-threatening Gram-negative bacilli, causing hospital-acquired infections, and they are associated with high morbidity and mortality. They show multidrug resistance that acts via various mechanisms.
Nagaraju Bankan, Fathimunnisa Koka, Rajagopalan Vijayaraghavan, Sreekanth Reddy Basireddy, Selvaraj Jayaraman   +4 more
doaj   +1 more source

Antibiotic resistance assessment and multi-drug efflux pumps of Enterococcus faecium isolated from clinical specimens

Journal of Infection in Developing Countries, 2023
Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii, Masoud Alebouyeh, Mohammad Bagher Sohrabi, Parisa Eslami, Mojgan Fazli, Maryam Ebrahimi, Parinaz HajiAsgarli, Marjan Rashidan   +7 more
doaj   +1 more source

Detection of Efflux Pump Using Ethidium Bromide-Agar Cartwheel Method in Acinetobacter baumannii Clinical Isolates

Journal of Medical Microbiology and Infectious Diseases, 2022
Introduction: In the past decade, multidrug-resistant Acinetobacter baumannii has become one of the most critical challenges in treating infected patients. The AdeABC efflux pump is the most important among the various resistance mechanisms. This pump
Amin Sepehr1, Sepideh Fereshteh1, Nader Shahrokhi2   +2 more
doaj   +1 more source

AcrAB-TolC Efflux Pump Mediated Resistance to Carbapenems among Clinical Isolates of Enterobacteriaceae

Journal of Pure and Applied Microbiology, 2022
AcrAB-TolC is a resistance nodulation division type of efflux pump present in Enterobacteriaceae. It non-specifically effluxes antibiotics out of the bacterial cell, thus conferring drug resistance.
Priyadharshini Sekar, Dhruv Mamtora, Pallavi Bhalekar, Padma Krishnan   +3 more
doaj   +1 more source

Possible Role of Curcumin as an Efflux Pump Inhibitor in Multi Drug Resistant Clinical Isolates of Pseudomonas aeruginosa [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: Multidrug resistant non-fermenters are continuously increasing in hospital and ICU settings. One of the mechanisms of developing drug resistance is possession of efflux pump through which bacteria extrude antimicrobial agents and other ...
Nidhi Negi, Pradyot Prakash, Mohan Lal Gupta, Tribhuban Mohan Mohapatra   +3 more
doaj   +1 more source

The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii

Antibiotics, 2023
Multidrug resistant (MDR) Acinetobacter baumannii is a critical opportunistic pathogen in healthcare-associated infections (HAI). This is attributed to several factors, including its ability to develop biofilms that can enhance antimicrobial resistance ...
Ola A. Abd El-Rahman, Fatma Rasslan, Safaa S. Hassan, Hossam M. Ashour, Reham Wasfi   +4 more
doaj   +1 more source

Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]

, 2017
Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio, Bondã¬, Roslen, Imperi, Francesco, Leoni, Livia, Longo, Francesca, Messina, Marco, Pillai, Cejoice Ramachandran, Rampioni, Giordano, Visca, Paolo   +8 more
core   +2 more sources

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources