Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India. [PDF]
PLoS ONE, 2016 OBJECTIVES:The present study was undertaken to investigate the mutations that are present in mexR gene of multidrug resistant (MDR) isolates of Pseudomonas aeruginosa collected from a tertiary referral hospital of north east India.
Debarati Choudhury +8 more
doaj +1 more source
Transcriptome assembly and profiling of Candida auris reveals novel insights into biofilm-mediated resistance [PDF]
, 2018 Candida auris has emerged as a significant global nosocomial pathogen. This is primarily due to its antifungal resistance profile but also its capacity to form adherent biofilm communities on a range of clinically important substrates.
Ben-Ami +63 more
core +4 more sources
Identification and evolution of drug efflux pump in clinical Enterobacter aerogenes strains isolated in 1995 and 2003. [PDF]
PLoS ONE, 2008 BackgroundThe high mortality impact of infectious diseases will increase due to accelerated evolution of antibiotic resistance in important human pathogens.
Jacqueline Chevalier +5 more
doaj +1 more source
Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]
, 2017 Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef +7 more
core +3 more sources
Iranian Journal of Public Health, 2020 Background: The AcrB efflux pump in Salmonella species plays a significant role in the development of antibiotic resistance in ciprofloxacin-resistant Salmonella enteritidis.
Marjan KHOSRAVANI +2 more
doaj +1 more source
Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]
, 2018 The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan +5 more
core +1 more source
Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance. [PDF]
PLoS ONE, 2015 To identify a novel class of inhibitors of fungal transporters involved in drug resistance.A series of structurally-related low molecular mass compounds was synthesized using combinatorial chemistry of a cyclobutene-dione (squarile) core. These compounds
Mikhail V Keniya +4 more
doaj +1 more source
The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors
Journal of Global Antimicrobial Resistance, 2021 Efflux pumps are transmembrane proteins associated with bacterial resistance mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular medium, preventing the pharmacological action of these drugs. This study aimed to evaluate in vitro the antibacterial activity of 1,8-naphthyridines sulfonamides, as well as their ...
Cícera Datiane de Morais Oliveira-Tintino +18 more
openaire +3 more sources
First emergence of acrAB and oqxAB mediated tigecycline resistance in clinical isolates of Klebsiella pneumoniae pre-dating the use of tigecycline in a Chinese hospital. [PDF]
PLoS ONE, 2014 Tigecycline is one of the few therapeutic options for treating infections caused by some multi-drug resistant pathogens, such as Klebsiella pneumoniae. However, tigecycline-resistant K. pneumoniae has been discovered recently in China. From 2009 to 2013,
Xue Zhong +5 more
doaj +1 more source
Pseudomonas aeruginosa mexR and mexEF Antibiotic Efflux Pump Variants Exhibit Increased Virulence
Antibiotics, 2021 Antibiotic-resistant Pseudomonas aeruginosa infections are the primary cause of mortality in people with cystic fibrosis (CF). Yet, it has only recently become appreciated that resistance mutations can also increase P.
Mylene Vaillancourt +4 more
doaj +1 more source