Results 81 to 90 of about 59,132 (312)
Microbiology, 2023 The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level. The treatment options against infections caused by multiple drug-resistant bacteria are shrinking gradually. The current pace of the discovery of new antibacterial entities is lagging behind the rate of development of new resistance.
Amit Gaurav +4 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales +11 more
wiley +1 more source
Drugs and Drug Candidates, 2023 The high frequency of infectious diseases has spurred research into effective tactics to combat microorganisms that are resistant to several drugs.
Samara Barbosa de Brito +13 more
doaj +1 more source
Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor [PDF]
, 2007 Polarized epithelial non-human (canine) cell lines stably transfected with human or murine complementary DNA (cDNA) encoding for various efflux transporters (P-gp/MDR1, MRP1, MRP2, and Bcrp1) were used to study transepithelial transport of Lopinavir (LVR)
Agarwal, Sheetal +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu +10 more
wiley +1 more source
PLoS ONE, 2020 The aim of this study was to determine the activity and synergistic mechanisms of resveratrol in combination with chlorhexidine against carbapenem-resistant Acinetobacter baumannii clinical isolates.
Uthaibhorn Singkham-In +4 more
doaj +1 more source
Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. [PDF]
PLoS ONE, 2011 BACKGROUND:Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative ...
Yiannis C Fiamegos +8 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.The study presents an antibiotic‐free strategy using medical fabrics coated with supramolecular assemblies of polyarginine and hyaluronic acid. These coatings showed strong antimicrobial and anti‐biofilm activity in vitro and in vivo, achieving major bacterial load reductions, including against MRSA.
Adjara Diarrassouba +18 more
wiley +1 more source
Tigecycline efflux as a mechanism for nonsusceptibility in acinetobacter baumannii [PDF]
, 2007 Tigecycline has an extended spectrum of in vitro antimicrobial activities, including that against multidrug-resistant Acinetobacter. After identifying bloodstream isolates of Acinetobacter with reduced susceptibilities to tigecycline, we performed a ...
Peleg, Anton Y. +2 more
core +1 more source
Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors [PDF]
Molecules, 2019 Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated.
Tímea Mosolygó +10 more
openaire +8 more sources